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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gna11tm1Soff
targeted mutation 1, Stefan Offermanns
MGI:2151589
Summary 17 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Gna11tm1Soff/Gna11tm1Soff involves: 129S7/SvEvBrd MGI:2661793
hm2
 		Gna11tm1Soff/Gna11tm1Soff involves: 129S7/SvEvBrd * C57BL/6 MGI:3796548
cn3
 		Cd19tm1(cre)Cgn/Cd19+
Gna11tm1Soff/Gna11tm1Soff
Gnaqtm2Soff/Gnaqtm2Soff 		B6N.129-Cd19tm1(cre)Cgn Gna11tm1Soff Gnaqtm2Soff MGI:3699321
cn4
 		Gna11tm1Soff/Gna11tm1Soff
Gnaqtm2Soff/Gnaqtm2Soff
Tg(Tek-icre/ERT2)1Soff/0 		B6N.Cg-Gna11tm1Soff Gnaqtm2Soff Tg(Tek-icre/ERT2)1Soff MGI:5800455
cn5
 		Gna11tm1Soff/Gna11tm1Soff
Gnaqtm2Soff/Gnaqtm2Soff
Myl2tm1(cre)Krc/Myl2+ 		involves: 129P2/OlaHsd * 129S4/SvJae * 129S7/SvEvBrd * C57BL MGI:3706996
cn6
 		Gna11tm1Soff/Gna11tm1Soff
Gnaqtm2Soff/Gnaqtm2Soff
Tg(PTH-cre)4167Slib/0 		involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 MGI:3796551
cn7
 		Gna11tm1Soff/Gna11tm1Soff
Gnaqtm2Soff/Gnaqtm2Soff
Tg(Mpz-cre)94Imeg/0 		involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 MGI:3796532
cn8
 		Gna11tm1Soff/Gna11+
Gnaqtm2Soff/Gnaqtm2Soff
Tg(PTH-cre)4167Slib/0 		involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 MGI:3796552
cn9
 		Gna11tm1Soff/Gna11tm1Soff
Gnaqtm2Soff/Gnaq+
Tg(PTH-cre)4167Slib/0 		involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 MGI:3796553
cn10
 		Gna11tm1Soff/Gna11tm1Soff
Gnaqtm2Soff/Gnaqtm2Soff
Tg(Tg-cre)1Soff/0 		involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 MGI:3796562
cn11
 		Gna11tm1Soff/Gna11tm1Soff
Gnaqtm2Soff/Gnaqtm2Soff
Tg(Camk2a-cre)1Gsc/0 		involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * FVB/N MGI:3796547
cn12
 		Gna11tm1Soff/Gna11tm1Soff
Gnaqtm2Soff/Gnaqtm2Soff
Tg(Tek-icre/ERT2)1Soff/? 		involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB/N MGI:3837458
cn13
 		Gna11tm1Soff/Gna11tm1Soff
Gnaqtm2Soff/Gnaqtm2Soff
X/Tg(Myh11-icre/ERT2)1Soff 		involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB/N MGI:3819271
cx14
 		Gna11tm1Soff/Gna11tm1Soff
Gnaqtm1Soff/Gnaqtm1Soff 		involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6 MGI:2661813
cx15
 		Gna11tm1Soff/Gna11+
Gnaqtm1Soff/Gnaqtm1Soff 		involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6 MGI:3037556
cx16
 		Gna11tm1Soff/Gna11+
Gnaqtm1Soff/Gnaq+ 		involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6 MGI:3037554
cx17
 		Gna11tm1Soff/Gna11tm1Soff
Gnaqtm1Soff/Gnaq+ 		involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6 MGI:3037555


Genotype
MGI:2661793
hm1
Allelic
Composition		 Gna11tm1Soff/Gna11tm1Soff
Genetic
Background		 involves: 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gna11tm1Soff mutation (0 available); any Gna11 mutation (25 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
increased circulating triglyceride level ( J:172091 )
• on a high-fat, high-sucrose diet
increased liver triglyceride level ( J:172091 )
• on a high-fat, high-sucrose diet

immune system
decreased susceptibility to type I hypersensitivity reaction ( J:146132 )
• mice have a 20% survival rate in an active systemic anaphylaxis model compared to no survival for wild-type controls

nervous system
nervous system phenotype ( J:70180 )
N
• mice do not exhibit defects in brain architechture, synaptic transmission, LTP or LTD

liver/biliary system
increased liver triglyceride level ( J:172091 )
• on a high-fat, high-sucrose diet
hepatic steatosis ( J:172091 )
• on a high-fat, high-sucrose diet




Genotype
MGI:3796548
hm2
Allelic
Composition		 Gna11tm1Soff/Gna11tm1Soff
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gna11tm1Soff mutation (0 available); any Gna11 mutation (25 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:126972 )
N
• modulation of sIAHP in hippocampus are not significantly different from wild-type responses to muscarinic and glutamate receptor agonists




Genotype
MGI:3699321
cn3
Allelic
Composition		 Cd19tm1(cre)Cgn/Cd19+
Gna11tm1Soff/Gna11tm1Soff
Gnaqtm2Soff/Gnaqtm2Soff
Genetic
Background		 B6N.129-Cd19tm1(cre)Cgn Gna11tm1Soff Gnaqtm2Soff
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19tm1(cre)Cgn mutation (11 available); any Cd19 mutation (60 available)
Gna11tm1Soff mutation (0 available); any Gna11 mutation (25 available)
Gnaqtm2Soff mutation (0 available); any Gnaq mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
hematopoietic system phenotype ( J:117663 )
N
• double deficient B cells do not show abnormalities is lysophospholipid-induced adhesion




Genotype
MGI:5800455
cn4
Allelic
Composition		 Gna11tm1Soff/Gna11tm1Soff
Gnaqtm2Soff/Gnaqtm2Soff
Tg(Tek-icre/ERT2)1Soff/0
Genetic
Background		 B6N.Cg-Gna11tm1Soff Gnaqtm2Soff Tg(Tek-icre/ERT2)1Soff
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gna11tm1Soff mutation (0 available); any Gna11 mutation (25 available)
Gnaqtm2Soff mutation (0 available); any Gnaq mutation (24 available)
Tg(Tek-icre/ERT2)1Soff mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
increased susceptibility to hypertension ( J:224523 )
• in response to tamoxifen
decreased vasodilation ( J:224523 )
• almost complete lost of dilation in response to flow
• inhibited acethylcholine-induced vasodilation
• however, vasodilation in response to sodium nitroprusside and vasoconstriction in response to phenylephrine are normal
abnormal vascular wound healing ( J:224523 )
• in response to ligation of the external carotid artery, mice exhibit a strong reduction in neointima formation compared with control mice
• however, there is no change in the diameter of the common carotid artery

homeostasis/metabolism
abnormal vascular wound healing ( J:224523 )
• in response to ligation of the external carotid artery, mice exhibit a strong reduction in neointima formation compared with control mice
• however, there is no change in the diameter of the common carotid artery
decreased nitrate level ( J:224523 )
• decreased in the plasma of tamoxifen-treated mice

muscle
decreased vasodilation ( J:224523 )
• almost complete lost of dilation in response to flow
• inhibited acethylcholine-induced vasodilation
• however, vasodilation in response to sodium nitroprusside and vasoconstriction in response to phenylephrine are normal




Genotype
MGI:3706996
cn5
Allelic
Composition		 Gna11tm1Soff/Gna11tm1Soff
Gnaqtm2Soff/Gnaqtm2Soff
Myl2tm1(cre)Krc/Myl2+
Genetic
Background		 involves: 129P2/OlaHsd * 129S4/SvJae * 129S7/SvEvBrd * C57BL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gna11tm1Soff mutation (0 available); any Gna11 mutation (25 available)
Gnaqtm2Soff mutation (0 available); any Gnaq mutation (24 available)
Myl2tm1(cre)Krc mutation (2 available); any Myl2 mutation (22 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
perinatal lethality, incomplete penetrance ( J:77461 )
• about 75% die perinatally

cardiovascular system
heart hypoplasia ( J:77461 )
• pups that die perinatally exhibit varying degrees of myocardial hypoplasia
• however, mutants that survive to adulthood, appear normal and are fertile
decreased response of heart to induced stress ( J:77461 )
• homozygotes surviving to adulthood exhibit no ventricular hypertrophy in response to pressure-overload induced by aortic constriction, indicating a complete lack of a hypertrophic response

homeostasis/metabolism
decreased response of heart to induced stress ( J:77461 )
• homozygotes surviving to adulthood exhibit no ventricular hypertrophy in response to pressure-overload induced by aortic constriction, indicating a complete lack of a hypertrophic response




Genotype
MGI:3796551
cn6
Allelic
Composition		 Gna11tm1Soff/Gna11tm1Soff
Gnaqtm2Soff/Gnaqtm2Soff
Tg(PTH-cre)4167Slib/0
Genetic
Background		 involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gna11tm1Soff mutation (0 available); any Gna11 mutation (25 available)
Gnaqtm2Soff mutation (0 available); any Gnaq mutation (24 available)
Tg(PTH-cre)4167Slib mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

growth/size/body
short snout ( J:116986 )
• anterior-posterior shortening of craniofacial complex is most pronounced in the snout
decreased body weight ( J:116986 )
• drastically reduced P9 compared to controls
decreased body length ( J:116986 )
• drastically reduced P9 compared to controls
proportional dwarf ( J:116986 )
• severe dwarfism by P9
postnatal growth retardation ( J:116986 )
• internal organs are reduced in size according to general growth retardation of mutants

craniofacial
wide cranial sutures ( J:116986 )
• sutures are much wider than in controls
domed cranium ( J:116986 )
• doming of cranial vault is observed at P9
short snout ( J:116986 )
• anterior-posterior shortening of craniofacial complex is most pronounced in the snout

skeleton
wide cranial sutures ( J:116986 )
• sutures are much wider than in controls
domed cranium ( J:116986 )
• doming of cranial vault is observed at P9
rachitic rosary ( J:116986 )
• bulging of costochondral junction (rachitic rosary) is observed in ribs
decreased bone mineral density ( J:116986 )
• severe osteopenia is observed throughout the skeleton
abnormal epiphyseal plate morphology ( J:116986 )
• all growth plates display rachitic changes
abnormal bone mineralization ( J:116986 )
• barely detectable in bones of paws and caudal vertebrae at P9
• mineralization of ventral ribs is lacking
delayed endochondral bone ossification ( J:116986 )
• noted in cervical and caudal vertebrae, bones of paws, and all long bones
• epiphyseal ossification of femur and tibia is lacking at P9
increased bone resorption ( J:116986 )
• evidence of bone resorption is observed in mutants at P9

endocrine/exocrine glands
abnormal parathyroid gland morphology ( J:116986 )
• proliferation of cells is significantly enhance compared to controls
small thyroid gland ( J:116986 )
• massively growth-retarded

homeostasis/metabolism
increased circulating parathyroid hormone level ( J:116986 )
• significantly increased levels are observed at P9
increased urine calcium level ( J:116986 )
• urine calcium level is strongly increased

renal/urinary system
increased urine calcium level ( J:116986 )
• urine calcium level is strongly increased

respiratory system
abnormal larynx morphology ( J:116986 )
• massively growth-retarded




