All Phenotypes Hoxb9<tm1Mrc> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Hoxb9^tm1Mrc
targeted mutation 1, Mario R Capecchi
MGI:2150429

Summary

9 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hoxb9^tm1Mrc/Hoxb9^tm1Mrc	involves: 129S7/SvEvBrd	MGI:2178672
ht2	Hoxb9^tm1Mrc/Hoxb9⁺	involves: 129S7/SvEvBrd	MGI:2178673
cx3	Hoxa9^tm1Mrc/Hoxa9^tm1Mrc Hoxb9^tm1Mrc/Hoxb9^tm1Mrc	involves: 129S7/SvEvBrd	MGI:2178666
cx4	Hoxa9^tm1Mrc/Hoxa9⁺ Hoxb9^tm1Mrc/Hoxb9^tm1Mrc	involves: 129S7/SvEvBrd	MGI:3612546
cx5	Hoxa9^tm1Mrc/Hoxa9^tm1Mrc Hoxb9^tm1Mrc/Hoxb9^tm1Mrc Hoxc9^tm1Mrc/Hoxc9^tm1Mrc Hoxd9^tm1Mrc/Hoxd9^tm1Mrc	involves: 129S7/SvEvBrd	MGI:4358350
cx6	Hoxa9^tm1Mrc/Hoxa9^tm1Mrc Hoxb9^tm1Mrc/Hoxb9^tm1Mrc Hoxc9^tm1Mrc/Hoxc9⁺ Hoxd9^tm1Mrc/Hoxd9^tm1Mrc	involves: 129S7/SvEvBrd	MGI:4358353
cx7	Hoxa9^tm1Mrc/Hoxa9^tm1Mrc Hoxb9^tm1Mrc/Hoxb9^tm1Mrc Hoxd9^tm1Mrc/Hoxd9^tm1Mrc	Not Specified	MGI:3526127
cx8	Hoxa9^tm1Mrc/Hoxa9⁺ Hoxb9^tm1Mrc/Hoxb9^tm1Mrc Hoxd9^tm1Mrc/Hoxd9^tm1Mrc	Not Specified	MGI:3526128
cx9	Hoxa9^tm1Mrc/Hoxa9^tm1Mrc Hoxb9^tm1Mrc/Hoxb9⁺ Hoxd9^tm1Mrc/Hoxd9^tm1Mrc	Not Specified	MGI:3526129

Allelic Composition	Hoxb9^tm1Mrc/Hoxb9^tm1Mrc
Genetic Background	involves: 129S7/SvEvBrd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxb9^tm1Mrc mutation (0 available); any Hoxb9 mutation (12 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

abnormal thoracic cage morphology ( J:37847 )

• the upper rib cage is shortened by about 35%

abnormal sternebra morphology ( J:37847 )

• reduction in the number or intercostal segments of the sternum, and abnormal growth of the intercostal segments

abnormal sternocostal joint morphology ( J:37847 )

• abnormal attachment of the ribs to the sternum

increased rib number ( J:37847 )

• 54% exhibit an extra articulating eighth rib

rib fusion ( J:37847 )

• 83% exhibit fusions of first and second ribs, mostly bilateral

• majority of the rib fusions occur at the point of attachment with the sternum, with 25% of the fusions occurring by alternative pathways

vertebral transformation ( J:37847 )

• the articulation angle and position of sternal attachment of the second rib resembles those of the first rib

• the abnormal attachment of the 8th rib to the sternum can be regarded as the 8th rib acquiring 7th rib character

immune system

small thymus ( J:37847 )

• reduction in size and shape of thymus in those with rib fusions due to a decrease in rib cage size, however the medulla and cortex appear normal

hematopoietic system

small thymus ( J:37847 )

• reduction in size and shape of thymus in those with rib fusions due to a decrease in rib cage size, however the medulla and cortex appear normal

endocrine/exocrine glands

small thymus ( J:37847 )

• reduction in size and shape of thymus in those with rib fusions due to a decrease in rib cage size, however the medulla and cortex appear normal

Allelic Composition	Hoxb9^tm1Mrc/Hoxb9⁺
Genetic Background	involves: 129S7/SvEvBrd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxb9^tm1Mrc mutation (0 available); any Hoxb9 mutation (12 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

increased rib number ( J:37847 )

• 7.4% exhibit an extra articulating eighth rib

Allelic Composition	Hoxa9^tm1Mrc/Hoxa9^tm1Mrc Hoxb9^tm1Mrc/Hoxb9^tm1Mrc
Genetic Background	involves: 129S7/SvEvBrd

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

sternum hypoplasia ( J:37847 )

• sternum is hypoplastic and the length of all the intercostal segments is reduced and malformed

increased rib number ( J:37847 )

• 56% exhibit an extra articulating eighth rib

• 100% exhibit an extra pair of fully-grown ribs on the 21st vertebra

rib fusion ( J:37847 )

• 100 % exhibit bilateral fusions of first and second ribs that are more severe than in single homozygous mutant mice

• third rib fused to first and second rib fusion, incomplete penetrance

Allelic Composition	Hoxa9^tm1Mrc/Hoxa9⁺ Hoxb9^tm1Mrc/Hoxb9^tm1Mrc
Genetic Background	involves: 129S7/SvEvBrd

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

increased rib number ( J:37847 )

• 53% exhibit an extra articulating eighth rib

• 53% exhibit an extra pair of fully-grown ribs on the 21st vertebra

rib fusion ( J:37847 )

• 93% exhibit fusions of first and second ribs

Allelic Composition	Hoxa9^tm1Mrc/Hoxa9^tm1Mrc Hoxb9^tm1Mrc/Hoxb9^tm1Mrc Hoxc9^tm1Mrc/Hoxc9^tm1Mrc Hoxd9^tm1Mrc/Hoxd9^tm1Mrc
Genetic Background	involves: 129S7/SvEvBrd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxa9^tm1Mrc mutation (0 available); any Hoxa9 mutation (17 available)
Hoxb9^tm1Mrc mutation (0 available); any Hoxb9 mutation (12 available)
Hoxc9^tm1Mrc mutation (0 available); any Hoxc9 mutation (22 available)
Hoxd9^tm1Mrc mutation (0 available); any Hoxd9 mutation (16 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

decreased caudal vertebrae number ( J:124112 )

• two fewer than in wild-type mice

skeleton

decreased caudal vertebrae number ( J:124112 )

• two fewer than in wild-type mice

abnormal sternebra morphology ( J:124112 )

• mice lack distinct sternebrae unlike in wild-type mice

abnormal rib joint morphology ( J:124112 )

• the first rib does not always attach to the sternum unlike in wild-type mice

• rib attachment to the sternum continues past T7 to T13 and the transformed 'T14'

abnormal rib development ( J:124112 )

• posterior rib growth is abnormal with 4 vertebrae posterior to T13 forming ribs

rib fusion ( J:124112 )

• distal fusion of anterior-most ribs

small thoracic cage ( J:124112 )

abnormal sacral vertebrae morphology ( J:124112 )

• shifted posteriorly with displacement of pelvic attachment

vertebral transformation ( J:124112 )

• mice exhibit anterior homeotic transformations through the posterior thoracic skeleton and into the lumbar region

• the axial skeleton posterior to the transformations are shifted caudally by two vertebral segments

thoracic vertebral transformation ( J:124112 )

• T8 through L2 exhibit a T7-like phenotype

lumbar vertebral transformation ( J:124112 )

• T8 through L2 exhibit a T7-like phenotype

• L5 has an L3-like phenotype

abnormal sternum ossification ( J:124112 )

• the sternum is ossified and mispatterened along its entire anterior posterior length

Allelic Composition	Hoxa9^tm1Mrc/Hoxa9^tm1Mrc Hoxb9^tm1Mrc/Hoxb9^tm1Mrc Hoxc9^tm1Mrc/Hoxc9⁺ Hoxd9^tm1Mrc/Hoxd9^tm1Mrc
Genetic Background	involves: 129S7/SvEvBrd

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

abnormal rib joint morphology ( J:124112 )

• mice exhibit two extra ribbed vertebrae on T8 and T9 that attach to the sternum

abnormal thoracic vertebrae morphology ( J:124112 )

• mice exhibit two extra ribbed vertebrae on T8 and T9 that attach to the sternum

Allelic Composition	Hoxa9^tm1Mrc/Hoxa9^tm1Mrc Hoxb9^tm1Mrc/Hoxb9^tm1Mrc Hoxd9^tm1Mrc/Hoxd9^tm1Mrc
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxa9^tm1Mrc mutation (0 available); any Hoxa9 mutation (17 available)
Hoxb9^tm1Mrc mutation (0 available); any Hoxb9 mutation (12 available)
Hoxd9^tm1Mrc mutation (0 available); any Hoxd9 mutation (16 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

abnormal branching of the mammary ductal tree ( J:52279 )

• at day 12.5 of pregnancy branching of the epithelial ductal system is significantly reduced

mammary gland hypoplasia ( J:52279 )

• mammary glands in virgin females appear normal, however during and after pregnancy mammary gland hypoplasia as a result of a delay in growth and differentiation of the mammary epithelium is seen

• after parturition reduced numbers of lobuloalveolar structures and large amounts of intracellular fat droplets are seen

abnormal lactation ( J:52279 )

• mutant females have difficulty nursing pups with most pups dying shortly after birth of dehydration

integument

abnormal branching of the mammary ductal tree ( J:52279 )

• at day 12.5 of pregnancy branching of the epithelial ductal system is significantly reduced

mammary gland hypoplasia ( J:52279 )

• mammary glands in virgin females appear normal, however during and after pregnancy mammary gland hypoplasia as a result of a delay in growth and differentiation of the mammary epithelium is seen

• after parturition reduced numbers of lobuloalveolar structures and large amounts of intracellular fat droplets are seen

abnormal lactation ( J:52279 )

• mutant females have difficulty nursing pups with most pups dying shortly after birth of dehydration

Allelic Composition	Hoxa9^tm1Mrc/Hoxa9⁺ Hoxb9^tm1Mrc/Hoxb9^tm1Mrc Hoxd9^tm1Mrc/Hoxd9^tm1Mrc
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxa9^tm1Mrc mutation (0 available); any Hoxa9 mutation (17 available)
Hoxb9^tm1Mrc mutation (0 available); any Hoxb9 mutation (12 available)
Hoxd9^tm1Mrc mutation (0 available); any Hoxd9 mutation (16 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

mammary gland hypoplasia ( J:52279 )

• mammary glands in virgin females appear normal, however during and after pregnancy mammary gland hypoplasia as a result of a delay in growth and differentiation of the mammary epithelium is seen

• after parturition reduced numbers of lobuloalveolar structures and large amounts of intracellular fat droplets are seen

abnormal lactation ( J:52279 )

• mutant females have difficulty nursing pups with most pups dying shortly after birth of dehydration

integument

mammary gland hypoplasia ( J:52279 )

• mammary glands in virgin females appear normal, however during and after pregnancy mammary gland hypoplasia as a result of a delay in growth and differentiation of the mammary epithelium is seen

• after parturition reduced numbers of lobuloalveolar structures and large amounts of intracellular fat droplets are seen

abnormal lactation ( J:52279 )

• mutant females have difficulty nursing pups with most pups dying shortly after birth of dehydration

Allelic Composition	Hoxa9^tm1Mrc/Hoxa9^tm1Mrc Hoxb9^tm1Mrc/Hoxb9⁺ Hoxd9^tm1Mrc/Hoxd9^tm1Mrc
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxa9^tm1Mrc mutation (0 available); any Hoxa9 mutation (17 available)
Hoxb9^tm1Mrc mutation (0 available); any Hoxb9 mutation (12 available)
Hoxd9^tm1Mrc mutation (0 available); any Hoxd9 mutation (16 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

mammary gland hypoplasia ( J:52279 )

• mammary glands in virgin females appear normal, however during and after pregnancy mammary gland hypoplasia as a result of a delay in growth and differentiation of the mammary epithelium is seen

• after parturition reduced numbers of lobuloalveolar structures and large amounts of intracellular fat droplets are seen

abnormal lactation ( J:52279 )

• mutant females have difficulty nursing pups with most pups dying shortly after birth of dehydration

integument

mammary gland hypoplasia ( J:52279 )

• mammary glands in virgin females appear normal, however during and after pregnancy mammary gland hypoplasia as a result of a delay in growth and differentiation of the mammary epithelium is seen

• after parturition reduced numbers of lobuloalveolar structures and large amounts of intracellular fat droplets are seen

abnormal lactation ( J:52279 )

• mutant females have difficulty nursing pups with most pups dying shortly after birth of dehydration

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