Phenotypes associated with this allele

• Allele Symbol: Calca^tm1Jpc
• Allele Name: targeted mutation 1, Jean-Pierre Changeux
• Allele ID: MGI:2148771
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Calca^tm1Jpc/Calca^tm1Jpc	involves: 129P2/OlaHsd	MGI:3851005
hm2	Calca^tm1Jpc/Calca^tm1Jpc	involves: 129P2/OlaHsd * C57BL/6	MGI:3851001

Genotype
MGI:3851005

hm1

• Allelic Composition: Calca^tm1Jpc/Calca^tm1Jpc
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

enhanced behavioral response to nicotine ( J:68693 )

• the analgesic effect of nicotine is amplified in these mice, as assayed by a tail flick response

decreased behavioral withdrawal response ( J:68693 )

• while mutant mice have the same predilection to heroin addiction, mice display much fewer withdrawal signs, such as jumping, after drug removal

increased chemical nociceptive threshold ( J:68693 )

• a significant attenuation of hind paw licking response is observed after capsaicin injection

• mice also show reduced hind paw licking during the early (acute) phase of the formalin exposure and the second (tonic) phase

• mice also showed less edema swelling to carrageenan injections and less intestinal cramping from acetic acid injections

abnormal chemically-elicited antinociception ( J:68693 )

• morphine elicited antinociception is reduced in this mutant mice

• nicotine elicited antinociception is increased in these mice

Genotype
MGI:3851001

hm2

• Allelic Composition: Calca^tm1Jpc/Calca^tm1Jpc
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

behavior/neurological

impaired behavioral response to xenobiotic ( J:54422 )

• morphine elicited antinociception is reduced in this mutant mice

• tail flick latency response begins to decrease compared to controls 30-40 minutes after injection

• maximum difference is 60% less effectiveness at 1-2 hours after injection