Analysis Tools
behavior/neurological
| N |
• homozygotes show no differences in ethanol preference relative to wild-type littermates in a two-bottle preference test
• also, homozygotes show normal performance in several behavioral tests, including the Morris water maze assay for learning and memory
|
|
• homozygotes exhibit an olfactory discrimination defect, manifested as reduced ability to avoid the odorant isovaleric acid
|
|
• homozygotes show no obvious defects in motor coordination prior to ethanol injection
• however, mutants are hypersensitive to the effects of ethanol on motor coordination, displaying significantly reduced latencies on the rotarod relative to wild-type
|
homeostasis/metabolism
| N |
• mutants show no differences in blood ethanol concentration or ethanol-induced apoptotic neurodegeneration relative to wild-type
|
reproductive system
| N |
• in contrast to Neurltm1Led mutants, these homozygotes show no apparent deficits in fertility
|
nervous system
| N |
• homozygotes display normal brain size, weight, and morphology relative to wild-type
• mutants show no histological anomalies in the cerebral cortex, cerebellum, striatum, hippocampus, or dentate gyrus
• adult neurogenesis in the dentate gyrus and chain migration of neuronal precursors in the rostral migratory stream appears unaffected
|
