All Phenotypes Otx2<tm2Asim> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Otx2^tm2Asim/Otx2^tm2Asim	involves: 129P2/OlaHsd * C57BL/6 * DBA/2	MGI:3845513
ht2	Otx2^tm1Pas/Otx2^tm2Asim	involves: 129P2/OlaHsd * C57BL/6 * DBA/2	MGI:3845514
cx3	Gbx2^tm1.1Mrt/Gbx2^tm1.1Mrt Otx2^tm1Pas/Otx2^tm2Asim	involves: 129 * C57BL/6 * DBA/2	MGI:3845546

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

reduced fertility ( J:71034 )

• 10% of mice exhibit reduced fertility

nervous system

open neural tube ( J:71034 )

• 54% of mice have moderate defects including exencephaly, lack of neural tube closure, or microencephaly with midbrain and forebrain reduction

abnormal brain development ( J:71034 )

• at E10.5, 65% of mice exhibit brain abnormalities of which 54% have moderate defects including exencephaly, lack of neural tube closure, or microencephaly with midbrain and forebrain reduction, and 11% have severe defects with heavy reduction of the forebrain and midbrain

abnormal forebrain development ( J:71034 )

• while forebrain territory is initially established it is not properly maintained

abnormal midbrain development ( J:71034 )

• while midbrain territory is initially established it is not properly maintained

decreased forebrain size ( J:71034 )

• the forebrain is reduced moderately to severely compared to in wild-type mice

decreased midbrain size ( J:71034 )

• the midbrain is reduced moderately to severely compared to in wild-type mice

anencephaly ( J:71034 )

• mice exhibit anencephalic features

exencephaly ( J:71034 )

• 54% of mice have moderate defects including exencephaly, lack of neural tube closure, or microencephaly with midbrain and forebrain reduction

behavior/neurological

abnormal motor capabilities/coordination/movement ( J:71034 )

• mice occasionally exhibit abnormal motor activity

embryo

open neural tube ( J:71034 )

• 54% of mice have moderate defects including exencephaly, lack of neural tube closure, or microencephaly with midbrain and forebrain reduction

growth/size/body

microcephaly ( J:71034 )

• 54% of mice have moderate defects including exencephaly, lack of neural tube closure, or microencephaly with midbrain and forebrain reduction

Allelic Composition	Otx2^tm1Pas/Otx2^tm2Asim
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Otx2^tm1Pas mutation (2 available); any Otx2 mutation (50 available)
Otx2^tm2Asim mutation (1 available); any Otx2 mutation (50 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal brain development ( J:71034 , J:72725 )

• at E10.5, 90% of mice exhibit severe and 10% moderate reductions in the rostral central nervous system (J:71034)

• at E8.7, mice lack anterior neural tissue (J:72725)

abnormal forebrain development ( J:71034 )

• while forebrain territory is initially established it is not properly maintained

abnormal midbrain development ( J:71034 )

• while midbrain territory is initially established it is not properly maintained

embryo

abnormal first pharyngeal arch morphology ( J:71034 )

• all mice exhibit abnormalities in the mandibular arch and its derivatives

craniofacial

abnormal maxillary prominence morphology ( J:71034 )

• all mice exhibit abnormalities in the maxillary process and its derivatives

abnormal first pharyngeal arch morphology ( J:71034 )

• all mice exhibit abnormalities in the mandibular arch and its derivatives

growth/size/body

acephaly ( J:71034 , J:72725 )

• at E16, 90% of embryos exhibit an almost headless phenotype with a morphologically undefined neural structure (J:71034)

• embryos are almost headless (J:72725)

Allelic Composition	Gbx2^tm1.1Mrt/Gbx2^tm1.1Mrt Otx2^tm1Pas/Otx2^tm2Asim
Genetic Background	involves: 129 * C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gbx2^tm1.1Mrt mutation (0 available); any Gbx2 mutation (27 available)
Otx2^tm1Pas mutation (2 available); any Otx2 mutation (50 available)
Otx2^tm2Asim mutation (1 available); any Otx2 mutation (50 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:72725 )

N	• mice are viable at E10.5

nervous system

abnormal brain development ( J:72725 )

• brain development is compromised

• however, mice exhibit rescue of the anterior defects observed in Otx2^{tm1(OTX1)Asim}/Otx2^tm1Pas heterozygotes

cardiovascular system

cardiovascular system phenotype ( J:72725 )

N	• heart development is normal

growth/size/body

abnormal head development ( J:72725 )

• head development is compromised

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24