Analysis Tools
mortality/aging
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• only 10% of mice survive past weaning compared to the expected 25%
• however, after weaning mice exhibit normal lethality
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• most mice die prior to weaning likely between the first day or two after birth
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skeleton
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• unlike in wild-type mice, the eighth pair of ribs in 85% of mice is attached to the sternum
• however, the total number of ribs is normal
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• occasionally the fifth sternebra is smaller than normal
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short ribs
(
J:34198
)
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• the second and third pair of ribs is reduced in size compared to in wild-type mice
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• the processus spinosus of T2 is absent or greatly reduced compared to in wild-type mice
• unlike in wild-type mice, the dorsal process on T3 is larger than that on T2 in 97% of mice
• in one mouse the dorsal processes of T2 and T3 are the same size unlike in wild-type mice
• the transitional vertebra is T11 instead of T10 in wild-type mice
• T10 exhibits a thoracic type of articulation with T9 and T11 instead of the lumbar type of articulation between T10 and T11
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• T2 and T3 are transformed into T1 and T2
• in 4 of 8 mice T10 resembles T9
• occasionally T11 is transformed to T10
• in 3 mice, T10 is transformed towards T9 and T11 has an intermediate morphology between T10 and T11
• in one mouse T10 is transformed to T9 while T11 was fairly normal
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digestive/alimentary system
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• severely disorganized in dead newborn mice and moderately disorganized in other mice
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muscle
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• severely disorganized in dead newborn mice and moderately disorganized in other mice
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behavior/neurological
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• most mutant pups on the first day or two after birth exhibit little or no milk in the stomach
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