About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Msh3tm1Htr
targeted mutation 1, Hein te Riele
MGI:2151802
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Msh3tm1Htr/Msh3tm1Htr involves: 129P2/OlaHsd * FVB/N MGI:3851206
cx2
Msh3tm1Htr/Msh3tm1Htr
Msh6tm1Htr/Msh6tm1Htr
involves: 129P2/OlaHsd * FVB/N MGI:3851208


Genotype
MGI:3851206
hm1
Allelic
Composition
Msh3tm1Htr/Msh3tm1Htr
Genetic
Background
involves: 129P2/OlaHsd * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Msh3tm1Htr mutation (0 available); any Msh3 mutation (61 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
N
• mice are not predisposed to cancer




Genotype
MGI:3851208
cx2
Allelic
Composition
Msh3tm1Htr/Msh3tm1Htr
Msh6tm1Htr/Msh6tm1Htr
Genetic
Background
involves: 129P2/OlaHsd * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Msh3tm1Htr mutation (0 available); any Msh3 mutation (61 available)
Msh6tm1Htr mutation (0 available); any Msh6 mutation (52 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice exhibit premature lethality due to tumor development

neoplasm
• 8 of 13 mice develop intestinal tumors
• 3 of 13 mice develop epithelial cancer of the skin
• in 9 of 13 mice

digestive/alimentary system
• 8 of 13 mice develop intestinal tumors

integument
• 3 of 13 mice develop epithelial cancer of the skin





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
11/12/2024
MGI 6.24
The Jackson Laboratory