All Phenotypes Hoxa13<tm1.1Mrc> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hoxa13^tm1.1Mrc/Hoxa13^tm1.1Mrc	involves: 129S1/Sv * 129X1/SvJ	MGI:3846365
hm2	Hoxa13^tm1.1Mrc/Hoxa13^tm1.1Mrc	involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6	MGI:3846356
ht3	Hoxa13^tm1.1Mrc/Hoxa13⁺	involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6	MGI:3846357

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

umbilical artery stenosis ( J:136953 )

• at E11 to E15.5, 1 of 2 umbilical arteries exhibits complete stenosis unlike in wild-type mice

abnormal placental labyrinth vasculature morphology ( J:136953 )

• at E11.5, labyrinth endothelial cells exhibit shortened cell bodies compared to wild-type cells

• at E12.5, labyrinth vascular endothelia cells are rounded unlike wild-type cells

• at E11.5 and E13.5, reduced labyrinth cell body length contributes to loss of vessel wall integrity and extracellular edema between the vessels and underlying syncytiotrophoblasts unlike in wild-type mice

• at E13.5, vascular branching in the placental labyrinth is reduced compared to in wild-type mice

• however, endothelial cell migration and de novo angiogenesis are normal

placental labyrinth hypoplasia ( J:136953 )

• at E13.5, the placental labyrinth is half as thick as in wild-type mice

renal/urinary system

hypospadia ( J:83431 )

abnormal urinary system development ( J:83431 )

• at E11.5, apoptosis in the distal urethral plate epithelium (UPE) is decreased 90% compared to in wild-type mice

• at E12.5, the distal UPE is thicker than in wild-type mice

• proliferation of mesenchyme cells flanking the proximal UPE is decreased compared to in wild-type mice

• at E13.5, the mesenchyme flanking the UPE is vascularized by vessels that are typically 7-fold larger than in wild-type mice

• at E13.5, the UPE protrudes through the distal urethra placing a physical barrier of epithelium at the site where progressing mesenchymal shelves meet and fuse unlike in wild-type mice

• at E15.5, the urethral groove remains exposed, with no fusion of the distal mesenchyme, leaving the placement and formation of the distal meatus undefined unlike in wild-type mice

• however, reduced genital tubercle proliferation can be rescued in vitro by Fgf8 supplementation

• mice fail to exhibit a condensation of medial mesenchyme in the distal section of the penis and disorganized condensation in proximal sections compared with wild-type mice

cardiovascular system

umbilical artery stenosis ( J:136953 )

• at E11 to E15.5, 1 of 2 umbilical arteries exhibits complete stenosis unlike in wild-type mice

abnormal placental labyrinth vasculature morphology ( J:136953 )

• at E11.5, labyrinth endothelial cells exhibit shortened cell bodies compared to wild-type cells

• at E12.5, labyrinth vascular endothelia cells are rounded unlike wild-type cells

• at E13.5, vascular branching in the placental labyrinth is reduced compared to in wild-type mice

• however, endothelial cell migration and de novo angiogenesis are normal

thin ventricular wall ( J:136953 )

• at E14.5, right and left ventricular wall thickness is reduced 43% compared to in wild-type mice

digestive/alimentary system

abnormal rectum morphology ( J:83431 )

• the rectum forms more ventrally and one gestational day earlier than in wild-type mice

homeostasis/metabolism

edema ( J:136953 )

• E11.5 and E13.5, reduced labyrinth cell body length contributes to loss of vessel wall integrity and extracellular edema between the vessels and underlying syncytiotrophoblasts unlike in wild-type mice

Allelic Composition	Hoxa13^tm1.1Mrc/Hoxa13^tm1.1Mrc
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxa13^tm1.1Mrc mutation (0 available); any Hoxa13 mutation (29 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:72301 )

• mice die between E11.5 and E15.5

embryonic lethality during organogenesis, incomplete penetrance ( J:72301 )

• mice die between E11.5 and E15.5

limbs/digits/tail

abnormal limb morphology ( J:72301 )

• authors state that mice exhibit limb defects observed in Hoxa13 knock-out homozygotes

abnormal autopod morphology ( J:72301 )

• cultured autopod mesenchyme cells exhibit reduced adhesion and form 8-fold fewer, smaller, and less robust precartilaginous aggregates compared with wild-type cells

• however, mesenchyme cells will contribute to large precartilaginous aggregates when co-cultured with wild-type cells by anchoring to wild-type cells

• autopod mesenchyme cells fail to segregate from wild-type cells as do cells from heterozygotes

• the autopod mesenchyme is disorganized and the boundaries between the mesoderm and epidermis is poorly defined unlike in wild-type mice

syndactyly ( J:72301 )

• mice exhibit no interdigital separation between any of the fore limb or hind limb digits

• at E13.5, apoptosis between digits II and III is undetectable unlike in wild-type mice

embryo

abnormal umbilical artery morphology ( J:72301 )

• authors state that mice exhibit umbilical vascular defects observed in Hoxa13 knock-out homozygotes

• umbilical arteries exhibit a near complete loss of mesenchymal/endothelial cell layer stratification compared to in heterozygous mice

• the umbilical arteries exhibit disorganized vascular walls compared to in wild-type mice

umbilical artery stenosis ( J:72301 )

• at E10.5, umbilical arteries are narrower than in wild-type mice

• at E13.5, the lumen of umbilical vessels is ablated unlike in wild-type mice