Phenotypes associated with this allele

• Allele Symbol: Itgb5^tm1Des
• Allele Name: targeted mutation 1, Dean Sheppard
• Allele ID: MGI:2149063
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Itgb5^tm1Des/Itgb5^tm1Des	involves: 129S4/SvJae * C57BL/6J	MGI:3036535
cx2	Itgb3^tm1Hyn/Itgb3^tm1Hyn Itgb5^tm1Des/Itgb5^tm1Des	involves: 129S2/SvPas * 129S4/SvJae * C57BL/6	MGI:4438938

Genotype
MGI:3036535

hm1

• Allelic Composition: Itgb5^tm1Des/Itgb5^tm1Des
• Genetic Background: involves: 129S4/SvJae * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

normal phenotype

no abnormal phenotype detected ( J:59991 )

• homozygotes are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities

integument

abnormal keratinocyte differentiation ( J:59991 )

• cultured keratinocytes derived from homozygous animals display impaired adhesion and migration on vitronectin-coated surfaces

cellular

abnormal keratinocyte differentiation ( J:59991 )

• cultured keratinocytes derived from homozygous animals display impaired adhesion and migration on vitronectin-coated surfaces

Genotype
MGI:4438938

cx2

• Allelic Composition: Itgb3^tm1Hyn/Itgb3^tm1Hyn; Itgb5^tm1Des/Itgb5^tm1Des
• Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

neoplasm

abnormal tumor vascularization ( J:73752 )

• cell line derived tumors are significantly hyper-vascularized when compared with controls; however, vascular density in normal skin is not significantly different from controls

increased tumor growth/size ( J:73752 )

• tumor size is enhanced significantly when injected with murine melanoma (B16F0) or lung carcinoma (CMT19T) cells

cardiovascular system

abnormal tumor vascularization ( J:73752 )

• cell line derived tumors are significantly hyper-vascularized when compared with controls; however, vascular density in normal skin is not significantly different from controls