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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ptf1atm1Pkwe
targeted mutation 1, Peter K Wellauer
MGI:2152066
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ptf1atm1Pkwe/Ptf1atm1Pkwe involves: 129P2/OlaHsd MGI:3808167
hm2
 		Ptf1atm1Pkwe/Ptf1atm1Pkwe involves: 129P2/OlaHsd * C57BL/6 MGI:3808165


Genotype
MGI:3808167
hm1
Allelic
Composition		 Ptf1atm1Pkwe/Ptf1atm1Pkwe
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptf1atm1Pkwe mutation (0 available); any Ptf1a mutation (31 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands

nervous system
abnormal cerebellum development ( J:120017 )
• at E16.5, cerebellar primordium is reduced compared to in wild-type mice




Genotype
MGI:3808165
hm2
Allelic
Composition		 Ptf1atm1Pkwe/Ptf1atm1Pkwe
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptf1atm1Pkwe mutation (0 available); any Ptf1a mutation (31 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
neonatal lethality, complete penetrance ( J:51571 )
• though alive 1 day before birth, fewer than expect mice survive the 2 to 3 hours after birth before nursing

endocrine/exocrine glands
decreased pancreatic alpha cell number ( J:51571 )
• at E16, mice have fewer glucagon producing cells than in wild-type mice
• however, the number of glucagon producing cells at E12 is normal
absent pancreas ( J:51571 )
• mice lack a pancreas
• however, all endocrine islet cell types are detected after birth in the mesentery that normally harbors the pancreas until E16

homeostasis/metabolism
hypoglycemia ( J:51571 )
• at birth
cyanosis ( J:51571 )
• at birth

hematopoietic system
abnormal spleen morphology ( J:51571 )
• unlike in wild-type mice, glucagon producing cells and pancreatic endocrine cells are located in the spleen at birth

growth/size/body
decreased body weight ( J:51571 )
• at birth

immune system
abnormal spleen morphology ( J:51571 )
• unlike in wild-type mice, glucagon producing cells and pancreatic endocrine cells are located in the spleen at birth




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory