Phenotypes associated with this allele

• Allele Symbol: Hoxb2^tm1Fmr
• Allele Name: targeted mutation 1, Filippo M Rijli
• Allele ID: MGI:2151774
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hoxb2^tm1Fmr/Hoxb2^tm1Fmr	involves: 129	MGI:3722145
cx2	Hoxa2^tm1Ipc/Hoxa2^tm1Ipc Hoxb2^tm1Fmr/Hoxb2^tm1Fmr	involves: 129/Sv * 129S2/SvPas	MGI:3722142

Genotype
MGI:3722145

hm1

• Allelic Composition: Hoxb2^tm1Fmr/Hoxb2^tm1Fmr
• Genetic Background: involves: 129

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:54652 )

• 22 of the 60 mice that survived to weaning die between 3 weeks and 2 months

neonatal lethality, incomplete penetrance ( J:54652 )

• 82% of mice die around birth

postnatal lethality, incomplete penetrance ( J:54652 )

• only 60 of 1073 mice survive to weaning

nervous system

abnormal rhombomere 4 morphology ( J:54652 )

• r4 exhibits characteristics of r2

rhombomere transformation ( J:54652 )

• r4 exhibits characteristics of r2

absent facial nuclei ( J:54652 )

• at E13.5, facial motor nucleus are absent in 5 of 5 mice

behavior/neurological

abnormal maternal nurturing ( J:54652 )

♀ • females that survive and reproduce have difficulties raising their pups

embryo

abnormal rhombomere 4 morphology ( J:54652 )

• r4 exhibits characteristics of r2

rhombomere transformation ( J:54652 )

• r4 exhibits characteristics of r2

Genotype
MGI:3722142

cx2

• Allelic Composition: Hoxa2^tm1Ipc/Hoxa2^tm1Ipc; Hoxb2^tm1Fmr/Hoxb2^tm1Fmr
• Genetic Background: involves: 129/Sv * 129S2/SvPas

mortality/aging

neonatal lethality, complete penetrance ( J:54652 )

• lethality occurs soon after birth

nervous system

abnormal rhombomere morphology ( J:54652 )

• the r1 to r3 region is altered such that r1 appears posteriorly extended at the expense of r2 and r3

• alterations to r1 through r3 are more severe than in Hoxa2^tm1Ipc homozygotes

increased rhombomere 1 size ( J:54652 )

• r1 appears posteriorly extended at the expense of r2-r3 dorsal domains, resulting in a caudal shift of the pontine flexure

embryo

abnormal rhombomere morphology ( J:54652 )

• the r1 to r3 region is altered such that r1 appears posteriorly extended at the expense of r2 and r3

• alterations to r1 through r3 are more severe than in Hoxa2^tm1Ipc homozygotes

increased rhombomere 1 size ( J:54652 )

• r1 appears posteriorly extended at the expense of r2-r3 dorsal domains, resulting in a caudal shift of the pontine flexure