About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Hoxb3tm1Mrc
targeted mutation 1, Mario R Capecchi
MGI:2151773
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Hoxb3tm1Mrc/Hoxb3tm1Mrc involves: 129S4/SvJae * C57BL/6 MGI:2675269
cx2
 		Hoxa3tm3Mrc/Hoxa3tm3Mrc
Hoxb3tm1Mrc/Hoxb3tm1Mrc 		involves: 129S4/SvJae MGI:3836912
cx3
 		Hoxa3tm1Mrc/Hoxa3tm1Mrc
Hoxb3tm1Mrc/Hoxb3tm1Mrc 		involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6J MGI:3038610
cx4
 		Hoxa3tm1Mrc/Hoxa3+
Hoxb3tm1Mrc/Hoxb3tm1Mrc 		involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6J MGI:3611934
cx5
 		Hoxb3tm1Mrc/Hoxb3tm1Mrc
Hoxd3tm1Mrc/Hoxd3tm1Mrc 		involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6J MGI:3611935


Genotype
MGI:2675269
hm1
Allelic
Composition		 Hoxb3tm1Mrc/Hoxb3tm1Mrc
Genetic
Background		 involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxb3tm1Mrc mutation (0 available); any Hoxb3 mutation (16 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
neonatal lethality, incomplete penetrance ( J:45337 )
• a small number of newborns are found dead soon after birth, consistent with the low frequency of the IXth cranial nerve defects

skeleton
fusion of atlas and odontoid process ( J:45337 )
• the anterior arch of the atlas is joined by an ossified bridge to the dens of the axis, low penetrance

nervous system
fusion of glossopharyngeal and vagus nerve ( J:45337 )
• partial deletion of cranial nerve IX or fusion to cranial nerve X at relatively low penetrance




Genotype
MGI:3836912
cx2
Allelic
Composition		 Hoxa3tm3Mrc/Hoxa3tm3Mrc
Hoxb3tm1Mrc/Hoxb3tm1Mrc
Genetic
Background		 involves: 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxa3tm3Mrc mutation (0 available); any Hoxa3 mutation (24 available)
Hoxb3tm1Mrc mutation (0 available); any Hoxb3 mutation (16 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal somatic motor system morphology ( J:86041 )
• incomplete loss of somatic motor neurons restricted to r5
• possibly involving a "change of fate" to V2 interneurons




Genotype
MGI:3038610
cx3
Allelic
Composition		 Hoxa3tm1Mrc/Hoxa3tm1Mrc
Hoxb3tm1Mrc/Hoxb3tm1Mrc
Genetic
Background		 involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxa3tm1Mrc mutation (0 available); any Hoxa3 mutation (24 available)
Hoxb3tm1Mrc mutation (0 available); any Hoxb3 mutation (16 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
neonatal lethality, complete penetrance ( J:45337 )
• died within hours of birth

skeleton
abnormal supraoccipital bone morphology ( J:45337 )
• defective formation, 100% penetrance
abnormal hyoid bone greater horn morphology ( J:45337 )
• the greater horn is almost entirely missing
abnormal hyoid bone lesser horn morphology ( J:45337 )
• progressive loss of lesser horn
abnormal cricoid cartilage morphology ( J:45337 )
• small and sometimes fused to thyroid cartilage
thyroid cartilage hypoplasia ( J:45337 )
• poorly formed
abnormal cervical atlas morphology ( J:45337 )
• reduced neural arch
fusion of atlas and occipital bones ( J:45337 )
• anterior arch of atlas fused to basioccipital bone
abnormal cervical axis morphology ( J:45337 )
• reduced neural arch

endocrine/exocrine glands
abnormal ultimobranchial body morphology ( J:46523 )
• variable development of ultimobranchial bodies, sometimes absent, sometimes persistent in adults
absent ultimobranchial body ( J:46523 )
• sometimes absent
persistent ultimobranchial bodies ( J:46523 )
• sometimes persistent in adults
abnormal thyroid gland isthmus morphology ( J:46523 )
• absent or defective thyroid isthmus

