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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Sox10+
wild type
MGI:2151187
Summary 37 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Sox10M2J/Sox10+ B6Ei.Cg-Sox10M2J/GrsrJ MGI:5313550
ht2
 		Sox10Dom/Sox10+ C3Fe.B6JLe-Sox10Dom MGI:5897682
ht3
 		Sox10tm1Weg/Sox10+ C3HeB/FeJ-Sox10tm1Weg MGI:7461276
ht4
 		Sox10Dal/Sox10+ C57BL/6J-Sox10Dal MGI:3776043
ht5
 		Sox10Dom/Sox10+ C57BL/6J-Sox10Dom MGI:5897680
ht6
 		Sox10gt/Sox10+ GT/Le MGI:5648380
ht7
 		Sox10tm2(rtTA)Weg/Sox10+ involves: 129P2/OlaHsd MGI:3513122
ht8
 		Sox10tm8.1Weg/Sox10+ involves: 129P2/OlaHsd * C3H MGI:6154203
ht9
 		Sox10tm4Weg/Sox10+ involves: 129P2/OlaHsd * C3H MGI:3759673
ht10
 		Sox10tm5Weg/Sox10+ involves: 129P2/OlaHsd * C3H MGI:3759671
ht11
 		Sox10tm3(Sox8)Weg/Sox10+ involves: 129P2/OlaHsd * FVB/N MGI:3703448
ht12
 		Sox10tm1Weg/Sox10+ involves: 129S1/Sv * 129X1/SvJ MGI:3039430
ht13
 		Sox10tm1Weg/Sox10+ involves: 129S1/Sv * 129X1/SvJ * C3H MGI:6154211
ht14
 		Sox10tm1Weg/Sox10+ involves: 129S1/Sv * 129X1/SvJ * C3HeB/FeJ * C57BL/6J MGI:5552012
ht15
 		Sox10tm1Ngan/Sox10+ involves: 129S/SvEv * C57BL/6 MGI:7451333
ht16
 		Sox10df8R/Sox10+ involves: 129X1/SvJ * C57BL/6J MGI:3607576
ht17
 		Sox10df10R/Sox10+ involves: 129X1/SvJ * C57BL/6J MGI:3607575
ht18
 		Sox10Dom/Sox10+ involves: C3HeB/FeJLe * C57BL/6JLe MGI:5897676
ht19
 		Sox10Dom/Sox10+ involves: C57BL/6JLe MGI:3026747
ht20
 		Sox10gt/Sox10+ involves: HYIII/LeJ MGI:3052650
cn21
 		Sox10tm7.1(Sox10)Weg/Sox10+
Tg(Tyr-cre/ERT2)13Bos/0
Tg(Tyr-NRAS*Q61K)1Bee/0 		involves: 129P2/OlaHsd * C57BL/6J * DBA/2 * FVB/N MGI:5515811
cn22
 		Sox10tm1Ngan/Sox10+
Sox9tm2Crm/Sox9+
Tg(Rr141-cre)1Ksec/0 		involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6 * CBA MGI:7451336
cn23
 		Sox10tm1Ngan/Sox10+
Sox9tm1.1Ksec/Sox9+
Tg(Rr141-cre)1Ksec/0 		involves: 129S/SvEv * C57BL/6 * CBA MGI:7451340
cx24
 		Hprt1tm1(tetO-Runx1,-EGFP)Enk/Hprt1+
Sox10tm2(rtTA)Weg/Sox10+ 		involves: 129P2/OlaHsd MGI:4840038
cx25
 		Mos3/Mos3+
Sox10tm1Weg/Sox10+ 		involves: 129S1/Sv * 129X1/SvJ * BALB/c MGI:4462421
cx26
 		Rps7Zma/Rps7+
Sox10tm1Weg/Sox10+ 		involves: 129S1/Sv * 129X1/SvJ * BALB/c * C3H/HeH MGI:5500163
cx27
 		Smarcc1msp3/Smarcc1msp3
Sox10tm1Weg/Sox10+ 		involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6J MGI:3807572
cx28
 		Traf4m1Pav/Traf4m1Pav
Sox10tm1Weg/Sox10+ 		involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6J MGI:3807571
cx29
 		Smarca4mos6/Smarca4+
Sox10tm1Weg/Sox10+ 		involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6J MGI:6241342
cx30
 		Gli3Mos1/Gli3+
Sox10tm1Weg/Sox10+ 		involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6J MGI:3797124
cx31
 		msp4/msp4
Sox10tm1Weg/Sox10+ 		involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6J MGI:3807573
cx32
 		Erbb3msp1/Erbb3msp1
Sox10tm1Weg/Sox10+ 		involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6J MGI:3807570
cx33
 		Sox10tm1Weg/Sox10+
Tg(Sox10)#Sout/0 		involves: 129S1/Sv * 129X1/SvJ * C3HeB/FeJ * C57BL/6 * SJL MGI:7461278
cx34
 		Gli3Xt-J/Gli3+
Sox10tm1Weg/Sox10+ 		involves: 129S1/Sv * 129X1/SvJ * C3H/HeJ MGI:3797123
cx35
 		Sox10tm1Weg/Sox10+
Tg(Tyr-NRAS*Q61K)1Bee/0 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA/2 MGI:5515810
cx36
 		Cdkn2atm1Rdp/Cdkn2atm1Rdp
Sox10tm1Weg/Sox10+
Tg(Tyr-NRAS*Q61K)1Bee/0 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA/2 * SJL MGI:5515809
cx37
 		Sox10Dom/Sox10+
Tg(DBHn-lacZ)8Rpk/0 		involves: C3HeB/FeJLe * C57BL/6JLe * SJL MGI:5897678


