mortality/aging
• pups die between E11.5 and E15.5
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limbs/digits/tail
• at E13.5, no distinct carpal condensation, with the exception of that for distal carpal 4, is detected
• at E15.5, the pyramidal is rudimentary, the central and distal carpals are poorly developed and there is no discernible scapholunatum cartilage
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• at E13.5, the fibula remains connected to digit V in the hindlimbs
mice lack digit I
• at E14.5, remaining digits are not properly separated
• at E15.5, digits II and V in the forelimb and all digits in the hindlimb lack the second phalanges cartilages
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• at E15.5, digits II and V in the forelimb and all digits in the hindlimb lack the second phalanges cartilages
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brachydactyly
(
J:36214
)
• digits II, III and V of the forelimbs and hindlimbs are reduced in size
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clinodactyly
(
J:36214
)
• at E15.5, digits bend towards the anterior side
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oligodactyly
(
J:36214
)
• at E14.5 and E15.5, digit 1 is absent from the forelimbs and hindlimbs
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• at E15.5, webbing between digits II and III is present digit 1 is absent from the forelimbs and hindlimbs
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• at E13.5, no tarsus elements are individualized and the fibula remains connected to digit V
• at E15.5, all tarsal elements are poorly modeled
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• at E13.5, the fibula remains connected to digit V in the hindlimbs
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• at E13.5, mice have only developed 4 digit anlagen
• at E13.5, no protrusion corresponding to digit 1 is evident and condensation for digit I is absent in the forelimbs and hindlimbs
• until E15.5, digit V in the hindlimb is a small and thin primary condensation but eventually develops normally
|
• at E12.5, the foot plates are narrower than in wild-type mice and abnormally flat along the anterior margin
• at E13.5, the foot plates are narrower than in wild-type mice and have only developed 4 digit anlagen
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skeleton
• at E13.5, no distinct carpal condensation, with the exception of that for distal carpal 4, is detected
• at E15.5, the pyramidal is rudimentary, the central and distal carpals are poorly developed and there is no discernible scapholunatum cartilage
|
• at E15.5, digits II and V in the forelimb and all digits in the hindlimb lack the second phalanges cartilages
|
• at E13.5, no tarsus elements are individualized and the fibula remains connected to digit V
• at E15.5, all tarsal elements are poorly modeled
|
• at E13.5, the fibula remains connected to digit V in the hindlimbs
|