Genotype
MGI:3796532
cn7
Allelic
Composition		 Gna11tm1Soff/Gna11tm1Soff
Gnaqtm2Soff/Gnaqtm2Soff
Tg(Mpz-cre)94Imeg/0
Genetic
Background		 involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gna11tm1Soff mutation (0 available); any Gna11 mutation (25 available)
Gnaqtm2Soff mutation (0 available); any Gnaq mutation (24 available)
Tg(Mpz-cre)94Imeg mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
craniofacial
craniofacial phenotype ( J:131382 )
N
• incisive alveolar bone in distal mandibular region is relatively well-developed
abnormal alisphenoid bone morphology ( J:131382 )
• lamina obturans is duplicated
abnormal pterygoid process morphology ( J:131382 )
• duplicated in mutants
abnormal hyoid bone morphology ( J:131382 )
• hyoid is not fused to basisphenoid in all cases; body of hyoid has extended ossification center and is fused to lesser hyoid horn and often with superior horn of thyroid similar to Ednrb-knock-in homozygotes
lower jaw to upper jaw transformation ( J:131382 )
• maxillary bones are duplicated in mandibular region
abnormal palatine bone morphology ( J:131382 )
• duplication of palatine bone is observed
abnormal zygomatic bone morphology ( J:131382 )
• duplication of jugal bone in mandibular region is observed

skeleton
abnormal alisphenoid bone morphology ( J:131382 )
• lamina obturans is duplicated
abnormal pterygoid process morphology ( J:131382 )
• duplicated in mutants
abnormal hyoid bone morphology ( J:131382 )
• hyoid is not fused to basisphenoid in all cases; body of hyoid has extended ossification center and is fused to lesser hyoid horn and often with superior horn of thyroid similar to Ednrb-knock-in homozygotes
lower jaw to upper jaw transformation ( J:131382 )
• maxillary bones are duplicated in mandibular region
abnormal palatine bone morphology ( J:131382 )
• duplication of palatine bone is observed
abnormal zygomatic bone morphology ( J:131382 )
• duplication of jugal bone in mandibular region is observed




Genotype
MGI:3796552
cn8
Allelic
Composition		 Gna11tm1Soff/Gna11+
Gnaqtm2Soff/Gnaqtm2Soff
Tg(PTH-cre)4167Slib/0
Genetic
Background		 involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gna11tm1Soff mutation (0 available); any Gna11 mutation (25 available)
Gnaqtm2Soff mutation (0 available); any Gnaq mutation (24 available)
Tg(PTH-cre)4167Slib mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
decreased body weight ( J:116986 )
• reduced at P9 compared to controls

homeostasis/metabolism
increased circulating parathyroid hormone level ( J:116986 )
• levels are increased compared to controls at P9
abnormal circulating calcium level ( J:116986 )
• increased relative to controls
abnormal urine calcium level ( J:116986 )
• increased relative to controls at P9

renal/urinary system
abnormal urine calcium level ( J:116986 )
• increased relative to controls at P9




Genotype
MGI:3796553
cn9
Allelic
Composition		 Gna11tm1Soff/Gna11tm1Soff
Gnaqtm2Soff/Gnaq+
Tg(PTH-cre)4167Slib/0
Genetic
Background		 involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gna11tm1Soff mutation (0 available); any Gna11 mutation (25 available)
Gnaqtm2Soff mutation (0 available); any Gnaq mutation (24 available)
Tg(PTH-cre)4167Slib mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
decreased body weight ( J:116986 )
• reduced at P9 compared to controls

homeostasis/metabolism
increased circulating parathyroid hormone level ( J:116986 )
• levels are increased compared to controls
abnormal circulating calcium level ( J:116986 )
• increased relative to controls at P9
abnormal urine calcium level ( J:116986 )
• increased relative to controls

renal/urinary system
abnormal urine calcium level ( J:116986 )
• increased relative to controls




