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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Msh6tm1Htr
targeted mutation 1, Hein te Riele
MGI:2151803
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Msh6tm1Htr/Msh6tm1Htr involves: 129P2/OlaHsd * FVB/N MGI:3851207
cx2
 		Msh3tm1Htr/Msh3tm1Htr
Msh6tm1Htr/Msh6tm1Htr 		involves: 129P2/OlaHsd * FVB/N MGI:3851208


Genotype
MGI:3851207
hm1
Allelic
Composition		 Msh6tm1Htr/Msh6tm1Htr
Genetic
Background		 involves: 129P2/OlaHsd * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Msh6tm1Htr mutation (0 available); any Msh6 mutation (52 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
decreased tumor-free survival time ( J:59561 )
• 75% of mice succumb to tumors within one year

neoplasm
increased gastrointestinal tumor incidence ( J:59561 )
• 2 of 22 mice develop erythroid and intestinal tumors
increased skin tumor incidence ( J:59561 )
• 6 of 22 mice develop epithelial cancer of the skin
increased hemolymphoid system tumor incidence ( J:59561 )
• 2 of 22 mice develop erythroid and intestinal tumors
increased lymphoma incidence ( J:59561 )
• in 12 of 22 mice
increased uterus tumor incidence ( J:59561 )
• 3 of 22 mice develop epithelial cancer of the uterus

digestive/alimentary system
increased gastrointestinal tumor incidence ( J:59561 )
• 2 of 22 mice develop erythroid and intestinal tumors

reproductive system
increased uterus tumor incidence ( J:59561 )
• 3 of 22 mice develop epithelial cancer of the uterus

integument
increased skin tumor incidence ( J:59561 )
• 6 of 22 mice develop epithelial cancer of the skin




Genotype
MGI:3851208
cx2
Allelic
Composition		 Msh3tm1Htr/Msh3tm1Htr
Msh6tm1Htr/Msh6tm1Htr
Genetic
Background		 involves: 129P2/OlaHsd * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Msh3tm1Htr mutation (0 available); any Msh3 mutation (61 available)
Msh6tm1Htr mutation (0 available); any Msh6 mutation (52 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
decreased tumor-free survival time ( J:59561 )
• mice exhibit premature lethality due to tumor development

neoplasm
increased gastrointestinal tumor incidence ( J:59561 )
• 8 of 13 mice develop intestinal tumors
increased skin tumor incidence ( J:59561 )
• 3 of 13 mice develop epithelial cancer of the skin
increased lymphoma incidence ( J:59561 )
• in 9 of 13 mice

digestive/alimentary system
increased gastrointestinal tumor incidence ( J:59561 )
• 8 of 13 mice develop intestinal tumors

integument
increased skin tumor incidence ( J:59561 )
• 3 of 13 mice develop epithelial cancer of the skin




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory