Phenotypes associated with this allele

• Allele Symbol: Pon1^tm1Lus
• Allele Name: targeted mutation 1, Aldons J Lusis
• Allele ID: MGI:2148702
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pon1^tm1Lus/Pon1^tm1Lus	involves: 129X1/SvJ * C57BL/6J	MGI:2654937
cx2	Apoe^tm1Unc/Apoe^tm1Unc Pon1^tm1Lus/Pon1^tm1Lus	involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6J	MGI:2654938

Genotype
MGI:2654937

hm1

• Allelic Composition: Pon1^tm1Lus/Pon1^tm1Lus
• Genetic Background: involves: 129X1/SvJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

oxidative stress ( J:82696 )

• increased oxidative stress in serum and peritoneal and arterial macrophages

• 48% increase in lipid peroxides content in peritoneal macrophages, decrease in glutathione content, and 40% increase in capacity of peritoneal macrophagaes to oxidize LDL

cardiovascular system

increased susceptibility to atherosclerosis ( J:63392 )

• on a high-fat, high-cholesterol diet, mutants are more susceptible to atherosclerosis than wild-type

homeostasis/metabolism

increased circulating LDL cholesterol level ( J:63392 )

• females, but not males, have a moderate increase in LDL levels

increased circulating VLDL cholesterol level ( J:63392 )

• females, but not males, have a moderate increase in VLDL levels

abnormal enzyme/coenzyme activity ( J:63392 )

• ~85% decrease in plasma arylesterase activity using phenylacetate as substrate

increased physiological sensitivity to xenobiotic ( J:63392 )

• mutants are extremely sensitive to the toxic effects of chlorpyrifos, an organophosphate insecticide, and chlorpyrifos oxon

Genotype
MGI:2654938

cx2

• Allelic Composition: Apoe^tm1Unc/Apoe^tm1Unc; Pon1^tm1Lus/Pon1^tm1Lus
• Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6J

cardiovascular system

atherosclerotic lesions ( J:82696 )

• 42% increase in atherosclerotic lesion area on a chow diet compared to single Apoe homozygotes at 4 months of age

cellular

oxidative stress ( J:82696 )

• increased oxidative stress in serum and peritoneal and arterial macrophages

• 71% increase increase in peroxides content in arterial macrophages and 80% increase in peritoneal macrophages, decrease in glutathione content, and 19% decrease in the capacity of peritoneal macrophages to oxidize LDL