Genotype
MGI:3796562
cn10
Allelic
Composition		 Gna11tm1Soff/Gna11tm1Soff
Gnaqtm2Soff/Gnaqtm2Soff
Tg(Tg-cre)1Soff/0
Genetic
Background		 involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gna11tm1Soff mutation (0 available); any Gna11 mutation (25 available)
Gnaqtm2Soff mutation (0 available); any Gnaq mutation (24 available)
Tg(Tg-cre)1Soff mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
endocrine/exocrine gland phenotype ( J:127484 )
N
• as mutants age, no significant differences in thyroid size or weight is observed relative to wild-type
abnormal thyroid gland morphology ( J:127484 )
• at 6 months of age, histology is altered; follicular structure is disturbed with few normal follicles remaining
• no increase in thyroid gland weight is observed in 6-8 week-old mice treated with TSH (thyroid stimulating hormone) for 1 week, whereas wild-type mice show a 100% increase in thyroid weight; glands in mutants actually decrease in weight due to slight decrease in follicular lumen size
• no increase in thyrocyte number is observed after TSH treatment in contrast to increase seen in wild-type; thryocytes show hypertrophic response to TSH treatment
• after TSH treatment, colloid area is reduced unlike wild-type thyroids
• mutant thyroids show no response to goitrogenic diet, whereas wild-type mice readily develop hyperplastic goiters
abnormal thyroid follicular cell morphology ( J:127484 )
• cells are often enlarged, columnar and have large nuclei at 6 months of age
abnormal thyroid gland physiology ( J:127484 )
• TSH-induced thyroid hormone release is almost entirely abrogated in mutants
• impaired pinocytic uptake of colloid and reduction in pinocytic vesicle formation in thyroid follicular epithelium upon TSH stimulation is observed in mutants versus wild-type
decreased activity of thyroid gland ( J:127484 )
• after 6 months of age, about half of animals display overt hypothyroidism

homeostasis/metabolism
decreased circulating thyroxine level ( J:127484 )
• at 6 months, mice show low T4 levels compared to wild-type
increased circulating thyroid-stimulating hormone level ( J:127484 )
• beginning at 2 months of age, TSH (thyroid stimulating hormone) plasma levels start to rise and are significantly higher than wild-type at 6 months of age




Genotype
MGI:3796547
cn11
Allelic
Composition		 Gna11tm1Soff/Gna11tm1Soff
Gnaqtm2Soff/Gnaqtm2Soff
Tg(Camk2a-cre)1Gsc/0
Genetic
Background		 involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gna11tm1Soff mutation (0 available); any Gna11 mutation (25 available)
Gnaqtm2Soff mutation (0 available); any Gnaq mutation (24 available)
Tg(Camk2a-cre)1Gsc mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:111559 )
• age-dependent reduction in survival due to tonic-clonic seizures

nervous system
seizures ( J:111559 )
• around 3 months of age, mice show spontaneous epileptic seizures; animals affected and seizure number per animal increase with age
• mutants show reduced latency to seizure onset and tendency to have stronger seizures when treated with kainic acid or PTZ than wild-type; seizure-induced lethality is greatly increased
• blockade of cannabinoid receptors does not result in aggravation of kainic acid-induced seizures in mutants but does in wild-type controls
• treatment of mutants with endocannabinoid reuptake inhibitor causes a significant amelioration of kainic acid induced seizures
clonic seizures ( J:111559 )
• most seizures are myoclonic
tonic-clonic seizures ( J:111559 )
• some animals exhibit tonic-clonic seizures with age
hippocampal neuron degeneration ( J:111559 )
• older animals particularly those with symptomatic epilepsy show neuronal degeneration in CA1 region
gliosis ( J:111559 )
• older mice display reactive gliosis in CA1 region of hippocampus
abnormal nervous system electrophysiology ( J:123222 )
• no CCK4-induced (cholecystokinin receptor2 agonist) current is detected in amygdala slices while inward current response in wild-type is unaffected

behavior/neurological
seizures ( J:111559 )
• around 3 months of age, mice show spontaneous epileptic seizures; animals affected and seizure number per animal increase with age
• mutants show reduced latency to seizure onset and tendency to have stronger seizures when treated with kainic acid or PTZ than wild-type; seizure-induced lethality is greatly increased
• blockade of cannabinoid receptors does not result in aggravation of kainic acid-induced seizures in mutants but does in wild-type controls
• treatment of mutants with endocannabinoid reuptake inhibitor causes a significant amelioration of kainic acid induced seizures
clonic seizures ( J:111559 )
• most seizures are myoclonic
tonic-clonic seizures ( J:111559 )
• some animals exhibit tonic-clonic seizures with age




Genotype
MGI:3837458
cn12
Allelic
Composition		 Gna11tm1Soff/Gna11tm1Soff
Gnaqtm2Soff/Gnaqtm2Soff
Tg(Tek-icre/ERT2)1Soff/?
Genetic
Background		 involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gna11tm1Soff mutation (0 available); any Gna11 mutation (25 available)
Gnaqtm2Soff mutation (0 available); any Gnaq mutation (24 available)
Tg(Tek-icre/ERT2)1Soff mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
decreased vascular permeability ( J:146132 )
• in mice with induction of cre recombinase, basal permeability is lower than controls
• vascular permeability does not increase above basal levels in response to histamine, IgE, platelet-activating factor (PAF), lysophosphatidic acid (LPA), or F2r-activating peptide
• mice are resistant to death resulting from PAF-induced shock

immune system
immune system phenotype ( J:146132 )
N
• while resistant to shock induced by IgE or vasoactive substances, mice are not resistant to shock induced by LPS
decreased susceptibility to type I hypersensitivity reaction ( J:146132 )
• tamoxifen treated mice are resistant to IgE-induced anaphylactic shock
• in an anti-DNP model, mice only have transient drops in systolic blood pressure compared to the sustained (>90 min) drops that occur in controls
• in an anti-BSA model, all mice survive anaphylactic challenge with only moderate decreases in body temperature compared to controls that suffer from severe hypothermia and death within 20 min of challenge




Genotype
MGI:3819271
cn13
Allelic
Composition		 Gna11tm1Soff/Gna11tm1Soff
Gnaqtm2Soff/Gnaqtm2Soff
X/Tg(Myh11-icre/ERT2)1Soff
Genetic
Background		 involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gna11tm1Soff mutation (0 available); any Gna11 mutation (25 available)
Gnaqtm2Soff mutation (0 available); any Gnaq mutation (24 available)
Tg(Myh11-icre/ERT2)1Soff mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
decreased systemic arterial blood pressure ( J:141641 )
• tamoxifen-treated mice exhibit decreased blood pressure following treatment with angiotensin II, vasopressin and endothelin compared to in wild-type mice
• tamoxifen-treated mice exposed to DOCA-salt do not develop hypertension and DOCA-salt treated mice exposed to tamoxifen following the onset of hypertension exhibit a drop in blood pressure compared to in similarly treated wild-type mice
decreased mean systemic arterial blood pressure ( J:141641 )
• following a normal transient increase in mean arterial blood pressure upon treatment with tamoxifen, mice exhibit a drop in mean arterial blood pressure below normal levels
• slight in the absence of tamoxifen induction
decreased vasoconstriction ( J:141641 )
• tamoxifen-treated mice fail to exhibit vasocontractile effects induced by phenylephrine or angiotensin II as do wild-type mice
• tamoxifen-treated mice exhibit reduced vasocontraction in response to serotonine, vasopressin, U46619 and endothelin-1 compared to similarly treated wild-type mice

muscle
decreased vasoconstriction ( J:141641 )
• tamoxifen-treated mice fail to exhibit vasocontractile effects induced by phenylephrine or angiotensin II as do wild-type mice
• tamoxifen-treated mice exhibit reduced vasocontraction in response to serotonine, vasopressin, U46619 and endothelin-1 compared to similarly treated wild-type mice




