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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Hoxb7tm1Mrc
targeted mutation 1, Mario R Capecchi
MGI:2150401
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Hoxb7tm1Mrc/Hoxb7tm1Mrc involves: 129S1/Sv * 129X1/SvJ MGI:2673163
cx2
 		Hoxa7tm1Mrc/Hoxa7tm1Mrc
Hoxb7tm1Mrc/Hoxb7+ 		involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ MGI:3611498
cx3
 		Hoxa7tm1Mrc/Hoxa7+
Hoxb7tm1Mrc/Hoxb7tm1Mrc 		involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ MGI:3611499
cx4
 		Hoxa7tm1Mrc/Hoxa7tm1Mrc
Hoxb7tm1Mrc/Hoxb7tm1Mrc 		involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ MGI:3611542


Genotype
MGI:2673163
hm1
Allelic
Composition		 Hoxb7tm1Mrc/Hoxb7tm1Mrc
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxb7tm1Mrc mutation (0 available); any Hoxb7 mutation (14 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
decreased sternebra number ( J:50942 )
• six rather than seven elements in the sternum of 12% of homozygotes, those with rib abnormalities
decreased rib number ( J:50942 )
• first rib pair reduced to small knobs in one out of 26 homozygotes
rib fusion ( J:50942 )
• 2 out of 26 homozygotes had the first and second ribs fused
• attachment to sternum was typical for first ribs




Genotype
MGI:3611498
cx2
Allelic
Composition		 Hoxa7tm1Mrc/Hoxa7tm1Mrc
Hoxb7tm1Mrc/Hoxb7+
Genetic
Background		 involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxa7tm1Mrc mutation (0 available); any Hoxa7 mutation (17 available)
Hoxb7tm1Mrc mutation (0 available); any Hoxb7 mutation (14 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
rib fusion ( J:50942 )
• one out of 11 had the first and second ribs fused




Genotype
MGI:3611499
cx3
Allelic
Composition		 Hoxa7tm1Mrc/Hoxa7+
Hoxb7tm1Mrc/Hoxb7tm1Mrc
Genetic
Background		 involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxa7tm1Mrc mutation (0 available); any Hoxa7 mutation (17 available)
Hoxb7tm1Mrc mutation (0 available); any Hoxb7 mutation (14 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
rib fusion ( J:50942 )
• 45% had first and second ribs fused




Genotype
MGI:3611542
cx4
Allelic
Composition		 Hoxa7tm1Mrc/Hoxa7tm1Mrc
Hoxb7tm1Mrc/Hoxb7tm1Mrc
Genetic
Background		 involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxa7tm1Mrc mutation (0 available); any Hoxa7 mutation (17 available)
Hoxb7tm1Mrc mutation (0 available); any Hoxb7 mutation (14 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
rib fusion ( J:50942 )
• 71% had first and second ribs fused

immune system
small thymus ( J:50942 )
• reduced size and altered shape but otherwise normal

hematopoietic system
small thymus ( J:50942 )
• reduced size and altered shape but otherwise normal

endocrine/exocrine glands
small thymus ( J:50942 )
• reduced size and altered shape but otherwise normal




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory