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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Irs4tm1Lhd
targeted mutation 1, Gustav E Lienhard
MGI:2149726
Summary 6 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Irs4tm1Lhd/Irs4tm1Lhd involves: 129S4/SvJae * BALB/c MGI:2663909
hm2
 		Irs4tm1Lhd/Irs4tm1Lhd involves: 129S4/SvJae * C57BL/6 MGI:2175217
cx3
 		Irs1tm1Jos/Irs1tm1Jos
Irs4tm1Lhd/Y 		involves: 129S2/SvPas * 129S4/SvJae * C57BL/6 MGI:3583265
cx4
 		Irs1tm1Jos/Irs1tm1Jos
Irs4tm1Lhd/Irs4tm1Lhd 		involves: 129S2/SvPas * 129S4/SvJae * C57BL/6 MGI:3583266
ot5
 		Irs4tm1Lhd/Y involves: 129S4/SvJae * BALB/c MGI:3583193
ot6
 		Irs4tm1Lhd/Y involves: 129S4/SvJae * C57BL/6 MGI:2175218


Genotype
MGI:2663909
hm1
Allelic
Composition		 Irs4tm1Lhd/Irs4tm1Lhd
Genetic
Background		 involves: 129S4/SvJae * BALB/c
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irs4tm1Lhd mutation (1 available); any Irs4 mutation (5 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
abnormal fertility/fecundity ( J:59964 )
• female homozygotes exhibit reduced ability to produce live offspring when mated with hemizygous mutant males
decreased litter size ( J:59964 )
• pairs of mutant mice produce an average of 2.0 0.5 litters per pair (range 0-3), whereas wild-type mice produce an average of 3.1 0.1 litters per pair (range 3-4)
• ~50% of mutant litters die within a few days of birth relative to only 8% of wild-type litters
• the average sizes of surviving litters are almost the same for mutant and wild-type mice




Genotype
MGI:2175217
hm2
Allelic
Composition		 Irs4tm1Lhd/Irs4tm1Lhd
Genetic
Background		 involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irs4tm1Lhd mutation (1 available); any Irs4 mutation (5 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
abnormal fertility/fecundity ( J:59964 )
• female homozygotes exhibit reduced ability to produce live offspring when mated with hemizygous mutant males
decreased litter size ( J:59964 )
• pairs of mutant mice produce an average of 1.8 0.4 litters per pair (range 0-3 litters) over a 3-month period, whereas wild-type mice produce an average of 2.9 0.1 litters per pair (range 2-3 litters)
• 36% of mutant litters die within a few days of birth relative to only 5% of wild-type litters
• the average size of surviving litters from mutant mice is slightly reduced relative to wild-type litters

behavior/neurological
abnormal maternal nurturing ( J:59964 )
• female homozygotes may be less nurturing of their pups than wild-type females, as suggested by an observed decrease in the number of surviving litters

homeostasis/metabolism
homeostasis/metabolism phenotype ( J:59964 )
N
• female homozygotes show slightly reduced blood glucose levels in both the fasted and fed states at 6-10 weeks, and in the fed state at 6 months; however, none of these differences reach statistical significance
• in addition, plasma insulin levels remain unaffected in the fed and fasted state at both ages
abnormal glucose tolerance ( J:59964 )
• at 6 months, older female homozygotes exhibit only a very slightly impaired glucose tolerance, which is statistically significant at 10 min but not at other time points

growth/size/body
growth/size/body region phenotype ( J:59964 )
N
• female homozygotes exhibit a very slight reduction in body size relative to wild-type mice; however, this difference does not reach statistical significance




Genotype
MGI:3583265
cx3
Allelic
Composition		 Irs1tm1Jos/Irs1tm1Jos
Irs4tm1Lhd/Y
Genetic
Background		 involves: 129S2/SvPas * 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irs1tm1Jos mutation (0 available); any Irs1 mutation (52 available)
Irs4tm1Lhd mutation (1 available); any Irs4 mutation (5 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
postnatal growth retardation ( J:80976 )
• these mutant males display no significant differences from Irs1tm1Jos homozygous males with respect to growth or organ size

homeostasis/metabolism
increased circulating insulin level ( J:80976 )
• at 10-17-weeks, these mutant males show no significant differences from Irs1tm1Jos homozygous males with respect to fed and fasted plasma insulin levels
impaired glucose tolerance ( J:80976 )
• at 9-12 weeks, double mutant males and Irs1tm1Jos homozygous males show no significant differences in fed and fasted blood glucose levels; both groups display a comparable (mild) reponse when subjected to glucose tolerance tests
insulin resistance ( J:80976 )
• at 9-12 weeks, double mutant males and Irs1tm1Jos homozygous males show a comparable (mild) reponse when subjected to insulin tolerance tests




Genotype
MGI:3583266
cx4
Allelic
Composition		 Irs1tm1Jos/Irs1tm1Jos
Irs4tm1Lhd/Irs4tm1Lhd
Genetic
Background		 involves: 129S2/SvPas * 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irs1tm1Jos mutation (0 available); any Irs1 mutation (52 available)
Irs4tm1Lhd mutation (1 available); any Irs4 mutation (5 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
postnatal growth retardation ( J:80976 )
• double homozygous females display no significant differences from Irs1tm1Jos homozygous females with respect to growth or organ size

homeostasis/metabolism
increased circulating insulin level ( J:80976 )
• at 10-17-weeks, double homozygous females show no significant differences from Irs1tm1Jos homozygous females with respect to fed and fasted plasma insulin levels
impaired glucose tolerance ( J:80976 )
• at 9-12 weeks, double mutant females and Irs1tm1Jos homozygous females show no significant differences in fed and fasted blood glucose levels; both groups display a comparable (mild) reponse when subjected to glucose tolerance tests
insulin resistance ( J:80976 )
• at 9-12 weeks, double mutant females and Irs1tm1Jos homozygous females show a comparable (mild) reponse when subjected to insulin tolerance tests




Genotype
MGI:3583193
ot5
Allelic
Composition		 Irs4tm1Lhd/Y
Genetic
Background		 involves: 129S4/SvJae * BALB/c
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irs4tm1Lhd mutation (1 available); any Irs4 mutation (5 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
impaired glucose tolerance ( J:59964 )
• at 6-10 weeks, male hemizygotes show an impaired tolerance that is statistically significant at the 60, 90, and 120 min time points of the oral glucose tolerance test

reproductive system
abnormal fertility/fecundity ( J:59964 )
• male hemizygotes exhibit reduced ability to produce live offspring when mated with homozygous mutant females
decreased litter size ( J:59964 )
• pairs of mutant mice produce an average of 2.0 0.5 litters per pair (range 0-3), whereas wild-type mice produce an average of 3.1 0.1 litters per pair (range 3-4)
• ~50% of mutant litters die within a few days of birth relative to only 8% of wild-type litters
• the average sizes of surviving litters are almost the same for mutant and wild-type mice




Genotype
MGI:2175218
ot6
Allelic
Composition		 Irs4tm1Lhd/Y
Genetic
Background		 involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irs4tm1Lhd mutation (1 available); any Irs4 mutation (5 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
decreased circulating glucose level ( J:59964 )
• at 6-10 weeks, male hemizygotes exhibit a slight but significant reduction in blood glucose levels in both the fasted and fed states; however, these differences become statistically insignificant at 6 months
• in contrast, plasma insulin levels remain unaffected in the fed and fasted state at both ages
impaired glucose tolerance ( J:59964 )
• at 6-10 weeks, male hemizygotes show a slightly impaired glucose tolerance, with significant differences noted at the 90 and 120 min time points
• at 6 months, significant differences are only noted at the 20 min point of the oral glucose tolerance test

reproductive system
abnormal fertility/fecundity ( J:59964 )
• male hemizygotes exhibit reduced ability to produce live offspring when mated with homozygous mutant females
decreased litter size ( J:59964 )
• pairs of mutant mice produce an average of 1.8 0.4 litters per pair (range 0-3 litters) over a 3-month period, whereas wild-type mice produce an average of 2.9 0.1 litters per pair (range 2-3 litters)
• 36% of mutant litters die within a few days of birth relative to only 5% of wild-type litters
• the average size of surviving litters from mutant mice is slightly reduced relative to wild-type litters

growth/size/body
decreased body weight ( J:59964 )
• at 9 weeks and beyond, the weight of male hemizygotes is ~10% less that of wild-type mice
postnatal growth retardation ( J:59964 )
• male hemizygotes exhibit a growth retardation beyond 6 weeks of age




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory