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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Hoxc6tm1Dds
targeted mutation 1, Demetri D Spyropoulos
MGI:2150689
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Hoxc6tm1Dds/Hoxc6tm1Dds involves: 129S7/SvEvBrd * C57BL/6 MGI:3611494
cx2
 		Hoxa6tm1Mrc/Hoxa6tm1Mrc
Hoxb6tm1Mrc/Hoxb6tm1Mrc
Hoxc6tm1Dds/Hoxc6tm1Dds 		involves: 129S7/SvEvBrd MGI:4358349
cx3
 		Hoxa5tm1Rob/Hoxa5+
Hoxa6tm1Mrc/Hoxa6+
Hoxb5tm1Mrc/Hoxb5+
Hoxb6tm1Mrc/Hoxb6+
Hoxc5tm1Mrc/Hoxc5+
Hoxc6tm1Dds/Hoxc6+ 		involves: 129S/SvEv * 129S7/SvEvBrd MGI:4358354


Genotype
MGI:3611494
hm1
Allelic
Composition		 Hoxc6tm1Dds/Hoxc6tm1Dds
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxc6tm1Dds mutation (0 available); any Hoxc6 mutation (11 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
thoracic vertebral transformation ( J:64980 )
• T2 transformed to a form similar to T1, 60% penetrance
• loss of processus spinosus on T2 or misplacement of T2 shaped processus spinosus to T3, 90% penetrance

endocrine/exocrine glands
abnormal inguinal mammary gland morphology ( J:64980 )
• inguinal mammary glands less severely affected but ductal structures dilated and variably oriented
• inguinal mammary glands with disorganized ductal epithelium
abnormal thoracic mammary gland morphology ( J:64980 )
• primary structures of thoracic mammary glands form but fail to expand with maturity
• thoracic mammary glands devoid of mammary epithelium
• absence of ductal structures in thoracic mammary glands of both females and males
abnormal mammary gland physiology ( J:64980 )
• unresponsive to hormone condition
• fail to regress in response to ovariectomy
abnormal lactation ( J:64980 )
• due to poor development of mammary glands
• results in death of some or all pups

integument
abnormal inguinal mammary gland morphology ( J:64980 )
• inguinal mammary glands less severely affected but ductal structures dilated and variably oriented
• inguinal mammary glands with disorganized ductal epithelium
abnormal thoracic mammary gland morphology ( J:64980 )
• primary structures of thoracic mammary glands form but fail to expand with maturity
• thoracic mammary glands devoid of mammary epithelium
• absence of ductal structures in thoracic mammary glands of both females and males
abnormal mammary gland physiology ( J:64980 )
• unresponsive to hormone condition
• fail to regress in response to ovariectomy
abnormal lactation ( J:64980 )
• due to poor development of mammary glands
• results in death of some or all pups




Genotype
MGI:4358349
cx2
Allelic
Composition		 Hoxa6tm1Mrc/Hoxa6tm1Mrc
Hoxb6tm1Mrc/Hoxb6tm1Mrc
Hoxc6tm1Dds/Hoxc6tm1Dds
Genetic
Background		 involves: 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxa6tm1Mrc mutation (0 available); any Hoxa6 mutation (9 available)
Hoxb6tm1Mrc mutation (0 available); any Hoxb6 mutation (14 available)
Hoxc6tm1Dds mutation (0 available); any Hoxc6 mutation (11 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
abnormal sternebra morphology ( J:124112 )
• sternebra are poorly formed or missing
small xiphoid process ( J:124112 )
• reduced or absent
abnormal rib joint morphology ( J:124112 )
• rib projections extend from T2 through T6 with ribs from T2 through T4 exhibiting the same angle as T1 ribs
decreased rib number ( J:124112 )
• mice are missing a complete first rib
rib fusion ( J:124112 )
• from T2 to T4
vertebral transformation ( J:124112 )
• mice exhibit anterior homeotic transformation from C6 to T6
• however, posterior thoracic, lumbar, and sacral vertebrae are normal in appearance and position
thoracic vertebral transformation ( J:124112 )
• T2 does not form a rib
• anterior projections do not begin until T4 and continue through T6 unlike in wild-type mice
cervical vertebral transformation ( J:124112 )
• C7 exhibit a vertebral foramina unlike in wild-type mice




Genotype
MGI:4358354
cx3
Allelic
Composition		 Hoxa5tm1Rob/Hoxa5+
Hoxa6tm1Mrc/Hoxa6+
Hoxb5tm1Mrc/Hoxb5+
Hoxb6tm1Mrc/Hoxb6+
Hoxc5tm1Mrc/Hoxc5+
Hoxc6tm1Dds/Hoxc6+
Genetic
Background		 involves: 129S/SvEv * 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxa5tm1Rob mutation (1 available); any Hoxa5 mutation (28 available)
Hoxa6tm1Mrc mutation (0 available); any Hoxa6 mutation (9 available)
Hoxb5tm1Mrc mutation (0 available); any Hoxb5 mutation (11 available)
Hoxb6tm1Mrc mutation (0 available); any Hoxb6 mutation (14 available)
Hoxc5tm1Mrc mutation (0 available); any Hoxc5 mutation (12 available)
Hoxc6tm1Dds mutation (0 available); any Hoxc6 mutation (11 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
abnormal skeleton morphology ( J:124112 )
• primaxial and abaxial skeleton defects are less severe than in either triple homozygote




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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory