All Phenotypes Apoe<tm1Lmh> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Apoe^tm1Lmh
targeted mutation 1, Louis M Havekes
MGI:2152302

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Apoe^tm1Lmh/Apoe^tm1Lmh	involves: 129S7/SvEvBrd * C57BL/6	MGI:2174929
ht2	Apoe^tm1Lmh/Apoe⁺	involves: 129S7/SvEvBrd * C57BL/6	MGI:2174930
cn3	Apoe^tm1Lmh/Apoe^tm1Lmh Ldlr^tm1Her/Ldlr^tm1Her Lrp1^tm2Her/Lrp1^tm2Her Lyz2^tm1(cre)Ifo/Lyz2⁺	involves: 129P2/OlaHsd * 129S7/SvEvBrd	MGI:4943551
cn4	Apoe^tm1Lmh/Apoe^tm1Lmh Ldlr^tm1Her/Ldlr^tm1Her Lrp1^tm2Her/Lrp1^tm2Her Tg(Mx1-cre)29-4Her/0	involves: 129S7/SvEvBrd * C57BL/6J * SJL	MGI:3797226
cx5	Apoe^tm1Lmh/Apoe^tm1Lmh Ldlr^tm1Her/Ldlr^tm1Her	involves: 129S7/SvEvBrd * C57BL/6	MGI:3797227

Allelic Composition	Apoe^tm1Lmh/Apoe^tm1Lmh
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoe^tm1Lmh mutation (0 available); any Apoe mutation (158 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

abnormal lipid homeostasis ( J:22347 )

increased circulating cholesterol level ( J:22347 )

• 2-fold increase in serum cholesterol when fed normal chow

• 3-fold increase in serum cholesterol when fed a hypercholesterolemic diet

• no increase in HDL

increased circulating HDL cholesterol level ( J:22347 )

• 35-fold increase in serum VLDL + LDL when fed a hypercholesterolemic diet

• 160-fold increase in serum VLDL + LDL when fed normal chow

increased circulating VLDL cholesterol level ( J:22347 )

• 35-fold increase in serum VLDL + LDL when fed a hypercholesterolemic diet

• 160-fold increase in serum VLDL + LDL when fed normal chow

xanthoma ( J:24054 )

• when fed a hypercholesterolemic diet for 14 weeks prior to sacrifice, 6 - 7 month old mice showed increased incidence of xanthomatous lesions in multiple tissues, including skin, salivary glands, thyroid glands, muscles, periosteum and upper mediastinum, including the thymus, mesothelium of bladder and kidney, nasal mucosa, choroids plexus, third ventricle, and meniges of the brain and the meniges of spinal cord

Allelic Composition	Apoe^tm1Lmh/Apoe⁺
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoe^tm1Lmh mutation (0 available); any Apoe mutation (158 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

atherosclerotic lesions ( J:22347 )

• atherosclerosis, when fed hypercholesterolemic diet for 14 weeks after weaning

• surface area of lesions was 6 - 30 times larger than sex-matched controls

• lesions in females larger than in males

homeostasis/metabolism

abnormal lipid homeostasis ( J:22347 )

increased circulating cholesterol level ( J:22347 )

• mild hypercholesterolemia when fed a hypercholesterolemic diet with 20-fold increase in serum cholesterol resulting

• no increase in HDL

increased circulating HDL cholesterol level ( J:22347 )

• 35-fold increase in serum VLDL + LDL when fed a hypercholesterolemic diet

increased circulating VLDL cholesterol level ( J:22347 )

• 35-fold increase in serum VLDL + LDL when fed a hypercholesterolemic diet

Allelic Composition	Apoe^tm1Lmh/Apoe^tm1Lmh Ldlr^tm1Her/Ldlr^tm1Her Lrp1^tm2Her/Lrp1^tm2Her Lyz2^tm1(cre)Ifo/Lyz2⁺
Genetic Background	involves: 129P2/OlaHsd * 129S7/SvEvBrd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoe^tm1Lmh mutation (0 available); any Apoe mutation (158 available)
Ldlr^tm1Her mutation (19 available); any Ldlr mutation (81 available)
Lrp1^tm2Her mutation (0 available); any Lrp1 mutation (211 available)
Lyz2^tm1(cre)Ifo mutation (14 available); any Lyz2 mutation (40 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

atherosclerotic lesions ( J:129557 )

• the total macrophage and collagen lesion contents are increased

• the percentage (normalized for lesion size) of collagen in lesions is increased; however, the percentages of macrophages and smooth muscle cells in the lesions are similar

increased susceptibility to atherosclerosis ( J:129557 )

• total atherosclerotic lesion area and the proportion of advanced lesions are significantly increased compared to mutant mice expressing Lrp1

Allelic Composition	Apoe^tm1Lmh/Apoe^tm1Lmh Ldlr^tm1Her/Ldlr^tm1Her Lrp1^tm2Her/Lrp1^tm2Her Tg(Mx1-cre)29-4Her/0
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6J * SJL

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

decreased circulating cholesterol level ( J:90547 )

• following pIpC treatment, plasma cholesterol level is lower compared to mutant mice wild-type for Lrp1

decreased circulating LDL cholesterol level ( J:90547 )

• following pIpC treatment, plasma LDL cholesterol level is lower compared to mutant mice wild-type for Lrp1

decreased circulating VLDL cholesterol level ( J:90547 )

• following pIpC treatment, plasma VLDL cholesterol level is lower compared to mutant mice wild-type for Lrp1

increased circulating cholesterol level ( J:117317 )

increased circulating HDL cholesterol level ( J:117317 )

increased circulating LDL cholesterol level ( J:117317 )

decreased circulating triglyceride level ( J:90547 )

• following pIpC treatment, plasma triglyceride level is lower compared to mutant mice wild-type for Lrp1

increased circulating triglyceride level ( J:117317 )

abnormal circulating protein level ( J:90547 )

• increase in tissue type plasminogen activator levels by 4 weeks after pIpC treatment

abnormal circulating enzyme level ( J:90547 )

• following pIpC treatment, plasma lipoprotein lipase level is higher compared to mutant mice wild-type for Lrp1

• however, no increase in lipoprotein lipase activity is detected

increased circulating factor VIII level ( J:90547 , J:117317 )

• increase in Factor VIII levels by 4 weeks after pIpC treatment (J:90547)

• mice show elevated FVIII (Factor 8) levels (J:117317)

increased circulating von Willebrand factor level ( J:90547 )

• increase in von Willebrand factor levels by 4 weeks after pIpC treatment

cardiovascular system

increased susceptibility to atherosclerosis ( J:90547 )

• increase in lesion size in pIpC treated mice compared to untreated controls

• however, no change in lesion composition is detected

Allelic Composition	Apoe^tm1Lmh/Apoe^tm1Lmh Ldlr^tm1Her/Ldlr^tm1Her
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:117317 )

N	• mice show normal FVIII (Factor 8) levels in plasma

increased circulating cholesterol level ( J:117317 )

increased circulating HDL cholesterol level ( J:117317 )

increased circulating LDL cholesterol level ( J:117317 )

increased circulating triglyceride level ( J:117317 )

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