Genotype
MGI:5313550
ht1
Allelic
Composition		 Sox10M2J/Sox10+
Genetic
Background		 B6Ei.Cg-Sox10M2J/GrsrJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox10M2J mutation (1 available); any Sox10 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
integument
variable body spotting ( J:181083 )
• heterozygotes on a non-agouti black background are spotted white and black with white feet, variable white regions on the tail, and white vibrissae in the regions of the face lacking pigmentation

pigmentation
variable body spotting ( J:181083 )
• heterozygotes on a non-agouti black background are spotted white and black with white feet, variable white regions on the tail, and white vibrissae in the regions of the face lacking pigmentation

limbs/digits/tail




Genotype
MGI:5897682
ht2
Allelic
Composition		 Sox10Dom/Sox10+
Genetic
Background		 C3Fe.B6JLe-Sox10Dom
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox10Dom mutation (1 available); any Sox10 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal enteric neural crest cell morphology ( J:165146 )
• decrease in the percentage of enteric neural crest-derived progenitors in the fetal gut at E12.5
abnormal enteric nervous system morphology ( J:165146 )
• decreased numbers of neuronal progenitor cells in the foregut at E13.5
• Background Sensitivity: increase in the number of myofibroblast-like cells compared to wild-type mice but increase is less than in heterozygous mice on a congenic B6JLe mice
abnormal enteric ganglia morphology ( J:165146 )
• abnormal patterning of the ganglion network in some mice at E13.5
• decreased density of enteric ganglia
• Background Sensitivity: ganglia are sparser in congenic B6 mice compared to congenic C3Fe mice

embryo
abnormal neural crest cell physiology ( J:165146 )
• shift in the types of colonies produced by cultured enteric neural crest-derived progenitors to produce more mixed glial and myofibroblast colonies and fewer mixed neuronal and glial colonies
abnormal enteric neural crest cell morphology ( J:165146 )
• decrease in the percentage of enteric neural crest-derived progenitors in the fetal gut at E12.5

cellular
abnormal neural crest cell physiology ( J:165146 )
• shift in the types of colonies produced by cultured enteric neural crest-derived progenitors to produce more mixed glial and myofibroblast colonies and fewer mixed neuronal and glial colonies




Genotype
MGI:7461276
ht3
Allelic
Composition		 Sox10tm1Weg/Sox10+
Genetic
Background		 C3HeB/FeJ-Sox10tm1Weg
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox10tm1Weg mutation (1 available); any Sox10 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
aganglionic megacolon ( J:296651 )
• hypo- or aganglionosis involving on average 3.1% of intestine length

integument

pigmentation
hypopigmentation ( J:296651 )
• white feet




Genotype
MGI:3776043
ht4
Allelic
Composition		 Sox10Dal/Sox10+
Genetic
Background		 C57BL/6J-Sox10Dal
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox10Dal mutation (1 available); any Sox10 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
pigmentation
variable body spotting ( J:132358 )
• Mice heterozygous for this mutation exhibit a classic black and white piebald coat

integument
variable body spotting ( J:132358 )
• Mice heterozygous for this mutation exhibit a classic black and white piebald coat




Genotype
MGI:5897680
ht5
Allelic
Composition		 Sox10Dom/Sox10+
Genetic
Background		 C57BL/6J-Sox10Dom
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox10Dom mutation (1 available); any Sox10 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
aganglionic megacolon ( J:165146 )
• mice with severe megacolon display regional increases in myofibroblast-like cells and decreases in glia

nervous system
abnormal enteric neural crest cell morphology ( J:165146 )
• decrease in the percentage of enteric neural crest-derived progenitors in the fetal gut at E12.5
abnormal enteric nervous system morphology ( J:165146 )
• decreased numbers of neuronal progenitor cells in the foregut at E13.5
• Background Sensitivity: increase in the number of myofibroblast-like cells compared to wild-type mice and heterozygous mice on a congenic C3Fe mice
abnormal enteric ganglia morphology ( J:165146 )
• abnormal patterning of the ganglion network in some mice at E13.5
• decreased density of enteric ganglia
• Background Sensitivity: ganglia are sparser in congenic B6 mice compared to congenic C3Fe mice
• large areas are devoid of normal enteric ganglia and instead contain large numbers of myofibroblast-like cells

embryo
abnormal neural crest cell physiology ( J:165146 )
• shift in the types of colonies produced by cultured enteric neural crest-derived progenitors to produce more neuronal and fewer glial, myofibroblast and mixed glial and myofibroblast colonies
abnormal enteric neural crest cell morphology ( J:165146 )
• decrease in the percentage of enteric neural crest-derived progenitors in the fetal gut at E12.5

cellular
abnormal neural crest cell physiology ( J:165146 )
• shift in the types of colonies produced by cultured enteric neural crest-derived progenitors to produce more neuronal and fewer glial, myofibroblast and mixed glial and myofibroblast colonies

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
Waardenburg syndrome type 4C DOID:0110955 OMIM:613266
 J:165146




Genotype
MGI:5648380
ht6
Allelic
Composition		 Sox10gt/Sox10+
Genetic
Background		 GT/Le
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox10gt mutation (0 available); any Sox10 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
brain vacuoles ( J:216967 )
• mild vacuolation, predominately in cerebellar, hindbrain, and thalamic white matter, is seen after 7 months of age




Genotype
MGI:3513122
ht7
Allelic
Composition		 Sox10tm2(rtTA)Weg/Sox10+
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox10tm2(rtTA)Weg mutation (0 available); any Sox10 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
pigmentation
belly spot ( J:94207 )
• with increasing numbers of backcrosses, nearly all heterozygotes developed a white belly spot

digestive/alimentary system
megacolon ( J:94207 )
• in early backcrosses, a few heterozygotes developed megacolon

integument
belly spot ( J:94207 )
• with increasing numbers of backcrosses, nearly all heterozygotes developed a white belly spot




Genotype
MGI:6154203
ht8
Allelic
Composition		 Sox10tm8.1Weg/Sox10+
Genetic
Background		 involves: 129P2/OlaHsd * C3H
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox10tm8.1Weg mutation (0 available); any Sox10 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
megacolon ( J:260791 )
• fewer than 5% of mice succumb to a megacolon around time of weaning

integument
belly spot ( J:260791 )
• fully penetrant white belly spot from second generation backcross to C3H and onwards

nervous system
abnormal oligodendrocyte physiology ( J:260791 )
• the number of Mbp and Plp-1 expressing oligodendrocytes are reduced in the spinal cord at P3 but not later times, indicating a slight and transient delay in oligodendroglial differentiation during the first postnatal days
• however, sciatic nerves, development and maintenance of Schwann cells and PNS myelin, and spinal cord development appear normal

pigmentation
belly spot ( J:260791 )
• fully penetrant white belly spot from second generation backcross to C3H and onwards




Genotype
MGI:3759673
ht9
Allelic
Composition		 Sox10tm4Weg/Sox10+
Genetic
Background		 involves: 129P2/OlaHsd * C3H
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox10tm4Weg mutation (0 available); any Sox10 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
digestive/alimentary phenotype ( J:124679 )
N
• unlike mice heterozygous for some other Sox10 alleles, mice do not develop agonglionic megacolon

pigmentation
belly spot ( J:124679 )
• from the second generation onwards, belly spots are observed on some mice

integument
belly spot ( J:124679 )
• from the second generation onwards, belly spots are observed on some mice




Genotype
MGI:3759671
ht10
Allelic
Composition		 Sox10tm5Weg/Sox10+
Genetic
Background		 involves: 129P2/OlaHsd * C3H
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox10tm5Weg mutation (0 available); any Sox10 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:124679 )
• unlike mice heterozygous for some other Sox10 alleles, mice do not develop megacolon or belly spots




Genotype
MGI:3703448
ht11
Allelic
Composition		 Sox10tm3(Sox8)Weg/Sox10+
Genetic
Background		 involves: 129P2/OlaHsd * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox10tm3(Sox8)Weg mutation (0 available); any Sox10 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
digestive/alimentary phenotype ( J:119015 )
N
• do not develop megacolon, unlike mice heterozygous for Sox10Dom or Sox10tm1Weg




Genotype
MGI:3039430
ht12
Allelic
Composition		 Sox10tm1Weg/Sox10+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox10tm1Weg mutation (1 available); any Sox10 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
brain vacuoles ( J:216967 )
• mild vacuolation in the brain is seen starting between 7 and 8 months of age




Genotype
MGI:6154211
ht13
Allelic
Composition		 Sox10tm1Weg/Sox10+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C3H
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox10tm1Weg mutation (1 available); any Sox10 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
megacolon ( J:260791 )
• fewer than 5% of mice succumb to a megacolon around time of weaning

nervous system
abnormal oligodendrocyte physiology ( J:260791 )
• the number of Mbp and Plp-1 expressing oligodendrocytes are reduced in the spinal cord at P3 but not later times, indicating a slight and transient delay in oligodendroglial differentiation during the first postnatal days
• however, sciatic nerves, development and maintenance of Schwann cells and PNS myelin, and spinal cord development appear normal

integument
belly spot ( J:260791 )
• white belly spot is fully penetrant from second generation backcross to C3H and onwards

pigmentation
belly spot ( J:260791 )
• white belly spot is fully penetrant from second generation backcross to C3H and onwards




Genotype
MGI:5552012
ht14
Allelic
Composition		 Sox10tm1Weg/Sox10+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C3HeB/FeJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox10tm1Weg mutation (1 available); any Sox10 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, incomplete penetrance ( J:67383 )
• in the fourth or subsequent generations of backcrosses with C3HeB/FeJ mice, a significant proportion of heterozygotes are lost during the first postnatal weeks; at weaning, only 38.2% of heterozygotes are seen instead of the expected 50% but expected numbers are seen perinatally

digestive/alimentary system
megacolon ( J:67383 )
• a fraction of heterozygotes from the fourth or subsequent generations of backcrosses with C3HeB/FeJ mice exhibit megacolon

integument
belly spot ( J:67383 )
• in the fourth or subsequent generations of backcrosses with C3HeB/FeJ mice, heterozygotes display a white belly spot

pigmentation
belly spot ( J:67383 )
• in the fourth or subsequent generations of backcrosses with C3HeB/FeJ mice, heterozygotes display a white belly spot
decreased melanocyte number ( J:67383 )
• melanocytes are reduced in numbers in mice from the fourth or subsequent generations of backcrosses with C3HeB/FeJ




Genotype
MGI:7451333
ht15
Allelic
Composition		 Sox10tm1Ngan/Sox10+
Genetic
Background		 involves: 129S/SvEv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox10tm1Ngan mutation (0 available); any Sox10 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hearing/vestibular/ear
dilated cochlea ( J:332093 )
• larger cross-section of basal cochlear lumen in E15.5 embryos




Genotype
MGI:3607576
ht16
Allelic
Composition		 Sox10df8R/Sox10+
Genetic
Background		 involves: 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox10df8R mutation (0 available); any Sox10 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
pigmentation
belly spot ( J:102039 )
• white belly spot of variable size sometimes seen, otherwise normal and fertile

integument
belly spot ( J:102039 )
• white belly spot of variable size sometimes seen, otherwise normal and fertile




Genotype
MGI:3607575
ht17
Allelic
Composition		 Sox10df10R/Sox10+
Genetic
Background		 involves: 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox10df10R mutation (0 available); any Sox10 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
pigmentation
belly spot ( J:102039 )
• variably sized white belly spot sometimes seen, otherwise normal and fertile

integument
belly spot ( J:102039 )
• variably sized white belly spot sometimes seen, otherwise normal and fertile




Genotype
MGI:5897676
ht18
Allelic
Composition		 Sox10Dom/Sox10+
Genetic
Background		 involves: C3HeB/FeJLe * C57BL/6JLe
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox10Dom mutation (1 available); any Sox10 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal neural crest cell migration ( J:45117 )
• delayed migration at E10.5 and E11.5

nervous system
abnormal enteric neuron morphology ( J:45117 )
• delayed enteric neuron colonization of the entire gut at E11

embryo
abnormal neural crest cell migration ( J:45117 )
• delayed migration at E10.5 and E11.5




Genotype
MGI:3026747
ht19
Allelic
Composition		 Sox10Dom/Sox10+
Genetic
Background		 involves: C57BL/6JLe
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox10Dom mutation (1 available); any Sox10 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
lethality at weaning, incomplete penetrance ( J:7688 )
• Background Sensitivity: survivability depends on genetic background with few mice surviving to weaning and dying soon thereafter on C57BL/6 and and 70 percent weaned from a B6C3 hybrid background

pigmentation
variable body spotting ( J:7688 )
• on belly and feet

digestive/alimentary system
megacolon ( J:7688 )
• distended colon is evident by 10 days of age
• myenteric ganglion cells of the midportion of the colon are reduced by 90 percent and are virtually absent in the distal one-half of the colon

integument
variable body spotting ( J:7688 )
• on belly and feet




Genotype
MGI:3052650
ht20
Allelic
Composition		 Sox10gt/Sox10+
Genetic
Background		 involves: HYIII/LeJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox10gt mutation (0 available); any Sox10 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
spongiform encephalopathy ( J:7723 )
• mild to moderate, asymptomatic, vacuolation found in gray matter by 59 days of age and older




Genotype
MGI:5515811
cn21
Allelic
Composition		 Sox10tm7.1(Sox10)Weg/Sox10+
Tg(Tyr-cre/ERT2)13Bos/0
Tg(Tyr-NRAS*Q61K)1Bee/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6J * DBA/2 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox10tm7.1(Sox10)Weg mutation (0 available); any Sox10 mutation (33 available)
Tg(Tyr-cre/ERT2)13Bos mutation (12 available)
Tg(Tyr-NRAS*Q61K)1Bee mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
pigmentation
pigmentation phenotype ( J:193443 )
N
• mice injected with tamoxifen at 2 months of age do not exhibit hyperpigmentation in the back skin, snout and paws at 12 months of age, indicating reversion of lesions that are seen in single Tg(Tyr-NRAS*Q61K)1Bee mutants




Genotype
MGI:7451336
cn22
Allelic
Composition		 Sox10tm1Ngan/Sox10+
Sox9tm2Crm/Sox9+
Tg(Rr141-cre)1Ksec/0
Genetic
Background		 involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox10tm1Ngan mutation (0 available); any Sox10 mutation (33 available)
Sox9tm2Crm mutation (1 available); any Sox9 mutation (33 available)
Tg(Rr141-cre)1Ksec mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hearing/vestibular/ear
dilated cochlea ( J:332093 )
• larger cross-section of basal cochlear lumen in E15.5 embryos




Genotype
MGI:7451340
cn23
Allelic
Composition		 Sox10tm1Ngan/Sox10+
Sox9tm1.1Ksec/Sox9+
Tg(Rr141-cre)1Ksec/0
Genetic
Background		 involves: 129S/SvEv * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox10tm1Ngan mutation (0 available); any Sox10 mutation (33 available)
Sox9tm1.1Ksec mutation (0 available); any Sox9 mutation (33 available)
Tg(Rr141-cre)1Ksec mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hearing/vestibular/ear
dilated cochlea ( J:332093 )
• ~2.7x larger cross-section of basal cochlear lumen in E15.5 embryos




