Phenotypes associated with this allele

• Allele Symbol: Galk1^tm1Stb
• Allele Name: targeted mutation 1, Dwight Stambolian
• Allele ID: MGI:2148688
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Galk1^tm1Stb/Galk1^tm1Stb	involves: 129S6/SvEvTac	MGI:3758740
cx2	Galk1^tm1Stb/Galk1^tm1Stb Tg(Cryaa-AKR1B1)222Smch/0	involves: 129S6/SvEvTac * C57BL * CBA	MGI:3784035
cx3	Galk1^tm1Stb/Galk1^tm1Stb Tg(Cryaa-AKR1B1)648Smch/0	involves: 129S6/SvEvTac * C57BL * CBA	MGI:3784037

Genotype
MGI:3758740

hm1

• Allelic Composition: Galk1^tm1Stb/Galk1^tm1Stb
• Genetic Background: involves: 129S6/SvEvTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

vision/eye phenotype ( J:63743 )

N • on a 40% galactose or 40% glucose diet, mice do not develop cataracts

homeostasis/metabolism

abnormal homeostasis ( J:63743 )

• on a 40% glucose diet, mice exhibit detectable accumulation of galactose and galactitol in liver, brain, and kidney in contrast to wild-type animals

• on a 40% galactose diet, markedly elevated galactitol levels are observed in liver and kidney in mutants and wild-type, but levels are higher in mutants

Genotype
MGI:3784035

cx2

• Allelic Composition: Galk1^tm1Stb/Galk1^tm1Stb; Tg(Cryaa-AKR1B1)222Smch/0
• Genetic Background: involves: 129S6/SvEvTac * C57BL * CBA

vision/eye

cataract ( J:63743 )

• mice develop cataracts in absence of high galactose diet; cataract formation is detected at P0 on nomral or 40% glucose diet

• cataracts are detected as vacuoles at the periphery of the lens

homeostasis/metabolism

abnormal homeostasis ( J:63743 )

• at P0, lenses have high levels of galactitol relative to controls

Genotype
MGI:3784037

cx3

• Allelic Composition: Galk1^tm1Stb/Galk1^tm1Stb; Tg(Cryaa-AKR1B1)648Smch/0
• Genetic Background: involves: 129S6/SvEvTac * C57BL * CBA

vision/eye

cataract ( J:63743 )

• mice develop cataracts in absence of high galactose diet; cataract formation is detected at P0 on nomral or 40% glucose diet

• cataracts are detected as vacuoles at the periphery of the lens

homeostasis/metabolism

abnormal homeostasis ( J:63743 )

• at P0, lenses have high levels of galactitol relative to controls