All Phenotypes Hoxb5<tm1Mrc> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Hoxb5^tm1Mrc
targeted mutation 1, Mario R Capecchi
MGI:2151484

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hoxb5^tm1Mrc/Hoxb5^tm1Mrc	involves: 129S7/SvEvBrd	MGI:2673167
cx2	Hoxb5^tm1Mrc/Hoxb5⁺ Hoxb6^tm1Mrc/Hoxb6⁺	involves: 129S7/SvEvBrd	MGI:3611769
cx3	Hoxa5^tm1Rob/Hoxa5^tm1Rob Hoxb5^tm1Mrc/Hoxb5^tm1Mrc Hoxc5^tm1Mrc/Hoxc5^tm1Mrc	involves: 129S/SvEv * 129S7/SvEvBrd	MGI:4358348
cx4	Hoxa5^tm1Rob/Hoxa5⁺ Hoxa6^tm1Mrc/Hoxa6⁺ Hoxb5^tm1Mrc/Hoxb5⁺ Hoxb6^tm1Mrc/Hoxb6⁺ Hoxc5^tm1Mrc/Hoxc5⁺ Hoxc6^tm1Dds/Hoxc6⁺	involves: 129S/SvEv * 129S7/SvEvBrd	MGI:4358354

Allelic Composition	Hoxb5^tm1Mrc/Hoxb5^tm1Mrc
Genetic Background	involves: 129S7/SvEvBrd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxb5^tm1Mrc mutation (0 available); any Hoxb5 mutation (11 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

abnormal pectoral girdle bone morphology ( J:22424 )

• forelimbs shifted anteriorly relative to the axial skeleton

• shift of limbs sometimes is unilateral

abnormal scapula morphology ( J:22424 )

• rostral edge of the scapula aligns with C3 or C4 rather than C5

abnormal vertebrae morphology ( J:22424 )

abnormal thoracic vertebrae morphology ( J:22424 )

• altered lateral processes on T1

thoracic vertebral transformation ( J:22424 )

• T1 to C7 transformation the most prevalent vertebral abnormality

cervical vertebral transformation ( J:22424 )

• C7 to C6 transformation

• tuberculum anterior of C6 either shifted to C7 (C6 to C5 transformation) or duplicated there

nervous system

abnormal somatic nervous system morphology ( J:22424 )

• brachial plexus enters the forelimb at a more posterior position than in controls

Allelic Composition	Hoxb5^tm1Mrc/Hoxb5⁺ Hoxb6^tm1Mrc/Hoxb6⁺
Genetic Background	involves: 129S7/SvEvBrd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxb5^tm1Mrc mutation (0 available); any Hoxb5 mutation (11 available)
Hoxb6^tm1Mrc mutation (0 available); any Hoxb6 mutation (14 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

thoracic vertebral transformation ( J:22424 )

• T1 to C7 transformation frequent

cervical vertebral transformation ( J:22424 )

• C6 to C5 and/or C7 to C6 transformation in 52% of double heterozygotes

• occurs in the absence of T1 to C7 transformations

Allelic Composition	Hoxa5^tm1Rob/Hoxa5^tm1Rob Hoxb5^tm1Mrc/Hoxb5^tm1Mrc Hoxc5^tm1Mrc/Hoxc5^tm1Mrc
Genetic Background	involves: 129S/SvEv * 129S7/SvEvBrd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxa5^tm1Rob mutation (1 available); any Hoxa5 mutation (28 available)
Hoxb5^tm1Mrc mutation (0 available); any Hoxb5 mutation (11 available)
Hoxc5^tm1Mrc mutation (0 available); any Hoxc5 mutation (12 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

abnormal axial skeleton morphology ( J:124112 )

• the clavicles are attached to the rib cage by connective tissue and do not articulate directly with it unlike in wild-type mice

absent sternal manubrium ( J:124112 )

short sternum ( J:124112 )

abnormal rib joint morphology ( J:124112 )

• a eighth rib is attached to the sternum unlike in wild-type mice

• T1 ribs exhibit incomplete projection and T2 ribs extend but often do not reach the sternum (in 64% of mice)

• however, rib attachment posterior to T1 is normal

abnormal rib development ( J:124112 )

• ribs initiate but do not extend on T1 unlike in wild-type mice

decreased rib number ( J:124112 )

• mice are missing a complete first rib

rib fusion ( J:124112 )

• rib 2 and 3 are fused prior to attachment to the sternum

small thoracic cage ( J:124112 )

abnormal intervertebral disk morphology ( J:124112 )

• dorsal cartilage is thickened and forms a distinct curvature at the top of the vertebra unlike in wild-type mice

cervical vertebral fusion ( J:124112 )

vertebral transformation ( J:124112 )

• C3 through T2 exhibit anterior homeotic transformations

• C3 through T1 exhibit characteristics of C2

• however, posterior thoracic, lumbar, and sacral vertebrae are normal in appearance and position

thoracic vertebral transformation ( J:124112 )

• C3 through T1 exhibit characteristics of C2

• T2 lacks anterior projections and is similar to T3

• ibs do not extend on T1 unlike in wild-type mice

cervical vertebral transformation ( J:124112 )

• C3 through T1 exhibit characteristics of C2

• vertebral foramina extend beyond C6 to C7 unlike in wild-type mice

Allelic Composition	Hoxa5^tm1Rob/Hoxa5⁺ Hoxa6^tm1Mrc/Hoxa6⁺ Hoxb5^tm1Mrc/Hoxb5⁺ Hoxb6^tm1Mrc/Hoxb6⁺ Hoxc5^tm1Mrc/Hoxc5⁺ Hoxc6^tm1Dds/Hoxc6⁺
Genetic Background	involves: 129S/SvEv * 129S7/SvEvBrd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxa5^tm1Rob mutation (1 available); any Hoxa5 mutation (28 available)
Hoxa6^tm1Mrc mutation (0 available); any Hoxa6 mutation (9 available)
Hoxb5^tm1Mrc mutation (0 available); any Hoxb5 mutation (11 available)
Hoxb6^tm1Mrc mutation (0 available); any Hoxb6 mutation (14 available)
Hoxc5^tm1Mrc mutation (0 available); any Hoxc5 mutation (12 available)
Hoxc6^tm1Dds mutation (0 available); any Hoxc6 mutation (11 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

abnormal skeleton morphology ( J:124112 )

• primaxial and abaxial skeleton defects are less severe than in either triple homozygote

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