Phenotypes associated with this allele

• Allele Symbol: Mttp^tm2Sgy
• Allele Name: targeted mutation 2, Steven G Young
• Allele ID: MGI:2152202
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Mttp^tm2Sgy/Mttp^tm2Sgy Tg(Mx1-cre)1Cgn/Tg(Mx1-cre)1Cgn	involves: 129S4/SvJae * C57BL/6 * CBA	MGI:2663704

Genotype
MGI:2663704

cn1

• Allelic Composition: Mttp^tm2Sgy/Mttp^tm2Sgy; Tg(Mx1-cre)1Cgn/Tg(Mx1-cre)1Cgn
• Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

decreased circulating cholesterol level ( J:83459 )

• following induction of cre expression with polyIC, plasma cholesterol levels are reduced by 60%

decreased circulating HDL cholesterol level ( J:83459 )

• following polyIC induction, plasma HDL levels are reduced by 50%

decreased circulating LDL cholesterol level ( J:83459 )

• following polyIC induction, plasma IDL and LDL levels are almost undetectable

decreased circulating VLDL cholesterol level ( J:83459 )

• following polyIC induction, plasma VLDL levels are almost undetectable

decreased circulating triglyceride level ( J:83459 )

• following polyIC induction, plasma triglyceride levels are reduced by 45%

abnormal circulating protein level ( J:83459 )

• following polyIC induction, plasma apoB-100 levels are not detectable

• following polyIC induction, plasma apoB-48 levels are reduced by ~65%

increased liver cholesterol level ( J:83459 )

• following polyIC induction, hepatic cholesterol levels are increased by 65%

increased liver triglyceride level ( J:83459 )

• following polyIC induction, hepatic triglyceride levels are increased 2.5-fold

liver/biliary system

increased liver weight ( J:83459 )

• following polyIC induction, mutant liver weights are increased while body weights remain normal

increased liver cholesterol level ( J:83459 )

• following polyIC induction, hepatic cholesterol levels are increased by 65%

increased liver triglyceride level ( J:83459 )

• following polyIC induction, hepatic triglyceride levels are increased 2.5-fold

abnormal liver physiology ( J:83459 )

• following polyIC induction, apoB-100 is nearly absent in hepatic microsomes while apoB-48 remains unaffected

• following polyIC induction, no changes are observed in the levels of microsomal luminal chaparone proteins or cytosolic heat shock proteins

• following polyIC induction, hepatic secretion of apoB-100 is blocked without causing apoB to accumulate in the hepatic ER

growth/size/body

increased liver weight ( J:83459 )

• following polyIC induction, mutant liver weights are increased while body weights remain normal