Genotype
MGI:2661813
cx14
Allelic
Composition		 Gna11tm1Soff/Gna11tm1Soff
Gnaqtm1Soff/Gnaqtm1Soff
Genetic
Background		 involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gna11tm1Soff mutation (0 available); any Gna11 mutation (25 available)
Gnaqtm1Soff mutation (1 available); any Gnaq mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality during organogenesis, complete penetrance ( J:49140 )
• mutant embryos appear normal ar E9.5, growth arrests prior to E10.5 and die by E11

cardiovascular system
trabecula carnea hypoplasia ( J:49140 )
• apparent by E9.5; underdeveloped trabecular ventricular myocardium
ventricular myocardium compact layer hypoplasia ( J:49140 )
• apparent by E9.5; underdeveloped subepicardial layer
hemopericardium ( J:49140 )
• enlarged heart due to bleeding into the space between the myocardial and pericardial layers

homeostasis/metabolism
hemopericardium ( J:49140 )
• enlarged heart due to bleeding into the space between the myocardial and pericardial layers

muscle
trabecula carnea hypoplasia ( J:49140 )
• apparent by E9.5; underdeveloped trabecular ventricular myocardium
ventricular myocardium compact layer hypoplasia ( J:49140 )
• apparent by E9.5; underdeveloped subepicardial layer




Genotype
MGI:3037556
cx15
Allelic
Composition		 Gna11tm1Soff/Gna11+
Gnaqtm1Soff/Gnaqtm1Soff
Genetic
Background		 involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gna11tm1Soff mutation (0 available); any Gna11 mutation (25 available)
Gnaqtm1Soff mutation (1 available); any Gnaq mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
neonatal lethality, complete penetrance ( J:49140 )
• animals die within 1-2 hours after birth

behavior/neurological
hyporesponsive to tactile stimuli ( J:49140 )
• poorly responsive to tactile stimuli

cardiovascular system
common ventricle ( J:49140 )
• high incidence of univentricular hearts

craniofacial
incus hypoplasia ( J:49140 )
• poorly developed incus
malleus hypoplasia ( J:49140 )
• poorly developed malleus
stapes hypoplasia ( J:49140 )
• poorly developed stapes

growth/size/body
decreased body size ( J:49140 )
• animals appear runted at birth

hearing/vestibular/ear
incus hypoplasia ( J:49140 )
• poorly developed incus
malleus hypoplasia ( J:49140 )
• poorly developed malleus
stapes hypoplasia ( J:49140 )
• poorly developed stapes
abnormal tympanic ring morphology ( J:49140 )
• vestigial tympanic ring

respiratory system
abnormal breathing pattern ( J:49140 )
• arrhythmic breathing
decreased pulmonary respiratory rate ( J:49140 )
• animals breathed at approximately half the rate of controls

skeleton
incus hypoplasia ( J:49140 )
• poorly developed incus
malleus hypoplasia ( J:49140 )
• poorly developed malleus
stapes hypoplasia ( J:49140 )
• poorly developed stapes

homeostasis/metabolism
hypoxia ( J:49140 )
• noted at birth




Genotype
MGI:3037554
cx16
Allelic
Composition		 Gna11tm1Soff/Gna11+
Gnaqtm1Soff/Gnaq+
Genetic
Background		 involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gna11tm1Soff mutation (0 available); any Gna11 mutation (25 available)
Gnaqtm1Soff mutation (1 available); any Gnaq mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:49140 )
• mice are viable and fertile




Genotype
MGI:3037555
cx17
Allelic
Composition		 Gna11tm1Soff/Gna11tm1Soff
Gnaqtm1Soff/Gnaq+
Genetic
Background		 involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gna11tm1Soff mutation (0 available); any Gna11 mutation (25 available)
Gnaqtm1Soff mutation (1 available); any Gnaq mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
neonatal lethality, complete penetrance ( J:49140 )
• animals die within 1-2 hours after birth

behavior/neurological
hyporesponsive to tactile stimuli ( J:49140 )
• poorly responsive to tactile stiluli

cardiovascular system
abnormal heart size ( J:49140 )
• hearts are described as malformed, either hypertrophic or hypotrophic

growth/size/body
decreased body size ( J:49140 )
• animals appear runted at birth

respiratory system
abnormal breathing pattern ( J:49140 )
• arrythmic breathing
decreased pulmonary respiratory rate ( J:49140 )
• animals breathed at approximately half the rate of controls

homeostasis/metabolism
hypoxia ( J:49140 )
• apparent at birth




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory