Analysis Tools|
Allele Symbol Allele Name Allele ID |
Hoxa9tm1Ipc targeted mutation 1, I Pierre Chambon MGI:2150411 |
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| Summary |
6 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• on vertebrae 21
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• lumbar vertebrae are anteriorized with extra ribs on vertebrae 21 indicating an L1 to T transformation
• vertebrae 21 through 25 are anteriorized
• however, L6 is normal
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• 60% of mice exhibit partial, and sometimes asymmetric, rib rudiments on L1
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• 60% of mice exhibit partial anteriorization with partial, and sometimes asymmetric, rib rudiments on L1
• 60% of mice exhibit unilateral or bilateral transformations of vertebrae 22 to 25
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• 5 out of 11 females are sterile
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• females produce small litters that often die one day after birth
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• 5 out of 10 males are sterile
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• abnormal humerus morphology are visible as early as P2
• the proximal head is flattened in some mice
• in some mice the articular surface of the head is abnormal
• some mice exhibit ectopic sesamoid bones in the elbow region with 5 of 14 mice exhibiting a small supernumery bone on the lateral side, 5 of 14 mice exhibiting a supernumerary sesamoid on the medial side, and 2 of 14 mice exhibiting a large supernumerary sesamoid along the crania side of the elbow joint
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• in some mice the deltoid is absent except for a distal rudiment consisting of either a small floating bone or bony protrusion
in some mice the deltoid is severely truncated
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• 15% to 20% shortened
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• mice exhibit an extra pair of ribs on vertebra 24
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• the articulation joining the ilium to the vertebral column is shifted half a vertebra
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• caudal vertebrae through Ca2 are anteriorized
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• mice exhibit anteriorization of L1 to T13 with an extra pair of ribs
• all lumbar vertebrae are anteriorized
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• sacral vertebrae are anteriorized
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• abnormal humerus morphology are visible as early as P2
• the proximal head is flattened in some mice
• in some mice the articular surface of the head is abnormal
• some mice exhibit ectopic sesamoid bones in the elbow region with 5 of 14 mice exhibiting a small supernumery bone on the lateral side, 5 of 14 mice exhibiting a supernumerary sesamoid on the medial side, and 2 of 14 mice exhibiting a large supernumerary sesamoid along the crania side of the elbow joint
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• in some mice the deltoid is absent except for a distal rudiment consisting of either a small floating bone or bony protrusion
in some mice the deltoid is severely truncated
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• 15% to 20% shortened
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• caudal vertebrae through Ca2 are anteriorized
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• some mice exhibit partial anteriorization of vertebrae 21 to 25
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• more affected than in Hoxd9tm1Ipc homozygotes
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• 12% to 15% of mice exhibit a reduction in humerus length that is between that observed in Hoxd9tm1Ipc homozygotes and Hoxa9tm1Ipc Hoxd9tm1Ipc homozygotes
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• 30% of mice exhibit the sum of vertebral column defects observed in Hoxd9tm1Ipc homozygotes and Hoxa9tm1Ipc heterozygotes
• 50% of mice exhibit vertebral column phenotypes observed in Hoxa9tm1Ipc Hoxd9tm1Ipc homozygotes
• 20% of mice exhibit unilateral transformation of vertebra 26 to L5, 27 to L6, and 28 to S1
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• 20% of mice exhibit anteriorization of vertebra 27 to L6
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• 20% of mice exhibit anteriorization of vertebra 28 and 29 to L6 and S1, respectively
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• more affected than in Hoxd9tm1Ipc homozygotes
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• 12% to 15% of mice exhibit a reduction in humerus length that is between that observed in Hoxd9tm1Ipc homozygotes and Hoxa9tm1Ipc Hoxd9tm1Ipc homozygotes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• 60% of mice exhibit vertebral column phenotypes observed in Hoxa9tm1Ipc homozygotes
40% of mice exhibit vertebral column phenotypes observed in Hoxa9tm1Ipc Hoxd9tm1Ipc homozygotes
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| N |
• mice exhibit normal humerus morphology
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/10/2024 MGI 6.24 |
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