Phenotypes associated with this allele

• Allele Symbol: Hoxd11^tm1Ipc
• Allele Name: targeted mutation 1, Pierre Chambon
• Allele ID: MGI:2151798
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hoxd11^tm1Ipc/Hoxd11^tm1Ipc	either: (involves: 129/Sv * 129S2/SvPas) or (involves: 129S2/SvPas * C57BL/6)	MGI:3718319
ht2	Hoxd11^tm1Ipc/Hoxd11^tm2Ddu	involves: 129S2/SvPas * C57BL/6J	MGI:3718239
cx3	Del(2Hoxd11-Hoxd13)29Ddu/Del(2Hoxd11-Hoxd13)29Ddu Hoxd11^tm1Ipc/Hoxd11^tm1Ipc	involves: 129S2/SvPas * C57BL/6J	MGI:3718238

Genotype
MGI:3718319

hm1

• Allelic Composition: Hoxd11^tm1Ipc/Hoxd11^tm1Ipc
• Genetic Background: either: (involves: 129/Sv * 129S2/SvPas) or (involves: 129S2/SvPas * C57BL/6)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Anterior homeosis of sacral vertebrae of wild type and Hoxd11^tm1Ipc/Hoxd11^tm1Ipc mice

reproductive system

male infertility ( J:22289 )

♂ • only 3 of 13 males produced one litter each

skeleton

abnormal carpal bone morphology ( J:22289 )

• in 100 of 106 mice the pisiform heard is abnormal

• in 69 of 106 mice the palmar process of the scapholunate is abnormal

• in 46 of 106 mice the scapholunate dorsal aspect has lunate enlargement

• in 28 of 106 mice the sesamoid is absent, 16 of 106 mice the sesamoid is small and in 4 of 106 mice the sesamoid is big

• at E15.5, there is a delay in chondrification in the lunate versus the scaphoid balstema

fused carpal bones ( J:22289 )

• in 24 of 106 mice the scapholunate and pyramidal bones are fused

• in 95 of 106 mice the pyramidal and pisiform bones are fused

abnormal phalanx morphology ( J:22289 )

• the phalanx of digit II is slightly smaller than in wild-type mice

abnormal radius morphology ( J:22289 )

• in 40 of 106 mice the palmar side of the radial epiphysis is flattened

• in 39 of 106 mice the gap between the radius and the ulna is enlarged

abnormal ulna morphology ( J:22289 )

• in 85 of 106 mice the stylus process of the ulna is smaller

• in 39 of 106 mice the gap between the radius and the ulna is enlarged

short metacarpal bones ( J:22289 )

• in 96 of 106 mice metacarpal bones II, III and IV are shortened by 10% 3 days after birth and by 30% in adults

abnormal ilium morphology ( J:22289 )

• in some mice the ilium articulates to one vertebrae more posterior than in normal sacral vertebrae

• in 4 mice, the ilia is articulated to 2 distinct vertebrae (S0 on the right and S1 on the left)

increased presacral vertebrae number ( J:22289 )

• some mice have an addition (S0) sacral vertebrae which appears as an intermediate vertebrae

increased lumbar vertebrae number ( J:22289 )

• 38% of mice have an additional lumbar vertebrae

abnormal sacral vertebrae morphology ( J:22289 )

• some mice have an intermediate sacral vertebrae with transverse processes that are not tightly joined to the ilium and smaller than normal for the first sacral transverse processes

• in 4 mice the S0 vertebrae is asymmetric with a lumbar like transverse process on the left side and first sacral-like transverse processes on the right side and the ilia is articulated to 2 distinct vertebrae (S0 on the right and S1 on the left)in 4 mice the S0 vertebrae is asymmetric with a lumbar like transverse process on the left side and first sacral-like transverse processes on the right side and the ilia is articulated to 2 distinct vertebrae (S0 on the right and S1 on the left)

• S0 and S1 exhibit an anterior transformation

sacral vertebral transformation ( J:22289 )

• S0 and S1 exhibit asymmetric anterior transformation

limbs/digits/tail

abnormal carpal bone morphology ( J:22289 )

• in 46 of 106 mice the scapholunate dorsal aspect has lunate enlargement

• in 100 of 106 mice the pisiform heard is abnormal

• in 69 of 106 mice the palmar process of the scapholunate is abnormal

• in 28 of 106 mice the sesamoid is absent, 16 of 106 mice the sesamoid is small and in 4 of 106 mice the sesamoid is big

• at E15.5, there is a delay in chondrification in the lunate versus the scaphoid balstema

fused carpal bones ( J:22289 )

• in 24 of 106 mice the scapholunate and pyramidal bones are fused

• in 95 of 106 mice the pyramidal and pisiform bones are fused

abnormal phalanx morphology ( J:22289 )

• the phalanx of digit II is slightly smaller than in wild-type mice

abnormal radius morphology ( J:22289 )

• in 40 of 106 mice the palmar side of the radial epiphysis is flattened

• in 39 of 106 mice the gap between the radius and the ulna is enlarged

abnormal ulna morphology ( J:22289 )

• in 85 of 106 mice the stylus process of the ulna is smaller

• in 39 of 106 mice the gap between the radius and the ulna is enlarged

short metacarpal bones ( J:22289 )

• in 96 of 106 mice metacarpal bones II, III and IV are shortened by 10% 3 days after birth and by 30% in adults

Genotype
MGI:3718239

ht2

• Allelic Composition: Hoxd11^tm1Ipc/Hoxd11^tm2Ddu
• Genetic Background: involves: 129S2/SvPas * C57BL/6J

skeleton

abnormal carpal bone morphology ( J:41828 )

• 7 of 7 mice have carpal bone defects

• cartilage and ossification centers between the pyramidal and navicular-lunate are partially fused

abnormal lumbar vertebrae morphology ( J:41828 )

• 3 of 7 mice have an abnormal L6

increased lumbar vertebrae number ( J:41828 )

• 2 of 7 mice showed an L7 formula instead of an L6 formula found in wild-type mice

limbs/digits/tail

abnormal carpal bone morphology ( J:41828 )

• 7 of 7 mice have carpal bone defects

• cartilage and ossification centers between the pyramidal and navicular-lunate are partially fused

Genotype
MGI:3718238

cx3

• Allelic Composition: Del(2Hoxd11-Hoxd13)29Ddu/Del(2Hoxd11-Hoxd13)29Ddu; Hoxd11^tm1Ipc/Hoxd11^tm1Ipc
• Genetic Background: involves: 129S2/SvPas * C57BL/6J

skeleton

abnormal carpal bone morphology ( J:41828 )

• 3 of 3 mice have carpal bone defects

fused carpal bones ( J:41828 )

• proximal carpal elements are fused in some mice

abnormal lumbar vertebrae morphology ( J:41828 )

• 3 of 3 mice have abnormal L4

increased lumbar vertebrae number ( J:41828 )

• 3 of 3 mice have abnormal L7 formula instead of an L6 formula found in wild-type mice

limbs/digits/tail

abnormal carpal bone morphology ( J:41828 )

• 3 of 3 mice have carpal bone defects

fused carpal bones ( J:41828 )

• proximal carpal elements are fused in some mice

abnormal digit morphology ( J:41828 )

• the second phalanges of digits II and V is completely lost

• other digits have phalanges defects