Phenotypes associated with this allele

• Allele Symbol: Dpp4^tm1Nwa
• Allele Name: targeted mutation 1, Nicolai Wagtmann
• Allele ID: MGI:2150161
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dpp4^tm1Nwa/Dpp4^tm1Nwa	C57BL/6-Dpp4^tm1Nwa	MGI:2174945

Genotype
MGI:2174945

hm1

• Allelic Composition: Dpp4^tm1Nwa/Dpp4^tm1Nwa
• Genetic Background: C57BL/6-Dpp4^tm1Nwa

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

decreased body weight ( J:62709 )

• male homozygotes weigh slightly, but significantly, less than wild-type controls

homeostasis/metabolism

increased insulin secretion ( J:62709 )

• homozygotes display increased insulin secretion in association with increased levels of intact, biologically active GLP-1

increased circulating glucagon level ( J:62709 )

• in oral glucose tolerance tests, male homozygotes exhibit significantly higher plasma levels of intact, biologically active glucagon-like peptide 1 (GLP-1) than wild-type controls at 15 min after glucose challenge

• however, no significant differences are observed between wild-type and mutant mice in fasting levels of GLP-1

increased circulating insulin level ( J:62709 )

• in oral glucose tolerance tests, male homozygotes exhibit significantly higher plasma insulin levels than wild-type controls at 15 min after glucose challenge

• however, no significant differences are observed between wild-type and mutant mice in fasting levels of insulin

improved glucose tolerance ( J:62709 )

• in oral glucose tolerance tests, both male and female homozygotes exhibit significantly lower plasma glucose levels than wild-type mice at 15, 30 and 60 min after glucose challenge, indicating enhanced glucose clearance

• oral administration of valine-pyrrolidide (a specific pharmacological inhibitor of dipeptidylpeptidase 4 enzymatic activity) at 30 min before glucose challenge improves glucose tolerance in wild-type, but not in homozygous mutant mice

• no significant differences are observed between wild-type and mutant mice in fasting levels of glucose

endocrine/exocrine glands

increased insulin secretion ( J:62709 )

• homozygotes display increased insulin secretion in association with increased levels of intact, biologically active GLP-1