All Phenotypes Otx2<tm2Asim> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Otx2^tm2Asim/Otx2^tm2Asim	involves: 129P2/OlaHsd * C57BL/6 * DBA/2	MGI:3845513
ht2	Otx2^tm1Pas/Otx2^tm2Asim	involves: 129P2/OlaHsd * C57BL/6 * DBA/2	MGI:3845514
cx3	Gbx2^tm1.1Mrt/Gbx2^tm1.1Mrt Otx2^tm1Pas/Otx2^tm2Asim	involves: 129 * C57BL/6 * DBA/2	MGI:3845546

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

reduced fertility ( J:71034 )

• 10% of mice exhibit reduced fertility

nervous system

open neural tube ( J:71034 )

• 54% of mice have moderate defects including exencephaly, lack of neural tube closure, or microencephaly with midbrain and forebrain reduction

abnormal brain development ( J:71034 )

• at E10.5, 65% of mice exhibit brain abnormalities of which 54% have moderate defects including exencephaly, lack of neural tube closure, or microencephaly with midbrain and forebrain reduction, and 11% have severe defects with heavy reduction of the forebrain and midbrain

abnormal forebrain development ( J:71034 )

• while forebrain territory is initially established it is not properly maintained

abnormal midbrain development ( J:71034 )

• while midbrain territory is initially established it is not properly maintained

decreased forebrain size ( J:71034 )

• the forebrain is reduced moderately to severely compared to in wild-type mice

decreased midbrain size ( J:71034 )

• the midbrain is reduced moderately to severely compared to in wild-type mice

anencephaly ( J:71034 )

• mice exhibit anencephalic features

exencephaly ( J:71034 )

• 54% of mice have moderate defects including exencephaly, lack of neural tube closure, or microencephaly with midbrain and forebrain reduction

behavior/neurological

abnormal motor capabilities/coordination/movement ( J:71034 )

• mice occasionally exhibit abnormal motor activity

embryo

open neural tube ( J:71034 )

• 54% of mice have moderate defects including exencephaly, lack of neural tube closure, or microencephaly with midbrain and forebrain reduction

growth/size/body

microcephaly ( J:71034 )

• 54% of mice have moderate defects including exencephaly, lack of neural tube closure, or microencephaly with midbrain and forebrain reduction

Allelic Composition	Otx2^tm1Pas/Otx2^tm2Asim
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Otx2^tm1Pas mutation (2 available); any Otx2 mutation (50 available)
Otx2^tm2Asim mutation (1 available); any Otx2 mutation (50 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal brain development ( J:71034 , J:72725 )

• at E10.5, 90% of mice exhibit severe and 10% moderate reductions in the rostral central nervous system (J:71034)

• at E8.7, mice lack anterior neural tissue (J:72725)

abnormal forebrain development ( J:71034 )

• while forebrain territory is initially established it is not properly maintained

abnormal midbrain development ( J:71034 )

• while midbrain territory is initially established it is not properly maintained

embryo

abnormal first pharyngeal arch morphology ( J:71034 )

• all mice exhibit abnormalities in the mandibular arch and its derivatives

craniofacial

abnormal maxillary prominence morphology ( J:71034 )

• all mice exhibit abnormalities in the maxillary process and its derivatives

abnormal first pharyngeal arch morphology ( J:71034 )

• all mice exhibit abnormalities in the mandibular arch and its derivatives

growth/size/body

acephaly ( J:71034 , J:72725 )

• at E16, 90% of embryos exhibit an almost headless phenotype with a morphologically undefined neural structure (J:71034)

• embryos are almost headless (J:72725)

Allelic Composition	Gbx2^tm1.1Mrt/Gbx2^tm1.1Mrt Otx2^tm1Pas/Otx2^tm2Asim
Genetic Background	involves: 129 * C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gbx2^tm1.1Mrt mutation (0 available); any Gbx2 mutation (27 available)
Otx2^tm1Pas mutation (2 available); any Otx2 mutation (50 available)
Otx2^tm2Asim mutation (1 available); any Otx2 mutation (50 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:72725 )

N	• mice are viable at E10.5

nervous system

abnormal brain development ( J:72725 )

• brain development is compromised

• however, mice exhibit rescue of the anterior defects observed in Otx2^{tm1(OTX1)Asim}/Otx2^tm1Pas heterozygotes

cardiovascular system

cardiovascular system phenotype ( J:72725 )

N	• heart development is normal

growth/size/body

abnormal head development ( J:72725 )

• head development is compromised

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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