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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Sema3ctm1.1Jra
targeted mutation 1.1, Jonathan A Raper
MGI:2150759
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Sema3ctm1.1Jra/Sema3ctm1.1Jra either: (involves: 129P2/OlaHsd) or (involves: 129P2/OlaHsd * C57BL/6) MGI:3032954
hm2
Sema3ctm1.1Jra/Sema3ctm1.1Jra involves: 129P2/OlaHsd * CD-1 MGI:3032956
cx3
Gucy2dtm1Mom/Gucy2dtm1Mom
Sema3ctm1.1Jra/Sema3ctm1.1Jra
involves: 129P2/OlaHsd * C57BL/6J MGI:3760750


Genotype
MGI:3032954
hm1
Allelic
Composition
Sema3ctm1.1Jra/Sema3ctm1.1Jra
Genetic
Background
either: (involves: 129P2/OlaHsd) or (involves: 129P2/OlaHsd * C57BL/6)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sema3ctm1.1Jra mutation (0 available); any Sema3c mutation (46 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice die within 24 hours of birth due to cardiac defects
• mortality rate less than 50% on both 129 and C57BL/6 backgrounds
• mortality rate increases on CD1 background with each successive backcross
• crossing heterozygotes from the fourth CD1 backcross generation results in 96% mortality




Genotype
MGI:3032956
hm2
Allelic
Composition
Sema3ctm1.1Jra/Sema3ctm1.1Jra
Genetic
Background
involves: 129P2/OlaHsd * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sema3ctm1.1Jra mutation (0 available); any Sema3c mutation (46 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice die within 24 hours of birth due to cardiac defects
• mortality rate less than 50% on both 129 and C57BL/6 backgrounds
• mortality rate increases on CD1 background with each successive backcross
• crossing heterozygotes from the fourth CD1 backcross generation results in 96% mortality

cardiovascular system
• aortic arch abnormalities involving interruptions between the left common carotid and left subclavian arteries (type B) or the brachiocephalic and left common carotid arteries (type C) occurred in all mice that died perinatally
• duplication of the left common carotid is infrequently observed
• seen in one mutant embryo
• defects detected in the membranous portion of the ventricular septum but not in the muscular septum

nervous system
N
• no misprojections of the cranial nerves were detected

embryo
• patterning of neural crest cells in the outflow tract of the heart is altered in mutant mice
• altered expression of Foxc1, endothelin receptor A, and plexinA2 suggests that neural crest cell invasion of the outflow tract is significantly impaired in mutant embryos

cellular
• patterning of neural crest cells in the outflow tract of the heart is altered in mutant mice
• altered expression of Foxc1, endothelin receptor A, and plexinA2 suggests that neural crest cell invasion of the outflow tract is significantly impaired in mutant embryos




Genotype
MGI:3760750
cx3
Allelic
Composition
Gucy2dtm1Mom/Gucy2dtm1Mom
Sema3ctm1.1Jra/Sema3ctm1.1Jra
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gucy2dtm1Mom mutation (1 available); any Gucy2d mutation (43 available)
Sema3ctm1.1Jra mutation (0 available); any Sema3c mutation (46 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
N
• olfactory bulb innervation is normal





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory