Phenotypes associated with this allele

• Allele Symbol: Hoxc9^tm1Hsu
• Allele Name: targeted mutation 1, Hirofumi Suemori
• Allele ID: MGI:2150685
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hoxc9^tm1Hsu/Hoxc9^tm1Hsu	involves: 129S/SvEv * A/J	MGI:2447619
ht2	Hoxc9^tm1Hsu/Hoxc9^+	involves: 129S/SvEv * A/J	MGI:2447618

Genotype
MGI:2447619

hm1

• Allelic Composition: Hoxc9^tm1Hsu/Hoxc9^tm1Hsu
• Genetic Background: involves: 129S/SvEv * A/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

postnatal growth retardation ( J:26535 )

• normal appearance at birth

• lower rates of weight gain

• noticeably smaller by 1 week of age

skeleton

abnormal sternum morphology ( J:26535 )

• sternebrae and xiphoid process fused to each other

asymmetric sternocostal joints ( J:26535 )

• 8-9 pairs of ribs attached to sternum rather than the more normal 7 pair

abnormal xiphoid process morphology ( J:26535 )

• sternebrae and xiphoid process fused to each other

increased rib number ( J:26535 )

• L1 ribs usually present, like T13 ribs in appearance

abnormal thoracic vertebrae morphology ( J:26535 )

• large transverse processes on T10-T13

kyphosis ( J:26535 )

• hunched back develops by 1 week of age

lumbar vertebral transformation ( J:26535 )

• L1 to T10 transformation

• caudal extending spinous process on all vertebrae anterior to L1

• vertebrae posterior to L1 all normal

Genotype
MGI:2447618

ht2

• Allelic Composition: Hoxc9^tm1Hsu/Hoxc9⁺
• Genetic Background: involves: 129S/SvEv * A/J

skeleton

skeleton phenotype ( J:26535 )

N • no abnormal ossifications between sternebrae

abnormal sternocostal joint morphology ( J:26535 )

• 8 pair of ribs attached to sternum in about 50% of mutants

thoracic vertebral transformation ( J:26535 )

• transitional vertebra T11 rather than T10

• caudal extending spinous process on all vertebrae anterior to T11