Phenotypes associated with this allele

• Allele Symbol: Hoxd8^tm1Jdes
• Allele Name: targeted mutation 1, Jacqueline Deschamps
• Allele ID: MGI:2151815
• Summary: 5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hoxd8^tm1Jdes/Hoxd8^tm1Jdes	involves: 129S2/SvPas * FVB	MGI:3610485
ht2	Hoxd8^tm1Jdes/Hoxd8^+	involves: 129S2/SvPas * FVB	MGI:3610497
cx3	Hoxb8^tm1.1Jdes/? Hoxc8^tm1Phb/Hoxc8^tm1Phb Hoxd8^tm1Jdes/Hoxd8^tm1Jdes	involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * DBA/2 * FVB/N	MGI:3610494
cx4	Hoxb8^tm1.1Jdes/Hoxb8^tm1.1Jdes Hoxd8^tm1Jdes/?	involves: 129P2/OlaHsd * 129S2/SvPas * FVB/N	MGI:3610490
cx5	Hoxc8^tm1Phb/Hoxc8^tm1Phb Hoxd8^tm1Jdes/?	involves: 129S2/SvPas * C57BL/6 * DBA/2 * FVB/N	MGI:3610493

Genotype
MGI:3610485

hm1

• Allelic Composition: Hoxd8^tm1Jdes/Hoxd8^tm1Jdes
• Genetic Background: involves: 129S2/SvPas * FVB

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

asymmetric sternocostal joints ( J:68720 )

• unilateral 8th rib attachment to sternum in 2 out 22 mice

thoracic vertebral transformation ( J:68720 )

• a minority of mice exhibit attachment of an extra rib to the sternum (T8 to T7 transformation)

lumbar vertebral transformation ( J:68720 )

• a minority of mice exhibit development of a rudimentary rib at the first lumbar vertebra (L1 to T13 transformation)

Genotype
MGI:3610497

ht2

• Allelic Composition: Hoxd8^tm1Jdes/Hoxd8⁺
• Genetic Background: involves: 129S2/SvPas * FVB

skeleton

asymmetric sternocostal joints ( J:68720 )

• extra rib attached to one side of sternum in small number of heterozygotes

increased rib number ( J:68720 )

• rudimentary 14th rib in one of 17 heterozygotes examined

Genotype
MGI:3610494

cx3

• Allelic Composition: Hoxb8^tm1.1Jdes/?; Hoxc8^tm1Phb/Hoxc8^tm1Phb; Hoxd8^tm1Jdes/Hoxd8^tm1Jdes
• Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * DBA/2 * FVB/N

skeleton

abnormal thoracic cage morphology ( J:68720 )

• upper ribcage abnormalities are much more prevalent

asymmetric sternocostal joints ( J:68720 )

• bilateral attachment of extra ribs to sternum is less common

increased rib number ( J:68720 )

• presence of L1 ribs less prevalent

thoracic vertebral transformation ( J:68720 )

• T8 to T7 transformation less frequent and not as severe as when Hoxc8^tm1Phb only was mutated

Genotype
MGI:3610490

cx4

• Allelic Composition: Hoxb8^tm1.1Jdes/Hoxb8^tm1.1Jdes; Hoxd8^tm1Jdes/?
• Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * FVB/N

skeleton

abnormal axial skeleton morphology ( J:68720 )

• enhanced upper thoracic abnormalities

Genotype
MGI:3610493

cx5

• Allelic Composition: Hoxc8^tm1Phb/Hoxc8^tm1Phb; Hoxd8^tm1Jdes/?
• Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2 * FVB/N

skeleton

increased rib number ( J:68720 )

• increased presence of fully developed L1 rib

abnormal vertebrae morphology ( J:68720 )

thoracic vertebral transformation ( J:68720 )

• increased penetrance and severity of T8 to T7 transformation

sacral vertebral transformation ( J:68720 )

• S1 to L6 transformation