Phenotypes associated with this allele

• Allele Symbol: Add2^tm1Feb
• Allele Name: targeted mutation 1, Francisco E Baralle
• Allele ID: MGI:2149087
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Add2^tm1Feb/Add2^tm1Feb	B6.129-Add2^tm1Feb	MGI:3622414

Genotype
MGI:3622414

hm1

• Allelic Composition: Add2^tm1Feb/Add2^tm1Feb
• Genetic Background: B6.129-Add2^tm1Feb

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

increased spleen weight ( J:63047 )

• makes up 1% of total body weight rather than 0.3% as in controls

hematopoietic system

increased spleen weight ( J:63047 )

• makes up 1% of total body weight rather than 0.3% as in controls

anemia ( J:63047 )

• mild anemia with compensated hemolysis

decreased hematocrit ( J:63047 )

decreased hemoglobin content ( J:63047 )

decreased mean corpuscular hemoglobin ( J:63047 )

increased mean corpuscular hemoglobin concentration ( J:63047 )

• concentration increased as a result of smaller erythrocyte size

microcytosis ( J:63047 )

• erythrocytes are significantly smaller in size

poikilocytosis ( J:63047 )

• heterogeneity in erythrocyte shape

reticulocytosis ( J:63047 )

• increased reticulocyte count

increased erythrocyte osmotic fragility ( J:63047 )

• increased osmotic fragility, lyse at higher NaCl concentrations

cardiovascular system

increased pulse pressure ( J:71038 )

hypertension ( J:71038 )

increased systemic arterial diastolic blood pressure ( J:71038 )

increased systemic arterial systolic blood pressure ( J:71038 )

• significantly increased although no morphological or physiological differences can be detected in the heart

homeostasis/metabolism

increased circulating bilirubin level ( J:63047 )

• circulating levels slightly elevated

immune system

increased spleen weight ( J:63047 )

• makes up 1% of total body weight rather than 0.3% as in controls