All Phenotypes Hoxa6<tm1Mrc> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Hoxa6^tm1Mrc
targeted mutation 1, Mario R Capecchi
MGI:2150392

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hoxa6^tm1Mrc/Hoxa6^tm1Mrc	involves: 129S7/SvEvBrd * C57BL/6J	MGI:3612178
cx2	Hoxa6^tm1Mrc/Hoxa6^tm1Mrc Hoxb6^tm1Mrc/Hoxb6^tm1Mrc Hoxc6^tm1Dds/Hoxc6^tm1Dds	involves: 129S7/SvEvBrd	MGI:4358349
cx3	Hoxa5^tm1Rob/Hoxa5⁺ Hoxa6^tm1Mrc/Hoxa6⁺ Hoxb5^tm1Mrc/Hoxb5⁺ Hoxb6^tm1Mrc/Hoxb6⁺ Hoxc5^tm1Mrc/Hoxc5⁺ Hoxc6^tm1Dds/Hoxc6⁺	involves: 129S/SvEv * 129S7/SvEvBrd	MGI:4358354

Allelic Composition	Hoxa6^tm1Mrc/Hoxa6^tm1Mrc
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxa6^tm1Mrc mutation (0 available); any Hoxa6 mutation (9 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

asymmetric rib joints ( J:19219 )

• rib attachements offset side to side in varying degrees in 2 of 72 mice

increased rib number ( J:19219 )

• C7 ribs fully formed in 5 of 72 mice

• dorsal part of C7 rib often fused to first thoracic rib but separates ventrally

• C7 rib transformations usually asymetric

• rarely heads on cervical ribs

thoracic vertebral transformation ( J:19219 )

• T1 with prominent processus spinosus (T2 characteristic) when C7 rib development is strong

• rare instances when T1 has a processus spinosus but T2 does not

abnormal cervical vertebrae morphology ( J:19219 )

• C7 normal with the exception of rib development

Allelic Composition	Hoxa6^tm1Mrc/Hoxa6^tm1Mrc Hoxb6^tm1Mrc/Hoxb6^tm1Mrc Hoxc6^tm1Dds/Hoxc6^tm1Dds
Genetic Background	involves: 129S7/SvEvBrd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxa6^tm1Mrc mutation (0 available); any Hoxa6 mutation (9 available)
Hoxb6^tm1Mrc mutation (0 available); any Hoxb6 mutation (14 available)
Hoxc6^tm1Dds mutation (0 available); any Hoxc6 mutation (11 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

abnormal sternebra morphology ( J:124112 )

• sternebra are poorly formed or missing

small xiphoid process ( J:124112 )

• reduced or absent

short sternum ( J:124112 )

abnormal rib joint morphology ( J:124112 )

• rib projections extend from T2 through T6 with ribs from T2 through T4 exhibiting the same angle as T1 ribs

decreased rib number ( J:124112 )

• mice are missing a complete first rib

rib fusion ( J:124112 )

• from T2 to T4

small thoracic cage ( J:124112 )

vertebral transformation ( J:124112 )

• mice exhibit anterior homeotic transformation from C6 to T6

• however, posterior thoracic, lumbar, and sacral vertebrae are normal in appearance and position

thoracic vertebral transformation ( J:124112 )

• T2 does not form a rib

• anterior projections do not begin until T4 and continue through T6 unlike in wild-type mice

cervical vertebral transformation ( J:124112 )

• C7 exhibit a vertebral foramina unlike in wild-type mice

Allelic Composition	Hoxa5^tm1Rob/Hoxa5⁺ Hoxa6^tm1Mrc/Hoxa6⁺ Hoxb5^tm1Mrc/Hoxb5⁺ Hoxb6^tm1Mrc/Hoxb6⁺ Hoxc5^tm1Mrc/Hoxc5⁺ Hoxc6^tm1Dds/Hoxc6⁺
Genetic Background	involves: 129S/SvEv * 129S7/SvEvBrd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxa5^tm1Rob mutation (1 available); any Hoxa5 mutation (27 available)
Hoxa6^tm1Mrc mutation (0 available); any Hoxa6 mutation (9 available)
Hoxb5^tm1Mrc mutation (0 available); any Hoxb5 mutation (11 available)
Hoxb6^tm1Mrc mutation (0 available); any Hoxb6 mutation (14 available)
Hoxc5^tm1Mrc mutation (0 available); any Hoxc5 mutation (12 available)
Hoxc6^tm1Dds mutation (0 available); any Hoxc6 mutation (11 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

abnormal skeleton morphology ( J:124112 )

• primaxial and abaxial skeleton defects are less severe than in either triple homozygote

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