Genotype
MGI:4840038
cx24
Allelic
Composition		 Hprt1tm1(tetO-Runx1,-EGFP)Enk/Hprt1+
Sox10tm2(rtTA)Weg/Sox10+
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hprt1tm1(tetO-Runx1,-EGFP)Enk mutation (0 available); any Hprt1 mutation (1280 available)
Sox10tm2(rtTA)Weg mutation (0 available); any Sox10 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, complete penetrance ( J:165939 )
• doxycycline-treated mice die 2 to 3 days after birth

nervous system
small dorsal root ganglion ( J:165939 )
• in doxycycline-treated mice

digestive/alimentary system
megacolon ( J:165939 )
• in doxycycline-treated mice

behavior/neurological
hyperresponsive to tactile stimuli ( J:165939 )
• in doxycycline-treated mice after a chronic constriction injury

growth/size/body
decreased birth body size ( J:165939 )
• in doxycycline-treated mice

pigmentation
abnormal skin pigmentation ( J:165939 )
• at birth in doxycycline-treated mice

integument
abnormal skin pigmentation ( J:165939 )
• at birth in doxycycline-treated mice




Genotype
MGI:4462421
cx25
Allelic
Composition		 Mos3/Mos3+
Sox10tm1Weg/Sox10+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * BALB/c
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mos3 mutation (0 available); any Mos3 mutation (0 available)
Sox10tm1Weg mutation (1 available); any Sox10 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
pigmentation
hypopigmentation ( J:136642 )
• increased ventral hypopigmentation compared to Sox10tm1Weg/+, and is accompanied by dorsal hypopigmentation




Genotype
MGI:5500163
cx26
Allelic
Composition		 Rps7Zma/Rps7+
Sox10tm1Weg/Sox10+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * BALB/c * C3H/HeH
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rps7Zma mutation (0 available); any Rps7 mutation (16 available)
Sox10tm1Weg mutation (1 available); any Sox10 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Rps7Zma/Rps7+ Sox10tm1Weg/Sox10+ embryos show greatly reduced melanoblast number at E12.5 as compared to E12.5 Sox10tm1Weg/Sox10+ mice

pigmentation
belly spot ( J:195156 )
• increased compared to in Rps7Zma heterozygotes
hypopigmentation ( J:195156 )
• increased compared to in Sox10tm1Weg heterozygotes without dark skin on the foot pads and tail

limbs/digits/tail

growth/size/body
decreased body size ( J:195156 )

nervous system
abnormal melanoblast morphology ( J:195156 )
• reduced numbers in the head and trunk at E12.5, more so than in Rps7Zma heterozygotes

integument
belly spot ( J:195156 )
• increased compared to in Rps7Zma heterozygotes

embryo
abnormal melanoblast morphology ( J:195156 )
• reduced numbers in the head and trunk at E12.5, more so than in Rps7Zma heterozygotes




Genotype
MGI:3807572
cx27
Allelic
Composition		 Smarcc1msp3/Smarcc1msp3
Sox10tm1Weg/Sox10+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smarcc1msp3 mutation (0 available); any Smarcc1 mutation (69 available)
Sox10tm1Weg mutation (1 available); any Sox10 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
preweaning lethality, complete penetrance ( J:138775 )
• no mice survive to weaning

nervous system

pigmentation

embryo




Genotype
MGI:3807571
cx28
Allelic
Composition		 Traf4m1Pav/Traf4m1Pav
Sox10tm1Weg/Sox10+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox10tm1Weg mutation (1 available); any Sox10 mutation (33 available)
Traf4m1Pav mutation (1 available); any Traf4 mutation (37 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
preweaning lethality, incomplete penetrance ( J:138775 )
• fewer than expected mice survive to weaning

pigmentation




Genotype
MGI:6241342
cx29
Allelic
Composition		 Smarca4mos6/Smarca4+
Sox10tm1Weg/Sox10+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smarca4mos6 mutation (0 available); any Smarca4 mutation (110 available)
Sox10tm1Weg mutation (1 available); any Sox10 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
pigmentation
belly spot ( J:241206 )
• adult double heterozygous mice exhibit more severe ventral white spotting than typically observed in single Sox10tm1Weg heterozygotes
head spot ( J:241206 )
• adult double heterozygous mice exhibit a head spot

integument
belly spot ( J:241206 )
• adult double heterozygous mice exhibit more severe ventral white spotting than typically observed in single Sox10tm1Weg heterozygotes
head spot ( J:241206 )
• adult double heterozygous mice exhibit a head spot

embryo
abnormal melanoblast morphology ( J:241206 )
• at E13.5, double heterozygous mice show a significant reduction of cranial melanoblast numbers relative to single Sox10tm1Weg heterozygotes

nervous system
abnormal melanoblast morphology ( J:241206 )
• at E13.5, double heterozygous mice show a significant reduction of cranial melanoblast numbers relative to single Sox10tm1Weg heterozygotes




Genotype
MGI:3797124
cx30
Allelic
Composition		 Gli3Mos1/Gli3+
Sox10tm1Weg/Sox10+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gli3Mos1 mutation (0 available); any Gli3 mutation (81 available)
Sox10tm1Weg mutation (1 available); any Sox10 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
pigmentation
belted ( J:136642 )
• mice exhibit an increased penetrance and severity of hypopigmentation compared to Sox10tm1Weg heterozygotes with ventral hypopigmentation that often extends onto the dorsal surface forming a belt in the lumbar region
belly spot ( J:136642 )
• mice exhibit ventral hypopigmentation
hypopigmentation ( J:136642 )
• mice exhibit an increased penetrance and severity of hypopigmentation compared to Sox10tm1Weg heterozygotes with ventral hypopigmentation that often extends onto the dorsal surface forming a belt in the lumbar region
• mice exhibit more hypopigmentation than in either single heterozygote

integument
belted ( J:136642 )
• mice exhibit an increased penetrance and severity of hypopigmentation compared to Sox10tm1Weg heterozygotes with ventral hypopigmentation that often extends onto the dorsal surface forming a belt in the lumbar region
belly spot ( J:136642 )
• mice exhibit ventral hypopigmentation




Genotype
MGI:3807573
cx31
Allelic
Composition		 msp4/msp4
Sox10tm1Weg/Sox10+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
msp4 mutation (0 available); any msp4 mutation (0 available)
Sox10tm1Weg mutation (1 available); any Sox10 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
preweaning lethality, incomplete penetrance ( J:138775 )
• fewer than expected mice survive to weaning

pigmentation




Genotype
MGI:3807570
cx32
Allelic
Composition		 Erbb3msp1/Erbb3msp1
Sox10tm1Weg/Sox10+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Erbb3msp1 mutation (0 available); any Erbb3 mutation (48 available)
Sox10tm1Weg mutation (1 available); any Sox10 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
lethality throughout fetal growth and development, incomplete penetrance ( J:138775 )
• fewer than expected mice are present at E12.5, E13.5, and E16.5
embryonic lethality during organogenesis, incomplete penetrance ( J:138775 )
• fewer than expected mice are present at E12.5, E13.5, and E16.5
preweaning lethality, complete penetrance ( J:138775 )
• no mice survive to weaning

pigmentation




Genotype
MGI:7461278
cx33
Allelic
Composition		 Sox10tm1Weg/Sox10+
Tg(Sox10)#Sout/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C3HeB/FeJ * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox10tm1Weg mutation (1 available); any Sox10 mutation (33 available)
Tg(Sox10)#Sout mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
digestive/alimentary phenotype ( J:296651 )
N
• no hypo- or aganglionosis of intestines

integument
integument phenotype ( J:296651 )
N
• no belly spot or white feet

pigmentation
pigmentation phenotype ( J:296651 )
N
• no belly spot or white feet




Genotype
MGI:3797123
cx34
Allelic
Composition		 Gli3Xt-J/Gli3+
Sox10tm1Weg/Sox10+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C3H/HeJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gli3Xt-J mutation (3 available); any Gli3 mutation (81 available)
Sox10tm1Weg mutation (1 available); any Sox10 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
pigmentation
belted ( J:136642 )
• mice exhibit an increased penetrance and severity of hypopigmentation compared to Sox10tm1Weg heterozygotes with ventral hypopigmentation that often extends onto the dorsal surface forming a belt in the lumbar region
belly spot ( J:136642 )
• mice exhibit ventral hypopigmentation
hypopigmentation ( J:136642 )
• mice exhibit an increased penetrance and severity of hypopigmentation compared to Sox10tm1Weg heterozygotes with ventral hypopigmentation that often extends onto the dorsal surface forming a belt in the lumbar region
• mice exhibit more hypopigmentation than in either single heterozygote

integument
belted ( J:136642 )
• mice exhibit an increased penetrance and severity of hypopigmentation compared to Sox10tm1Weg heterozygotes with ventral hypopigmentation that often extends onto the dorsal surface forming a belt in the lumbar region
belly spot ( J:136642 )
• mice exhibit ventral hypopigmentation




