All Phenotypes Hes5<tm1Fgu> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Hes5^tm1Fgu
targeted mutation 1, Francois Guillemot
MGI:2149674

Summary

9 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hes5^tm1Fgu/Hes5^tm1Fgu	involves: 129S1/Sv * 129X1/SvJ * CD-1	MGI:2172826
cn2	Emx1^tm1(cre)Ito/Emx1⁺ Hes1^tm1Fgu/Hes1^tm1Hojo Hes5^tm1Fgu/Hes5^tm1Fgu	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ	MGI:3713199
cn3	Hes1^tm1Kag/Hes1^tm1Kag Hes3^tm1Kag/Hes3^tm1Kag Hes5^tm1Fgu/Hes5^tm1Fgu Tg(Nes-cre/ERT2)5-1Imayo/0	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA	MGI:3808127
cn4	Emx1^tm1(cre)Ito/Emx1⁺ Hes1^tm1Kag/Hes1^tm1Kag Hes3^tm1Kag/Hes3^tm1Kag Hes5^tm1Fgu/Hes5^tm1Fgu	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA	MGI:3808125
cx5	Hes1^tm1Fgu/Hes1^tm1Fgu Hes5^tm1Fgu/Hes5^tm1Fgu	involves: 129S1/Sv * 129X1/SvJ	MGI:3808126
cx6	Hes1^tm1Fgu/Hes1⁺ Hes5^tm1Fgu/Hes5^tm1Fgu	involves: 129S1/Sv * 129X1/SvJ * CD-1	MGI:3617616
cx7	Hes1^tm1Fgu/Hes1^tm1Fgu Hes5^tm1Fgu/Hes5⁺	involves: 129S1/Sv * 129X1/SvJ * CD-1	MGI:3617615
cx8	Hes1^tm1Fgu/Hes1^tm1Fgu Hes3^tm1Kag/Hes3^tm1Kag Hes5^tm1Fgu/Hes5^tm1Fgu	involves: 129S1/Sv * 129X1/SvJ * CD-1	MGI:3526895
cx9	Hes1^tm1Fgu/Hes1^tm1Fgu Hes5^tm1Fgu/Hes5^tm1Fgu	involves: 129S1/Sv * 129X1/SvJ * CD-1	MGI:2172828

Allelic Composition	Hes5^tm1Fgu/Hes5^tm1Fgu
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * CD-1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hes5^tm1Fgu mutation (1 available); any Hes5 mutation (16 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

abnormal Muller cell morphology ( J:62537 )

• somehat reduced density of Muller glial cells at 7 and 14 days of age as well as in adults

• density reduction of about 30-40%

• no increase in apoptosis

hearing/vestibular/ear

increased cochlear inner hair cell number ( J:70081 )

• doublets of inner hair cells interspersed along the single row

increased cochlear outer hair cell number ( J:70081 )

• many areas with four outer hair cell rows rather than 3

abnormal inner ear vestibule morphology ( J:70081 )

increased vestibular hair cell number ( J:70081 )

• significant increase of hair cells on sensory epithelium of utricle and saccule (but to a lesser extent)

abnormal utricle morphology ( J:70081 )

abnormal vestibular saccule morphology ( J:70081 )

nervous system

abnormal Muller cell morphology ( J:62537 )

• somehat reduced density of Muller glial cells at 7 and 14 days of age as well as in adults

• density reduction of about 30-40%

• no increase in apoptosis

abnormal neuron morphology ( J:54662 )

• more Map2+ neurons in the brain and expression of Map2 by neurons was premature

increased cochlear inner hair cell number ( J:70081 )

• doublets of inner hair cells interspersed along the single row

increased cochlear outer hair cell number ( J:70081 )

• many areas with four outer hair cell rows rather than 3

increased vestibular hair cell number ( J:70081 )

• significant increase of hair cells on sensory epithelium of utricle and saccule (but to a lesser extent)

Allelic Composition	Emx1^tm1(cre)Ito/Emx1⁺ Hes1^tm1Fgu/Hes1^tm1Hojo Hes5^tm1Fgu/Hes5^tm1Fgu
Genetic Background	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Emx1^tm1(cre)Ito mutation (1 available); any Emx1 mutation (34 available)
Hes1^tm1Fgu mutation (1 available); any Hes1 mutation (23 available)
Hes1^tm1Hojo mutation (0 available); any Hes1 mutation (23 available)
Hes5^tm1Fgu mutation (1 available); any Hes5 mutation (16 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

abnormal pituitary gland morphology ( J:121843 )

• pituitary gland is sphere-shaped

• gland is composed of round cells only and lacks columnar cells

• cells expressing proopiomelanocortin (POMC) are all round, characteristic of pituitary anterior lobe cells whereas in wild-type, both round and columnar cells (in intermediate lobe) express POMC

increased somatotroph cell number ( J:121843 )

• growth hormone-producing cells are slightly increased in number

abnormal neurohypophysis morphology ( J:121843 )

• at E18, neurohypophysis is lost in mutants, but is formed normally in wild-type and Hes1-null animals

abnormal pituitary infundibular stalk morphology ( J:121843 )

• at E12.5, evagination of the infundibulum is affected compared to control embryos

abnormal pituitary gland development ( J:121843 )

• at E18, there are decreased numbers of pituitary gland progenitor cells compared to wild-type, shown by proliferation assays

• no apoptosis is observed

abnormal pituitary diverticulum morphology ( J:121843 )

• lumen of Rathke's pouch is absent

pituitary gland hypoplasia ( J:121843 )

• at E18, pituitary gland is severely hypoplastic

absent pituitary intermediate lobe ( J:121843 )

• intermediate lobe is absent

nervous system

abnormal pituitary gland morphology ( J:121843 )

• pituitary gland is sphere-shaped

• gland is composed of round cells only and lacks columnar cells

• cells expressing proopiomelanocortin (POMC) are all round, characteristic of pituitary anterior lobe cells whereas in wild-type, both round and columnar cells (in intermediate lobe) express POMC

increased somatotroph cell number ( J:121843 )

• growth hormone-producing cells are slightly increased in number

abnormal neurohypophysis morphology ( J:121843 )

• at E18, neurohypophysis is lost in mutants, but is formed normally in wild-type and Hes1-null animals

abnormal pituitary infundibular stalk morphology ( J:121843 )

• at E12.5, evagination of the infundibulum is affected compared to control embryos

abnormal pituitary gland development ( J:121843 )

• at E18, there are decreased numbers of pituitary gland progenitor cells compared to wild-type, shown by proliferation assays

• no apoptosis is observed

abnormal pituitary diverticulum morphology ( J:121843 )

• lumen of Rathke's pouch is absent

pituitary gland hypoplasia ( J:121843 )

• at E18, pituitary gland is severely hypoplastic

absent pituitary intermediate lobe ( J:121843 )

• intermediate lobe is absent

Allelic Composition	Hes1^tm1Kag/Hes1^tm1Kag Hes3^tm1Kag/Hes3^tm1Kag Hes5^tm1Fgu/Hes5^tm1Fgu Tg(Nes-cre/ERT2)5-1Imayo/0
Genetic Background	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hes1^tm1Kag mutation (2 available); any Hes1 mutation (23 available)
Hes3^tm1Kag mutation (2 available); any Hes3 mutation (18 available)
Hes5^tm1Fgu mutation (1 available); any Hes5 mutation (16 available)
Tg(Nes-cre/ERT2)5-1Imayo mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:139170 )

N	• mice exhibit no change in Cajal-Retzius cell number

Allelic Composition	Emx1^tm1(cre)Ito/Emx1⁺ Hes1^tm1Kag/Hes1^tm1Kag Hes3^tm1Kag/Hes3^tm1Kag Hes5^tm1Fgu/Hes5^tm1Fgu
Genetic Background	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Emx1^tm1(cre)Ito mutation (1 available); any Emx1 mutation (34 available)
Hes1^tm1Kag mutation (2 available); any Hes1 mutation (23 available)
Hes3^tm1Kag mutation (2 available); any Hes3 mutation (18 available)
Hes5^tm1Fgu mutation (1 available); any Hes5 mutation (16 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal neuron differentiation ( J:139170 )

• mice exhibit accelerated differentiation of neurons compared to in wild-type mice, including Cajal-Retzius cells in the dorsal telencephalon

abnormal embryonic neuroepithelium morphology ( J:139170 )

• unlike in wild-type mice, at E11.5 and E12.5 dorsal midline cells do not flatten and remain pseudostratified

abnormal brain morphology ( J:139170 )

• mice exhibit mild abnormalities in the cortical hem and cortical neuroepithelium

increased Cajal-Retzius cell number ( J:139170 )

• at E11.5 and E12.5, the number of Cajal-Retzius cells in the marginal zone of the piriform cortex is increased compared to in wild-type mice

absent choroid plexus ( J:139170 )

embryo

abnormal embryonic neuroepithelium morphology ( J:139170 )

• unlike in wild-type mice, at E11.5 and E12.5 dorsal midline cells do not flatten and remain pseudostratified

cellular

abnormal neuron differentiation ( J:139170 )

• mice exhibit accelerated differentiation of neurons compared to in wild-type mice, including Cajal-Retzius cells in the dorsal telencephalon

Allelic Composition	Hes1^tm1Fgu/Hes1^tm1Fgu Hes5^tm1Fgu/Hes5^tm1Fgu
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hes1^tm1Fgu mutation (1 available); any Hes1 mutation (23 available)
Hes5^tm1Fgu mutation (1 available); any Hes5 mutation (16 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal choroid plexus morphology ( J:139170 )

• at E10.5, the choroid plexus of the fourth ventricle is hypoplastic

Allelic Composition	Hes1^tm1Fgu/Hes1⁺ Hes5^tm1Fgu/Hes5^tm1Fgu
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * CD-1

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hearing/vestibular/ear

increased cochlear outer hair cell number ( J:70081 )

• significantly increased outer hair cell numbers relative to homozygotes or controls

nervous system

increased cochlear outer hair cell number ( J:70081 )

• significantly increased outer hair cell numbers relative to homozygotes or controls

Allelic Composition	Hes1^tm1Fgu/Hes1^tm1Fgu Hes5^tm1Fgu/Hes5⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * CD-1

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hearing/vestibular/ear

increased cochlear inner hair cell number ( J:70081 )

• significantly increased inner hair cell numbers relative to homozygotes or controls

nervous system

increased cochlear inner hair cell number ( J:70081 )

• significantly increased inner hair cell numbers relative to homozygotes or controls

Allelic Composition	Hes1^tm1Fgu/Hes1^tm1Fgu Hes3^tm1Kag/Hes3^tm1Kag Hes5^tm1Fgu/Hes5^tm1Fgu
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * CD-1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hes1^tm1Fgu mutation (1 available); any Hes1 mutation (23 available)
Hes3^tm1Kag mutation (2 available); any Hes3 mutation (18 available)
Hes5^tm1Fgu mutation (1 available); any Hes5 mutation (16 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

premature neuronal precursor differentiation ( J:94391 )

• at E8.5 many differentiated neurons have already formed unlike in Hes1, Hes5 double mutants where premature differentiation is not seen until E9.5

• at E9.5 almost all cells are neurons in the ventral spinal cord and at E10.0 virtually all radial glial cells have differentiated

cellular

premature neuronal precursor differentiation ( J:94391 )

• at E8.5 many differentiated neurons have already formed unlike in Hes1, Hes5 double mutants where premature differentiation is not seen until E9.5

• at E9.5 almost all cells are neurons in the ventral spinal cord and at E10.0 virtually all radial glial cells have differentiated

Allelic Composition	Hes1^tm1Fgu/Hes1^tm1Fgu Hes5^tm1Fgu/Hes5^tm1Fgu
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * CD-1

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, incomplete penetrance ( J:94391 )

• homozygous double mutants die by E11

nervous system

premature neuronal precursor differentiation ( J:94391 )

• at E9.5 and E10.5 radial glial cells prematurely differentiate into neurons resulting in failure of later born cells (oligodendrocytes, astrocytes, and ependymal cells) to be generated

• at E9.5 and E10.5 prematurely differentiated neurons are found in the regions where the optic vesicles should develop

abnormal neural tube morphology ( J:62024 , J:94391 )

• neural tube defects in 71.2% of embryos (J:62024)

• at E10.5 the cells of the neural tube are disorganized with many cells scattered across the lumen rather in contrast to the radial morphology seen in wild-type mice (J:94391)

• also at E10.5 the outer boundary of the neural tube is irregular and ambiguous (J:94391)

abnormal brain development ( J:94391 )

abnormal forebrain morphology ( J:94391 )

• the forebrain monotonous tube

abnormal ependyma morphology ( J:94391 )

• ependymal cells are absent

abnormal CNS glial cell morphology ( J:94391 )

abnormal astrocyte morphology ( J:94391 )

• astrocytes are absent

absent oligodendrocytes ( J:94391 )

• oligodendrocytes are absent

abnormal embryonic/fetal subventricular zone morphology ( J:94391 )

• the ganglionic eminences are not properly formed due to premature neuronal differentiation

neuron hypertrophy ( J:54662 )

• even greater neuron density in double homozygotes

abnormal dorsal root ganglion morphology ( J:94391 )

• neurons of the spinal cord and dorsal root ganglia are intermingled

abnormal spinal cord morphology ( J:94391 )

• the basal lamina is missing from the ventral spinal cord and neurons of the spinal cord and dorsal root ganglia are intermingled

vision/eye

absent optic vesicle ( J:94391 )

• at E9.5 and E10.5 the optic vesicles are absent; instead, differentiated neurons are found in the region that would normally become the optic vesicle

taste/olfaction

abnormal nasal placode morphology ( J:62024 )

• increased numbers of neurons in olfactory placodes at E10.5

growth/size/body

decreased embryo size ( J:54662 )

embryo

decreased embryo size ( J:54662 )

abnormal neural tube morphology ( J:62024 , J:94391 )

• neural tube defects in 71.2% of embryos (J:62024)

• at E10.5 the cells of the neural tube are disorganized with many cells scattered across the lumen rather in contrast to the radial morphology seen in wild-type mice (J:94391)

• also at E10.5 the outer boundary of the neural tube is irregular and ambiguous (J:94391)

respiratory system

abnormal nasal placode morphology ( J:62024 )

• increased numbers of neurons in olfactory placodes at E10.5

craniofacial

abnormal nasal placode morphology ( J:62024 )

• increased numbers of neurons in olfactory placodes at E10.5

cellular

premature neuronal precursor differentiation ( J:94391 )

• at E9.5 and E10.5 radial glial cells prematurely differentiate into neurons resulting in failure of later born cells (oligodendrocytes, astrocytes, and ependymal cells) to be generated

• at E9.5 and E10.5 prematurely differentiated neurons are found in the regions where the optic vesicles should develop

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