respiratory system
abnormal cricoid cartilage morphology ( J:45337 )
• small and sometimes fused to thyroid cartilage
thyroid cartilage hypoplasia ( J:45337 )
• poorly formed

nervous system
decreased sensory neuron number ( J:88581 )
• absence of noradrenergic visceral sensory interneurons and associated expansion of the somatic sensory interneuron domain in rhombomere 5

craniofacial
abnormal supraoccipital bone morphology ( J:45337 )
• defective formation, 100% penetrance
fusion of atlas and occipital bones ( J:45337 )
• anterior arch of atlas fused to basioccipital bone
abnormal hyoid bone greater horn morphology ( J:45337 )
• the greater horn is almost entirely missing
abnormal hyoid bone lesser horn morphology ( J:45337 )
• progressive loss of lesser horn

embryo
abnormal ultimobranchial body morphology ( J:46523 )
• variable development of ultimobranchial bodies, sometimes absent, sometimes persistent in adults
absent ultimobranchial body ( J:46523 )
• sometimes absent
persistent ultimobranchial bodies ( J:46523 )
• sometimes persistent in adults




Genotype
MGI:3611934
cx4
Allelic
Composition		 Hoxa3tm1Mrc/Hoxa3+
Hoxb3tm1Mrc/Hoxb3tm1Mrc
Genetic
Background		 involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxa3tm1Mrc mutation (0 available); any Hoxa3 mutation (24 available)
Hoxb3tm1Mrc mutation (0 available); any Hoxb3 mutation (16 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
ectopic thymus ( J:46523 )
• lobes of thymus displaced anteriorly

endocrine/exocrine glands
ectopic parathyroid gland ( J:46523 )
• ectopic parathyroids near the anterior ends of the thymus
ectopic thymus ( J:46523 )
• lobes of thymus displaced anteriorly

hematopoietic system
ectopic thymus ( J:46523 )
• lobes of thymus displaced anteriorly




Genotype
MGI:3611935
cx5
Allelic
Composition		 Hoxb3tm1Mrc/Hoxb3tm1Mrc
Hoxd3tm1Mrc/Hoxd3tm1Mrc
Genetic
Background		 involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxb3tm1Mrc mutation (0 available); any Hoxb3 mutation (16 available)
Hoxd3tm1Mrc mutation (0 available); any Hoxd3 mutation (13 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, complete penetrance ( J:45337 )
• all homozygotes dead by the end of the first week after birth
neonatal lethality, incomplete penetrance ( J:45337 )
• about 50% die at birth

skeleton
abnormal hyoid bone morphology ( J:45337 )
• greater horn sometimes fused to thyroid cartilage
hyoid bone hypoplasia ( J:19447 )
• reduced in size
abnormal thyroid cartilage morphology ( J:19447 )
• dorsally associated cartilage of thyroid cartilage is missing
abnormal cervical atlas morphology ( J:19447 )
• neural arch resembles more posterior cervical vertebrae (C3-C5)
absent cervical atlas ( J:19447 )
• atlas missing, with small cartilage remnants

nervous system
fusion of glossopharyngeal and vagus nerve ( J:45337 )
• partial deletion of cranial nerve IX or fusion to cranial nerve X, increased penetrance

endocrine/exocrine glands
abnormal ultimobranchial body morphology ( J:46523 )
• low penetrance of partially fused ultimobranchial bodies

respiratory system
abnormal thyroid cartilage morphology ( J:19447 )
• dorsally associated cartilage of thyroid cartilage is missing

craniofacial
abnormal hyoid bone morphology ( J:45337 )
• greater horn sometimes fused to thyroid cartilage
hyoid bone hypoplasia ( J:19447 )
• reduced in size

embryo
abnormal ultimobranchial body morphology ( J:46523 )
• low penetrance of partially fused ultimobranchial bodies




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory