All Phenotypes Hoxd13<tm1Mrc> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Hoxd13^tm1Mrc
targeted mutation 1, Mario R Capecchi
MGI:2151805

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hoxd13^tm1Mrc/Hoxd13^tm1Mrc	involves: 129S7/SvEvBrd	MGI:3513188
ht2	Hoxd13^tm1Mrc/Hoxd13⁺	involves: 129S7/SvEvBrd	MGI:3513189
cx3	Hoxb13^tm1Mrc/Hoxb13^tm1Mrc Hoxd13^tm1Mrc/Hoxd13^tm1Mrc	involves: 129S7/SvEvBrd	MGI:2656751
cx4	Hoxb13^tm2Mrc/Hoxb13^tm2Mrc Hoxd13^tm1Mrc/Hoxd13^tm1Mrc	involves: 129S7/SvEvBrd	MGI:2656752

Allelic Composition	Hoxd13^tm1Mrc/Hoxd13^tm1Mrc
Genetic Background	involves: 129S7/SvEvBrd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxd13^tm1Mrc mutation (0 available); any Hoxd13 mutation (24 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

absent carpal bone ( J:32603 )

• the d4 carpal bone is never properly formed; instead, it yields an extra carpal bone from which grows the postaxial digit VI

brachyphalangia ( J:32603 )

• homozygotes show a reduction or loss of phalange 2 on digits II and V

• phalangeal bones on other digits are also reduced due to abnormal segmentation

polydactyly ( J:32603 )

• homozygotes display the formation of an extra postaxial digit ("VI")

interdigital webbing ( J:32603 )

• interdigital webbing is sometimes observed

short metacarpal bones ( J:32603 )

• homozygotes display severe appendicular skeletal defects, including a significant reduction of metacarpal length

skeleton

absent carpal bone ( J:32603 )

• the d4 carpal bone is never properly formed; instead, it yields an extra carpal bone from which grows the postaxial digit VI

brachyphalangia ( J:32603 )

• homozygotes show a reduction or loss of phalange 2 on digits II and V

• phalangeal bones on other digits are also reduced due to abnormal segmentation

short metacarpal bones ( J:32603 )

• homozygotes display severe appendicular skeletal defects, including a significant reduction of metacarpal length

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:82540 )

N	• ventral prostate appears normal with no reductions in duct tip numbers

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
synpolydactyly		DOID:0060242	OMIM:186000 OMIM:608180 OMIM:610234	J:32603

Allelic Composition	Hoxd13^tm1Mrc/Hoxd13⁺
Genetic Background	involves: 129S7/SvEvBrd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxd13^tm1Mrc mutation (0 available); any Hoxd13 mutation (24 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

abnormal carpal bone morphology ( J:32603 )

• heterozygotes exhibit minor carpal defects, including a slight indentation at the distal border

abnormal digit morphology ( J:32603 )

• heterozygotes display a tiny bony element located postaxially to digit V at a penetrance of 36%

skeleton

abnormal carpal bone morphology ( J:32603 )

• heterozygotes exhibit minor carpal defects, including a slight indentation at the distal border

Allelic Composition	Hoxb13^tm1Mrc/Hoxb13^tm1Mrc Hoxd13^tm1Mrc/Hoxd13^tm1Mrc
Genetic Background	involves: 129S7/SvEvBrd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxb13^tm1Mrc mutation (0 available); any Hoxb13 mutation (9 available)
Hoxd13^tm1Mrc mutation (0 available); any Hoxd13 mutation (24 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

abnormal prostate gland ventral lobe morphology ( J:82540 )

• 50% reduction in the number of duct tips in the ventral prostate

• outgrowth of prostate ducts is reduced

reproductive system

abnormal prostate gland ventral lobe morphology ( J:82540 )

• 50% reduction in the number of duct tips in the ventral prostate

• outgrowth of prostate ducts is reduced

Allelic Composition	Hoxb13^tm2Mrc/Hoxb13^tm2Mrc Hoxd13^tm1Mrc/Hoxd13^tm1Mrc
Genetic Background	involves: 129S7/SvEvBrd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxb13^tm2Mrc mutation (0 available); any Hoxb13 mutation (9 available)
Hoxd13^tm1Mrc mutation (0 available); any Hoxd13 mutation (24 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

abnormal prostate gland ventral lobe morphology ( J:82540 )

• 50% reduction in the number of duct tips in the ventral prostate

• outgrowth of prostate ducts is reduced

reproductive system

abnormal prostate gland ventral lobe morphology ( J:82540 )

• 50% reduction in the number of duct tips in the ventral prostate

• outgrowth of prostate ducts is reduced

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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