Phenotypes associated with this allele

• Allele Symbol: Hoxb1^tm1Brd
• Allele Name: targeted mutation 1, Allan Bradley
• Allele ID: MGI:2151762
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hoxb1^tm1Brd/Hoxb1^tm1Brd	involves: 129S7/SvEvBrd * C57BL/6	MGI:2675275

Genotype
MGI:2675275

hm1

• Allelic Composition: Hoxb1^tm1Brd/Hoxb1^tm1Brd
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, incomplete penetrance ( J:37450 )

• 98% of mice die at birth

nervous system

abnormal neuron differentiation ( J:37450 )

• at E10.5 to E11.5, the facial branchiomotor neurons and contralateral vestibularacoustic efferent neurons are incorrectly specified

abnormal axon guidance ( J:37450 )

• visceromotor neurons exhibit abnormal axonal trajectories

abnormal rhombomere 4 morphology ( J:37450 )

• the identity of r4 is properly established but not properly maintained as determined by marker expression

abnormal facial nerve morphology ( J:37450 )

• at E10.5 to E11.5, the facial branchiomotor neurons and contralateral vestibularacoustic efferent neurons are absent

• visceromotor neurons exhibit abnormal axonal trajectories

embryo

abnormal rhombomere 4 morphology ( J:37450 )

• the identity of r4 is properly established but not properly maintained as determined by marker expression

cellular

abnormal neuron differentiation ( J:37450 )

• at E10.5 to E11.5, the facial branchiomotor neurons and contralateral vestibularacoustic efferent neurons are incorrectly specified

abnormal axon guidance ( J:37450 )

• visceromotor neurons exhibit abnormal axonal trajectories