Genotype
MGI:5515810
cx35
Allelic
Composition		 Sox10tm1Weg/Sox10+
Tg(Tyr-NRAS*Q61K)1Bee/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox10tm1Weg mutation (1 available); any Sox10 mutation (33 available)
Tg(Tyr-NRAS*Q61K)1Bee mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
pigmentation
pigmentation phenotype ( J:193443 )
N
• hyperproliferation is not observed in the melanocytic cells localized to hair follicles as is seen in single Tg(Tyr-NRAS*Q61K)1Bee mutants




Genotype
MGI:5515809
cx36
Allelic
Composition		 Cdkn2atm1Rdp/Cdkn2atm1Rdp
Sox10tm1Weg/Sox10+
Tg(Tyr-NRAS*Q61K)1Bee/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA/2 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn2atm1Rdp mutation (6 available); any Cdkn2a mutation (67 available)
Sox10tm1Weg mutation (1 available); any Sox10 mutation (33 available)
Tg(Tyr-NRAS*Q61K)1Bee mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
pigmentation
pigmentation phenotype ( J:193443 )
N
• loss of the hyperpigmentation that is seen in Cdkn2atm1Rdp/ Cdkn2atm1Rdp Tg(Tyr-NRAS*Q61K)1Bee/0 mice resulting in an almost normal pigmentation pattern

neoplasm
neoplasm ( J:193443 )
N
• no signs of primary melanoma formation are seen at 6 months of age




Genotype
MGI:5897678
cx37
Allelic
Composition		 Sox10Dom/Sox10+
Tg(DBHn-lacZ)8Rpk/0
Genetic
Background		 involves: C3HeB/FeJLe * C57BL/6JLe * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox10Dom mutation (1 available); any Sox10 mutation (33 available)
Tg(DBHn-lacZ)8Rpk mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
abnormal intestine morphology ( J:32868 )
• Background Sensitivity: phenotype is more severe when crossed to C57BL/6J females with all offspring completely lacking ganglion cells in the distal large intestine compared to only 1/3 of offspring from crosses to C3HeB/FeJ females
• Background Sensitivity: in crosses to C3HeB/FeJ females the other 2/3 of offspring have reduced numbers of ganglion or no detectable changes in ganglion numbers
• hypoganglionosis without aganglionosis is confined to the distal 1-2 cm of the adult colon
abnormal colon morphology ( J:32868 )
• hypoganglionosis without aganglionosis is confined to the distal 1-2 cm of the adult colon
abnormal rectum morphology ( J:32868 )
• aganglionosis or hypoganglionosis always involves the distal rectum

integument
white spotting ( J:32868 )
• almost all have one or more white paws
• more than half have ventral white spots

cellular
abnormal vagal neural crest cell migration ( J:32868 )
• delayed colonization of the intestine by vagal neural crest cells between E11.0 to E13.5
• reduced density of neuroblasts in the intestine between E11.0 to E13.5 especially near the migration front

nervous system
abnormal parasympathetic ganglion morphology ( J:32868 )
• almost all display aganglionosis or hypoganglionosis
• Background Sensitivity: phenotype is more severe when crossed to C57BL/6J females with all offspring completely lacking ganglion cells in the distal large intestine compared to only 1/3 of offspring from crosses to C3HeB/FeJ females
• Background Sensitivity: in crosses to C3HeB/FeJ females the other 2/3 of offspring have reduced numbers of ganglion or no detectable changes in ganglion numbers
• aganglionic segements of the large intestine lack both myenteric and submucosal ganglion cells

embryo
abnormal vagal neural crest cell migration ( J:32868 )
• delayed colonization of the intestine by vagal neural crest cells between E11.0 to E13.5
• reduced density of neuroblasts in the intestine between E11.0 to E13.5 especially near the migration front

pigmentation
white spotting ( J:32868 )
• almost all have one or more white paws
• more than half have ventral white spots




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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory