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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Juntm2.1Wag
targeted mutation 2.1, Erwin F Wagner
MGI:2149755
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Juntm2.1Wag/Juntm2.1Wag involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA MGI:2181275
cn2
 		Fbxw7tm1.1Axbe/Fbxw7tm1.1Axbe
Juntm2.1Wag/Juntm4Wag
Tg(En2-cre)22Alj/0 		involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ MGI:5293753


Genotype
MGI:2181275
hm1
Allelic
Composition		 Juntm2.1Wag/Juntm2.1Wag
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Juntm2.1Wag mutation (0 available); any Jun mutation (12 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
decreased body size ( J:53481 )
decreased body weight ( J:53481 )
• small decrease in body weight starting from the first week after birth that persists into adulthood

behavior/neurological
decreased susceptibility to pharmacologically induced seizures ( J:53481 )
• resistant to kainate-induced epileptic seizures, showing milder symptoms and quick recovery

cellular
decreased cellular sensitivity to ultraviolet irradiation ( J:53481 )
• cell death in response to ultraviolet irradiation, but not the alkylating agent MNNG, is reduced in fibroblasts
decreased susceptibility to neuronal excitotoxicity ( J:53481 )
• primary cortical/hippocampal neurons are protected from apoptosis induced by the excitatory amino acid, kainate
decreased cell proliferation ( J:53481 )
• primary fibroblasts exhibit a slower proliferation rate but do not enter premature senescence or show increased cell death

nervous system
decreased susceptibility to pharmacologically induced seizures ( J:53481 )
• resistant to kainate-induced epileptic seizures, showing milder symptoms and quick recovery
decreased susceptibility to neuronal excitotoxicity ( J:53481 )
• primary cortical/hippocampal neurons are protected from apoptosis induced by the excitatory amino acid, kainate

homeostasis/metabolism
decreased susceptibility to neuronal excitotoxicity ( J:53481 )
• primary cortical/hippocampal neurons are protected from apoptosis induced by the excitatory amino acid, kainate




Genotype
MGI:5293753
cn2
Allelic
Composition		 Fbxw7tm1.1Axbe/Fbxw7tm1.1Axbe
Juntm2.1Wag/Juntm4Wag
Tg(En2-cre)22Alj/0
Genetic
Background		 involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fbxw7tm1.1Axbe mutation (4 available); any Fbxw7 mutation (84 available)
Juntm2.1Wag mutation (0 available); any Jun mutation (12 available)
Juntm4Wag mutation (0 available); any Jun mutation (12 available)
Tg(En2-cre)22Alj mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal Purkinje cell morphology ( J:176598 )
• Purkinje cells exhibit partial rescue of organization and arborization compared with Fbxw7tm1.1Axbe/Fbxw7tm1.1Axbe Tg(En2-cre)22Alj mice
• however, Purkinje cell density is rescued




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory