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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Hoxa13tm1Ipc
targeted mutation 1, I Pierre Chambon
MGI:2150506
Summary 8 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Hoxa13tm1Ipc/Hoxa13tm1Ipc either: (involves: 129S2/SvPas) or (involves: 129S2/SvPas * C57BL/6) MGI:3721888
ht2
Hoxa13tm1Ipc/Hoxa13+ either: (involves: 129S2/SvPas) or (involves: 129S2/SvPas * C57BL/6) MGI:3721890
cx3
Hoxa13tm1Ipc/Hoxa13tm1Ipc
Hoxd13tm1Ddu/Hoxd13tm1Ddu
either: (involves: 129/Sv * 129S2/SvPas) or (involves: 129S2/SvPas * C57BL/6) MGI:3721899
cx4
Hoxa13tm1Ipc/Hoxa13+
Hoxd13tm1Ddu/Hoxd13+
either: (involves: 129/Sv * 129S2/SvPas) or (involves: 129S2/SvPas * C57BL/6) MGI:3721892
cx5
Hoxa13tm1Ipc/Hoxa13+
Hoxd13tm1Ddu/Hoxd13tm1Ddu
either: (involves: 129/Sv * 129S2/SvPas) or (involves: 129S2/SvPas * C57BL/6) MGI:3721895
cx6
Hoxa13tm1Ipc/Hoxa13tm1Ipc
Hoxd13tm1Ddu/Hoxd13+
either: (involves: 129/Sv * 129S2/SvPas) or (involves: 129S2/SvPas * C57BL/6) MGI:3721897
cx7
Hoxa13tm1Ipc/Hoxa13+
Hoxd13spdh/Hoxd13+
involves: 129S2/SvPas * C3HeB/FeJLe * C57BL/6J MGI:3802656
cx8
Hoxa13tm1Ipc/Hoxa13+
Hoxd13spdh/Hoxd13spdh
involves: 129S2/SvPas * C3HeB/FeJLe * C57BL/6J MGI:3802672


Genotype
MGI:3721888
hm1
Allelic
Composition
Hoxa13tm1Ipc/Hoxa13tm1Ipc
Genetic
Background
either: (involves: 129S2/SvPas) or (involves: 129S2/SvPas * C57BL/6)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxa13tm1Ipc mutation (0 available); any Hoxa13 mutation (29 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

limbs/digits/tail
• at E13.5, no distinct carpal condensation, with the exception of that for distal carpal 4, is detected
• at E15.5, the pyramidal is rudimentary, the central and distal carpals are poorly developed and there is no discernible scapholunatum cartilage
• at E13.5, the fibula remains connected to digit V in the hindlimbs mice lack digit I
• at E14.5, remaining digits are not properly separated
• at E15.5, digits II and V in the forelimb and all digits in the hindlimb lack the second phalanges cartilages
• at E15.5, digits II and V in the forelimb and all digits in the hindlimb lack the second phalanges cartilages
• digits II, III and V of the forelimbs and hindlimbs are reduced in size
• at E15.5, digits bend towards the anterior side
• at E14.5 and E15.5, digit 1 is absent from the forelimbs and hindlimbs
• at E15.5, webbing between digits II and III is present digit 1 is absent from the forelimbs and hindlimbs
• at E13.5, no tarsus elements are individualized and the fibula remains connected to digit V
• at E15.5, all tarsal elements are poorly modeled
• at E13.5, the fibula remains connected to digit V in the hindlimbs
• at E13.5, mice have only developed 4 digit anlagen
• at E13.5, no protrusion corresponding to digit 1 is evident and condensation for digit I is absent in the forelimbs and hindlimbs
• until E15.5, digit V in the hindlimb is a small and thin primary condensation but eventually develops normally
• at E12.5, the foot plates are narrower than in wild-type mice and abnormally flat along the anterior margin
• at E13.5, the foot plates are narrower than in wild-type mice and have only developed 4 digit anlagen

skeleton
• at E13.5, no distinct carpal condensation, with the exception of that for distal carpal 4, is detected
• at E15.5, the pyramidal is rudimentary, the central and distal carpals are poorly developed and there is no discernible scapholunatum cartilage
• at E15.5, digits II and V in the forelimb and all digits in the hindlimb lack the second phalanges cartilages
• at E13.5, no tarsus elements are individualized and the fibula remains connected to digit V
• at E15.5, all tarsal elements are poorly modeled
• at E13.5, the fibula remains connected to digit V in the hindlimbs




Genotype
MGI:3721890
ht2
Allelic
Composition
Hoxa13tm1Ipc/Hoxa13+
Genetic
Background
either: (involves: 129S2/SvPas) or (involves: 129S2/SvPas * C57BL/6)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxa13tm1Ipc mutation (0 available); any Hoxa13 mutation (29 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
limbs/digits/tail
• digit I shows an incomplete segmentation between the two phalangeal cartilages but no truncation
• in digit I of the hindlimb, the terminal phalanx has an altered bell-shaped morphology
• digit I shows an incomplete segmentation between the two phalangeal cartilages but no truncation
• in digit I of the hindlimb, the terminal phalanx has an altered bell-shaped morphology
• some mice have an interdigital fusion in digits II and III

skeleton
• digit I shows an incomplete segmentation between the two phalangeal cartilages but no truncation
• in digit I of the hindlimb, the terminal phalanx has an altered bell-shaped morphology




Genotype
MGI:3721899
cx3
Allelic
Composition
Hoxa13tm1Ipc/Hoxa13tm1Ipc
Hoxd13tm1Ddu/Hoxd13tm1Ddu
Genetic
Background
either: (involves: 129/Sv * 129S2/SvPas) or (involves: 129S2/SvPas * C57BL/6)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxa13tm1Ipc mutation (0 available); any Hoxa13 mutation (29 available)
Hoxd13tm1Ddu mutation (0 available); any Hoxd13 mutation (24 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• pups die between E11.5 and E15.5 similar to in Hoxa13tm1Ipc homozygotes

limbs/digits/tail
• at E12.5 to E14.5, autopods are round with no external sign of digit formation and are more truncated than in any Hoxa13tm1Ipc and/or Hoxd13tm1Ddu mice
• at E14.5, chondrogenic activity is diffuse throughout the hindlimb autopods and in two ill-defined areas in the forelimb autopods
• in one mouse that survived to E16.5, in the hindlimb there is a cartilage connection between the autopod and fibula
• in three mouse that survived to E16.5
• in three mouse that survived to E16.5
• in three mouse that survived to E16.5, in the hindlimb there is a cartilage connection between the autopod and fibula

growth/size/body

skeleton
• in three mouse that survived to E16.5
• in three mouse that survived to E16.5
• in three mouse that survived to E16.5, in the hindlimb there is a cartilage connection between the autopod and fibula

embryo




Genotype
MGI:3721892
cx4
Allelic
Composition
Hoxa13tm1Ipc/Hoxa13+
Hoxd13tm1Ddu/Hoxd13+
Genetic
Background
either: (involves: 129/Sv * 129S2/SvPas) or (involves: 129S2/SvPas * C57BL/6)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxa13tm1Ipc mutation (0 available); any Hoxa13 mutation (29 available)
Hoxd13tm1Ddu mutation (0 available); any Hoxd13 mutation (24 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
limbs/digits/tail
• in 50% of mice, the fourth posterior distal carpal bone is partly or fully split into two distinct bone
• digits I and V are deformed in the hinblimb
• digit I is more truncated than normal and no first phalanx is visible
• newborn mice show an incomplete segmentation between phalangeal cartilage in digit I
• digit I in the hindlimb has its first phalanx truncated and the terminal phalanx has an altered bell-shaped morphology
• the second phalanges of digits II and mostly in digit V are truncated in the forelimbs and hindlimbs
• digits II and III are fused and alterations in the claw of digit I are observeddigits II and III are fused and alterations in the claw of digit I are observed
• digit I lacks a first phalanx and newborn mice show an incomplete segmentation between the two phalangeal cartilages in forelimbs and in some hindlimbs
• digit I in the hindlimb has its first phalanx truncated and the terminal phalanx has an altered bell-shaped morphology
• the second phalanges of digits II and mostly in digit V are truncated in the forelimbs and hindlimbs
• in adults, digits I, II and V are truncated
• 23 of 40 mice have an extra posterior digit in the forelimbs consisting of either a small floating bone distal to the post minimus or an entire small digit
• in adults, digits III and IV are partially fused in the forelimbs and digits II, III and IV are completely fused in the hindlimbs
• the metatarsal of digit I is elongated

skeleton
• in 50% of mice, the fourth posterior distal carpal bone is partly or fully split into two distinct bone
• digit I lacks a first phalanx and newborn mice show an incomplete segmentation between the two phalangeal cartilages in forelimbs and in some hindlimbs
• digit I in the hindlimb has its first phalanx truncated and the terminal phalanx has an altered bell-shaped morphology
• the second phalanges of digits II and mostly in digit V are truncated in the forelimbs and hindlimbs
• the metatarsal of digit I is elongated




Genotype
MGI:3721895
cx5
Allelic
Composition
Hoxa13tm1Ipc/Hoxa13+
Hoxd13tm1Ddu/Hoxd13tm1Ddu
Genetic
Background
either: (involves: 129/Sv * 129S2/SvPas) or (involves: 129S2/SvPas * C57BL/6)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxa13tm1Ipc mutation (0 available); any Hoxa13 mutation (29 available)
Hoxd13tm1Ddu mutation (0 available); any Hoxd13 mutation (24 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
limbs/digits/tail
• digits of the forelimb autopods consists of short metacarpal/phalangeal bones fused together and terminal phalangeal-like structures are fused to form a common terminal arch
• the forelimb autopod is drastically truncated
• at one week of age, the cartilage has abnormally large central blastema and extra distal cartilage related to the presence of extra digits
• the distal carpals are fused
• terminal phalanges are partly fused in digits II through V in the hindlimbs
• at E18.5, forelimbs show selective truncation and delay in the ossification of digits II and V and a rudimentary posterior extra digit cartilage
• no individual metatarsal and phalangeal bones are observed in the hindlimbs
• terminal phalanges are partly fused in digits II through V in the hindlimbs of some mice
• at E18.5, forelimbs lack segmentation between certain metacarpals and first phalangeal cartilage
• digits of the forelimb autopods consists of short metacarpal/phalangeal bones fused together and terminal phalangeal-like structures are fused to form a common terminal arch
• no individual digits are observed and the extremities of the forepaws are a continuous ridge
• the distal tarsals are fused
• no individual metatarsal and phalangeal bones are observed in the hindlimbs
• at E18.5, forelimbs lack segmentation between certain metacarpals and first phalangeal cartilage
• at E13.5, an extra digit condensation is observed
• at E13.5, a central condensation is fused distally to one of its neighbors
• an abnormal condensation occurs between digit IV and V condensations
• at E14.5, a seventh posterior digit condensation is observed and a third digit condensation is prematurely truncated or joined distally to the second cartilage
• at E18.5, none of the digits become properly separated half of the mice have central digits fused with one or both of its neighbors
• the size of the digit cartilages decreases towards the anterior and posterior margins and the entire forefoot has a symmetrical round shape
• at E18.5, hindlimb digit cartilages are severely truncated and almost not segmented with terminal fusions
• at E18.5, forelimbs have seven non-ossified digits

skeleton
• at one week of age, the cartilage has abnormally large central blastema and extra distal cartilage related to the presence of extra digits
• the distal carpals are fused
• no individual metatarsal and phalangeal bones are observed in the hindlimbs
• terminal phalanges are partly fused in digits II through V in the hindlimbs of some mice
• at E18.5, forelimbs lack segmentation between certain metacarpals and first phalangeal cartilage
• the distal tarsals are fused
• no individual metatarsal and phalangeal bones are observed in the hindlimbs
• at E18.5, forelimbs lack segmentation between certain metacarpals and first phalangeal cartilage




Genotype
MGI:3721897
cx6
Allelic
Composition
Hoxa13tm1Ipc/Hoxa13tm1Ipc
Hoxd13tm1Ddu/Hoxd13+
Genetic
Background
either: (involves: 129/Sv * 129S2/SvPas) or (involves: 129S2/SvPas * C57BL/6)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxa13tm1Ipc mutation (0 available); any Hoxa13 mutation (29 available)
Hoxd13tm1Ddu mutation (0 available); any Hoxd13 mutation (24 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

limbs/digits/tail
• with the exception of an altered pisiform cartilage, there is no individualization of carpal condensation
• digits lack separation and segmentation and tend to fuse terminally
• mice lack digit I and some mice have a minute posterior extra digit cartilage
• the tarsus is altered more than in Hoxa13tm1Ipc/ Hoxa13+ Hoxd13tm1Ddu/Hoxd13tm1Ddu mice
• none of the tarsus blastemas are properly individualized and there is no separation between proximal and distal rows
• in the hindlimbs condensations for digits I through V are apparent but are irregular and remain in a primitive state
• in the hindlimbs, there is no chondrification in digit rays II and V
• foot plates are narrower, especially towards the distal extremities, when compared with Hoxa13tm1Ipc/ Hoxa13+ Hoxd13tm1Ddu/Hoxd13tm1Ddu mice

skeleton
• with the exception of an altered pisiform cartilage, there is no individualization of carpal condensation
• the tarsus is altered more than in Hoxa13tm1Ipc/ Hoxa13+ Hoxd13tm1Ddu/Hoxd13tm1Ddu mice
• none of the tarsus blastemas are properly individualized and there is no separation between proximal and distal rows




Genotype
MGI:3802656
cx7
Allelic
Composition
Hoxa13tm1Ipc/Hoxa13+
Hoxd13spdh/Hoxd13+
Genetic
Background
involves: 129S2/SvPas * C3HeB/FeJLe * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxa13tm1Ipc mutation (0 available); any Hoxa13 mutation (29 available)
Hoxd13spdh mutation (1 available); any Hoxd13 mutation (24 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
limbs/digits/tail
• absence of the second phalanges in digits II and V




Genotype
MGI:3802672
cx8
Allelic
Composition
Hoxa13tm1Ipc/Hoxa13+
Hoxd13spdh/Hoxd13spdh
Genetic
Background
involves: 129S2/SvPas * C3HeB/FeJLe * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxa13tm1Ipc mutation (0 available); any Hoxa13 mutation (29 available)
Hoxd13spdh mutation (1 available); any Hoxd13 mutation (24 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
limbs/digits/tail
• completely truncated autopod with barely recognizable very shortened digits that are fused laterally to each other

skeleton

vision/eye





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last database update
10/22/2024
MGI 6.24
The Jackson Laboratory