Phenotypes associated with this allele

• Allele Symbol: Hoxc8^tm1Phb
• Allele Name: targeted mutation 1, Philippe Brulet
• Allele ID: MGI:2149030
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hoxc8^tm1Phb/Hoxc8^tm1Phb	either: (involves: 129) or (involves: 129S2/SvPas * C57BL/6 * DBA/2)	MGI:2172638
cx2	Hoxb8^tm1.1Jdes/Hoxb8^tm1.1Jdes Hoxc8^tm1Phb/?	involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * DBA/2 * FVB/N	MGI:3610487
cx3	Hoxb8^tm1.1Jdes/? Hoxc8^tm1Phb/Hoxc8^tm1Phb Hoxd8^tm1Jdes/Hoxd8^tm1Jdes	involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * DBA/2 * FVB/N	MGI:3610494
cx4	Hoxc8^tm1Phb/Hoxc8^tm1Phb Hoxd8^tm1Jdes/?	involves: 129S2/SvPas * C57BL/6 * DBA/2 * FVB/N	MGI:3610493

Genotype
MGI:2172638

hm1

• Allelic Composition: Hoxc8^tm1Phb/Hoxc8^tm1Phb
• Genetic Background: either: (involves: 129) or (involves: 129S2/SvPas * C57BL/6 * DBA/2)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:590 )

• most deaths within 5 days of birth due to inadequate caloric intake

• 6% survival past 6 weeks

skeleton

abnormal humerus morphology ( J:68720 )

abnormal deltoid tuberosity morphology ( J:68720 )

• deltoid crest slightly malformed

abnormal axial skeleton morphology ( J:590 )

• no transformations anterior to T6 or posterior to L2

abnormal sternum morphology ( J:590 )

increased sternebra number ( J:68720 )

• sometimes extra sternebra between 6th and 7th ribs

abnormal sternocostal joint morphology ( J:590 )

• attachment of rib 8 to sternum particularly when extra sternebra present

split xiphoid process ( J:590 )

• occasionally split lengthwise, particularly when rib 8 attachment to sternum was asymmetric

abnormal rib morphology ( J:590 )

• rib 12 similar in form to rib 11 in about 50% of mice

increased rib number ( J:590 , J:68720 )

• rudimentary or well developed L1 rib usually present (J:68720)

abnormal vertebrae morphology ( J:68720 )

abnormal thoracic vertebrae morphology ( J:590 , J:68720 )

• well developed processus transverses on T10 and T11 (J:590)

• abnormal dorsal processes (J:68720)

thoracic vertebral transformation ( J:68720 )

• T8 to T7 transformation in about 1/3 of mice

sacral vertebral transformation ( J:68720 )

• S1 to L6 transformation

limbs/digits/tail

camptodactyly ( J:590 )

• clenched digits on forelimbs

abnormal humerus morphology ( J:68720 )

abnormal deltoid tuberosity morphology ( J:68720 )

• deltoid crest slightly malformed

growth/size/body

decreased body size ( J:590 )

• at 5 months age

behavior/neurological

abnormal reflex ( J:590 )

abnormal gait ( J:590 )

• wavering movements

• walk on phalanges rather than on palm

muscle

muscle spasm ( J:590 )

• sometimes in hindlimbs or back muscles

Genotype
MGI:3610487

cx2

• Allelic Composition: Hoxb8^tm1.1Jdes/Hoxb8^tm1.1Jdes; Hoxc8^tm1Phb/?
• Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * DBA/2 * FVB/N

skeleton

abnormal axial skeleton morphology ( J:68720 )

• enhanced upper thoracic abnormalities

abnormal rib joint morphology ( J:68720 )

• less frequent 8th rib attachment to sternum

sacral vertebral transformation ( J:68720 )

• increased prevalence of S1 to L6 transformation

Genotype
MGI:3610494

cx3

• Allelic Composition: Hoxb8^tm1.1Jdes/?; Hoxc8^tm1Phb/Hoxc8^tm1Phb; Hoxd8^tm1Jdes/Hoxd8^tm1Jdes
• Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * DBA/2 * FVB/N

skeleton

abnormal thoracic cage morphology ( J:68720 )

• upper ribcage abnormalities are much more prevalent

asymmetric sternocostal joints ( J:68720 )

• bilateral attachment of extra ribs to sternum is less common

increased rib number ( J:68720 )

• presence of L1 ribs less prevalent

thoracic vertebral transformation ( J:68720 )

• T8 to T7 transformation less frequent and not as severe as when Hoxc8^tm1Phb only was mutated

Genotype
MGI:3610493

cx4

• Allelic Composition: Hoxc8^tm1Phb/Hoxc8^tm1Phb; Hoxd8^tm1Jdes/?
• Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2 * FVB/N

skeleton

increased rib number ( J:68720 )

• increased presence of fully developed L1 rib

abnormal vertebrae morphology ( J:68720 )

thoracic vertebral transformation ( J:68720 )

• increased penetrance and severity of T8 to T7 transformation

sacral vertebral transformation ( J:68720 )

• S1 to L6 transformation