Phenotypes associated with this allele

• Allele Symbol: Insl3^tm1Par
• Allele Name: targeted mutation 1, Luis F Parada
• Allele ID: MGI:2148889
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Insl3^tm1Par/Insl3^tm1Par	involves: 129/Sv * CD-1	MGI:2661963
ht2	Insl3^tm1Par/Insl3^+	involves: 129/Sv * CD-1	MGI:2661992

Genotype
MGI:2661963

hm1

• Allelic Composition: Insl3^tm1Par/Insl3^tm1Par
• Genetic Background: involves: 129/Sv * CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal spermatid morphology ( J:55881 )

♂ • absent

multinucleated giant male germ cells ( J:55881 )

♂

reproductive system

multinucleated giant male germ cells ( J:55881 )

♂

abnormal spermatogenesis ( J:55881 )

♂ • absence of spermatids and mature sperm

abnormal spermatid morphology ( J:55881 )

♂ • absent

abnormal gubernaculum morphology ( J:55881 )

• males exhibit thin gubernacular bulbs and cords which collectively resemble the wild-type female gubernaculum

abnormal male reproductive system morphology ( J:55881 )

♂

small testis ( J:55881 )

♂ • testes were of normal size at birth but progressively degenerated

♂ • however, prostate gland morphology, seminal gland morphology, and serum testosterone levels are normal

bilateral cryptorchism ( J:55881 )

♂ • bilateral cryptorchism with testes resting adjacent to the lower pole of the kidneys

♂ • the right testicle of some males was in the contralateral position

abnormal vas deferens morphology ( J:55881 )

♂ • vas deferens were elongated

prolonged estrous cycle ( J:55881 )

♀ • prolonged cycle with each phase extended

♀ • most females had cycles exceeding 20 days

female infertility ( J:55881 )

♀ • 22% of females were infertile, however ovarian and uterine morphology was normal

♀ • fertile females gave birth to fewer litters

♀ • litters were of normal size

male infertility ( J:55881 )

♂

behavior/neurological

behavior/neurological phenotype ( J:55881 )

N • normal mounting and copulatory behavior

endocrine/exocrine glands

small testis ( J:55881 )

♂ • testes were of normal size at birth but progressively degenerated

♂ • however, prostate gland morphology, seminal gland morphology, and serum testosterone levels are normal

bilateral cryptorchism ( J:55881 )

♂ • bilateral cryptorchism with testes resting adjacent to the lower pole of the kidneys

♂ • the right testicle of some males was in the contralateral position

skeleton

abnormal gubernaculum morphology ( J:55881 )

• males exhibit thin gubernacular bulbs and cords which collectively resemble the wild-type female gubernaculum

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
cryptorchidism		DOID:11383	OMIM:219050	J:55881

Genotype
MGI:2661992

ht2

• Allelic Composition: Insl3^tm1Par/Insl3⁺
• Genetic Background: involves: 129/Sv * CD-1

endocrine/exocrine glands

cryptorchism ( J:55881 )

♂ • 75% of neonatal males had partial unilateral cryptorchism

♂ • 25% of neonatal males had partial bilateral cryptorchism

♂ • all adult males had fully descended testes

bilateral cryptorchism ( J:55881 )

♂ • 25% of neonatal males had partial bilateral cryptorchism

unilateral cryptorchism ( J:55881 )

♂ • 75% of neonatal males had partial unilateral cryptorchism

reproductive system

cryptorchism ( J:55881 )

♂ • 75% of neonatal males had partial unilateral cryptorchism

♂ • 25% of neonatal males had partial bilateral cryptorchism

♂ • all adult males had fully descended testes

bilateral cryptorchism ( J:55881 )

♂ • 25% of neonatal males had partial bilateral cryptorchism

unilateral cryptorchism ( J:55881 )

♂ • 75% of neonatal males had partial unilateral cryptorchism

abnormal gubernaculum morphology ( J:55881 )

• delayed gubernacular regression

skeleton

abnormal gubernaculum morphology ( J:55881 )

• delayed gubernacular regression

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
cryptorchidism		DOID:11383	OMIM:219050	J:55881