About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Hoxb4tm2Bay
targeted mutation 2, Baylor College of Medicine
MGI:2151429
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Hoxb4tm2Bay/Hoxb4tm2Bay involves: 129S7/SvEvBrd * C57BL/6J MGI:2673172


Genotype
MGI:2673172
hm1
Allelic
Composition
Hoxb4tm2Bay/Hoxb4tm2Bay
Genetic
Background
involves: 129S7/SvEvBrd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxb4tm2Bay mutation (0 available); any Hoxb4 mutation (20 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
N
• unlike Hoxb4tm1Bay mutant mice, most or all homozygotes survive to adulthood

skeleton
N
• unlike Hoxb4tm1Bay mutant mice, all homozygotes display a normal sternum
• 20% of homozygotes show an extra ventral tubercle on the cervical axis (C2)
• 50% of homozygotes display broadening of the neural arch of C2, which is normally typical of C1
• some homozygotes display a partial anterior homeotic transformation of the second cervical vertebra or axis (C2) to atlas (C1)

growth/size/body
N
• unlike Hoxb4tm1Bay mutant mice, adult homozygotes are normal in size

muscle
N
• unlike Hoxb4tm1Bay mutant mice, adult homozygotes display normal visceral morphology, with no detectable diaphragmatic hernias or eventrations





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
12/10/2024
MGI 6.24
The Jackson Laboratory