All Phenotypes Krt14<tm1.1(cre)Wbm> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Bmpr1a^tm2.1Bhr/Bmpr1a^tm2.1Bhr Krt14^{tm1.1(cre)Wbm}/Krt14⁺	involves: 129P2/OlaHsd * 129S7/SvEvBrd	MGI:5508225
cn2	Bmpr1a^tm2.1Bhr/Bmpr1a^tm2.1Bhr Ctnnb1^tm1Mmt/Ctnnb1⁺ Krt14^{tm1.1(cre)Wbm}/Krt14⁺	involves: 129P2/OlaHsd * 129S7/SvEvBrd * 129X1/SvJ	MGI:5508218
cn3	Ctnnb1^tm1Mmt/Ctnnb1⁺ Krt14^{tm1.1(cre)Wbm}/Krt14⁺	involves: 129P2/OlaHsd * 129X1/SvJ	MGI:5508224
cn4	Ctnnb1^tm4Wbm/Ctnnb1^tm4Wbm Krt14^{tm1.1(cre)Wbm}/Krt14⁺	involves: 129P2/OlaHsd * C57BL/6	MGI:2673250
cn5	Krt14^{tm1.1(cre)Wbm}/Krt14⁺ Tg(KRT14-Snai1)1Efu/0 Trp53^tm1Brn/Trp53^tm1Brn	involves: 129P2/OlaHsd * CD-1	MGI:6196149

Allelic Composition	Bmpr1a^tm2.1Bhr/Bmpr1a^tm2.1Bhr Krt14^{tm1.1(cre)Wbm}/Krt14⁺
Genetic Background	involves: 129P2/OlaHsd * 129S7/SvEvBrd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmpr1a^tm2.1Bhr mutation (1 available); any Bmpr1a mutation (90 available)
Krt14^{tm1.1(cre)Wbm} mutation (1 available); any Krt14 mutation (38 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

neoplasm ( J:199091 )

N	• mice do not develop salivary gland squamous cell carcinoma

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

decreased tumor-free survival time ( J:199091 )

• mutants succumb to tumors rapidly, dying between P75 and P90

neoplasm

increased salivary gland tumor incidence ( J:199091 )

• rapidly develop aggressive tumors in the salivary glands

• tumors contain transplantable and hyperproliferative tumor propagating cells (CD24+CD29+)

• treatment of cultured CD24+CD29+ tumor cells with the canonical Wnt inhibitor ICG-001 blocks proliferation of these cells

• CD24+CD29+ tumor propagating cells from salivary gland tumors exhibit unrestricted self-renewal in salisphere culture

increased squamous cell carcinoma incidence ( J:199091 )

• tumors arise from the submandibular salivary glands and are classified as salivary gland squamous cell carcinoma

digestive/alimentary system

increased salivary gland tumor incidence ( J:199091 )

• rapidly develop aggressive tumors in the salivary glands

• tumors contain transplantable and hyperproliferative tumor propagating cells (CD24+CD29+)

• treatment of cultured CD24+CD29+ tumor cells with the canonical Wnt inhibitor ICG-001 blocks proliferation of these cells

• CD24+CD29+ tumor propagating cells from salivary gland tumors exhibit unrestricted self-renewal in salisphere culture

endocrine/exocrine glands

increased salivary gland tumor incidence ( J:199091 )

• rapidly develop aggressive tumors in the salivary glands

• tumors contain transplantable and hyperproliferative tumor propagating cells (CD24+CD29+)

• treatment of cultured CD24+CD29+ tumor cells with the canonical Wnt inhibitor ICG-001 blocks proliferation of these cells

• CD24+CD29+ tumor propagating cells from salivary gland tumors exhibit unrestricted self-renewal in salisphere culture

integument

increased hair follicle number ( J:199091 )

• excessive supernumerary hair follicles in the skin

craniofacial

increased salivary gland tumor incidence ( J:199091 )

• rapidly develop aggressive tumors in the salivary glands

• tumors contain transplantable and hyperproliferative tumor propagating cells (CD24+CD29+)

• treatment of cultured CD24+CD29+ tumor cells with the canonical Wnt inhibitor ICG-001 blocks proliferation of these cells

• CD24+CD29+ tumor propagating cells from salivary gland tumors exhibit unrestricted self-renewal in salisphere culture

growth/size/body

increased salivary gland tumor incidence ( J:199091 )

• rapidly develop aggressive tumors in the salivary glands

• tumors contain transplantable and hyperproliferative tumor propagating cells (CD24+CD29+)

• treatment of cultured CD24+CD29+ tumor cells with the canonical Wnt inhibitor ICG-001 blocks proliferation of these cells

• CD24+CD29+ tumor propagating cells from salivary gland tumors exhibit unrestricted self-renewal in salisphere culture

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
salivary gland carcinoma		DOID:0050904		J:199091

Allelic Composition	Ctnnb1^tm1Mmt/Ctnnb1⁺ Krt14^{tm1.1(cre)Wbm}/Krt14⁺
Genetic Background	involves: 129P2/OlaHsd * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1^tm1Mmt mutation (0 available); any Ctnnb1 mutation (49 available)
Krt14^{tm1.1(cre)Wbm} mutation (1 available); any Krt14 mutation (38 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

neoplasm ( J:199091 )

N	• mice do not develop salivary squamous cell carcinoma

Allelic Composition	Ctnnb1^tm4Wbm/Ctnnb1^tm4Wbm Krt14^{tm1.1(cre)Wbm}/Krt14⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1^tm4Wbm mutation (1 available); any Ctnnb1 mutation (49 available)
Krt14^{tm1.1(cre)Wbm} mutation (1 available); any Krt14 mutation (38 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

integument

abnormal hair growth ( J:69463 )

alopecia ( J:69463 )

• reduced number of zigzag hairs

• hair loss around 4 weeks of age and no regrowth

• initial phase hair growth occurs until 16 days of age

• no hairless skin patches at 8 days of age

• hair shafts become separated from dermal papillae

Allelic Composition	Krt14^{tm1.1(cre)Wbm}/Krt14⁺ Tg(KRT14-Snai1)1Efu/0 Trp53^tm1Brn/Trp53^tm1Brn
Genetic Background	involves: 129P2/OlaHsd * CD-1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Krt14^{tm1.1(cre)Wbm} mutation (1 available); any Krt14 mutation (38 available)
Tg(KRT14-Snai1)1Efu mutation (0 available)
Trp53^tm1Brn mutation (18 available); any Trp53 mutation (240 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

increased sebaceous gland tumor incidence ( J:229072 )

• sebaceous gland carcinoma

integument

increased sebaceous gland tumor incidence ( J:229072 )

• sebaceous gland carcinoma

increased skin tumor incidence ( J:229072 )

• mice develop skin tumors more rapidly than single Tg(KRT14-Snai1)1Efu expressing mice, with a median latency of 176 days

• however, mice do not develop more tumors than Tg(KRT14-Snai1)1Efu mice alone

• tumors include basal cell carcinoma, squamous cell carcinoma, and sebaceous gland carcinoma and more aggressive carcinosarcomas characterized by the biphasic appearance of intermixed epithelial and mesenchymal elements

increased basal cell carcinoma incidence ( J:229072 )

increased skin squamous cell carcinoma incidence ( J:229072 )

neoplasm

increased sebaceous gland tumor incidence ( J:229072 )

• sebaceous gland carcinoma

increased skin tumor incidence ( J:229072 )

• mice develop skin tumors more rapidly than single Tg(KRT14-Snai1)1Efu expressing mice, with a median latency of 176 days

• however, mice do not develop more tumors than Tg(KRT14-Snai1)1Efu mice alone

increased basal cell carcinoma incidence ( J:229072 )

increased skin squamous cell carcinoma incidence ( J:229072 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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