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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Msh3tm1Htr
targeted mutation 1, Hein te Riele
MGI:2151802
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Msh3tm1Htr/Msh3tm1Htr involves: 129P2/OlaHsd * FVB/N MGI:3851206
cx2
Msh3tm1Htr/Msh3tm1Htr
Msh6tm1Htr/Msh6tm1Htr
involves: 129P2/OlaHsd * FVB/N MGI:3851208


Genotype
MGI:3851206
hm1
Allelic
Composition
Msh3tm1Htr/Msh3tm1Htr
Genetic
Background
involves: 129P2/OlaHsd * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Msh3tm1Htr mutation (0 available); any Msh3 mutation (61 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
N
• mice are not predisposed to cancer




Genotype
MGI:3851208
cx2
Allelic
Composition
Msh3tm1Htr/Msh3tm1Htr
Msh6tm1Htr/Msh6tm1Htr
Genetic
Background
involves: 129P2/OlaHsd * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Msh3tm1Htr mutation (0 available); any Msh3 mutation (61 available)
Msh6tm1Htr mutation (0 available); any Msh6 mutation (52 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice exhibit premature lethality due to tumor development

neoplasm
• 8 of 13 mice develop intestinal tumors
• 3 of 13 mice develop epithelial cancer of the skin
• in 9 of 13 mice

digestive/alimentary system
• 8 of 13 mice develop intestinal tumors

integument
• 3 of 13 mice develop epithelial cancer of the skin





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory