All Phenotypes Grb2<tm1Paw> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Grb2^tm1Paw
targeted mutation 1, Tony Pawson
MGI:2152451

Summary

8 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Grb2^tm1Paw/Grb2^tm1Paw	involves: 129S1/Sv * 129X1/SvJ	MGI:2679601
ht2	Grb2^tm1Paw/Grb2⁺	involves: 129S1/Sv * 129X1/SvJ	MGI:2679600
ht3	Grb2^tm1Paw/Grb2⁺	involves: 129S1/Sv * 129X1/SvJ * BALB/c	MGI:3714659
ht4	Grb2^tm1Paw/Grb2^tm2Paw	involves: 129S1/Sv * 129X1/SvJ	MGI:3719995
cn5	Grb2^tm1Paw/Grb2⁺ Pten^tm2Mak/Pten^tm2Mak Tg(Lck-cre)548Jxm/0	involves: 129P2/OlaHsd * C57BL/6 * CBA	MGI:3717275
cn6	Grb2^tm1Paw/Grb2^tm3.1Paw Tg(Nphs2-cre)1Seq/0	involves: 129S1/Sv * 129X1/SvJ	MGI:5484786
cx7	Grb2^tm1Paw/Grb2⁺ Pten^tm1Mak/Pten⁺	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3717274
cx8	Grb2^tm1Paw/Grb2⁺ Tg(MMTV-PyVT)634Mul/?	involves: 129S1/Sv * 129X1/SvJ * FVB/N	MGI:2679599

Allelic Composition	Grb2^tm1Paw/Grb2^tm1Paw
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grb2^tm1Paw mutation (0 available); any Grb2 mutation (43 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:51424 )

• no homozygous embryos were detectable at E7.5; homozygous embryos were seen at E3.5

embryo

absent inner cell mass proliferation ( J:51424 )

• inner cell mass did not expand

abnormal endoderm development ( J:51424 )

• very few endodermal cells were detectable at E3.5 or in cultured homozygous embryos

cellular

absent inner cell mass proliferation ( J:51424 )

• inner cell mass did not expand

Allelic Composition	Grb2^tm1Paw/Grb2⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grb2^tm1Paw mutation (0 available); any Grb2 mutation (43 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:51424 )

Allelic Composition	Grb2^tm1Paw/Grb2⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * BALB/c

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grb2^tm1Paw mutation (0 available); any Grb2 mutation (43 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased susceptibility to Retroviridae infection ( J:122429 )

• mice exhibit reduced susceptibility to Friend erythroleukemia virus (FV)

• spleen size following FV infection is not as inflamed as in wild-type mice

Allelic Composition	Grb2^tm1Paw/Grb2^tm2Paw
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grb2^tm1Paw mutation (0 available); any Grb2 mutation (43 available)
Grb2^tm2Paw mutation (0 available); any Grb2 mutation (43 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:69138 )

• by E11.5 mice are no longer viable

embryo

absent second pharyngeal arch ( J:69138 )

• at E9 to E10

decreased placental labyrinth size ( J:69138 )

• placental labyrinth is reduced

failure of chorioallantoic fusion ( J:69138 )

• at E9.5 to E10.5, chorioallantoic fusion fails to occur in 32% of mice

cardiovascular system

abnormal heart development ( J:69138 )

hearing/vestibular/ear

abnormal otic vesicle development ( J:69138 )

• large clusters of pycnotic nuclei are present in greater numbers (n=15) in the otic vesicle than in wild-type mice (n=11)

• mesenchyme cells in the otic vesicle undergo more apoptosis than in wild-type mice

nervous system

abnormal facial nerve morphology ( J:69138 )

• cranial nerve VII wanders at the dorsal body edge

abnormal vagus nerve morphology ( J:69138 )

• disorganized

craniofacial

absent second pharyngeal arch ( J:69138 )

• at E9 to E10

Allelic Composition	Grb2^tm1Paw/Grb2⁺ Pten^tm2Mak/Pten^tm2Mak Tg(Lck-cre)548Jxm/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grb2^tm1Paw mutation (0 available); any Grb2 mutation (43 available)
Pten^tm2Mak mutation (4 available); any Pten mutation (88 available)
Tg(Lck-cre)548Jxm mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased T cell derived lymphoma incidence ( J:93530 )

• thymic lymphomas develop with a mean age of onset of 60 days, similar to that seen in T cell-specific Pten homozygotes

endocrine/exocrine glands

increased T cell derived lymphoma incidence ( J:93530 )

• thymic lymphomas develop with a mean age of onset of 60 days, similar to that seen in T cell-specific Pten homozygotes

immune system

increased T cell derived lymphoma incidence ( J:93530 )

• thymic lymphomas develop with a mean age of onset of 60 days, similar to that seen in T cell-specific Pten homozygotes

hematopoietic system

increased T cell derived lymphoma incidence ( J:93530 )

• thymic lymphomas develop with a mean age of onset of 60 days, similar to that seen in T cell-specific Pten homozygotes

Allelic Composition	Grb2^tm1Paw/Grb2^tm3.1Paw Tg(Nphs2-cre)1Seq/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grb2^tm1Paw mutation (0 available); any Grb2 mutation (43 available)
Grb2^tm3.1Paw mutation (1 available); any Grb2 mutation (43 available)
Tg(Nphs2-cre)1Seq mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

renal/urinary system

renal/urinary system phenotype ( J:195444 )

N	• mice exhibit normal podocyte development and kidney function

Allelic Composition	Grb2^tm1Paw/Grb2⁺ Pten^tm1Mak/Pten⁺
Genetic Background	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grb2^tm1Paw mutation (0 available); any Grb2 mutation (43 available)
Pten^tm1Mak mutation (1 available); any Pten mutation (88 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

increased adrenal gland tumor incidence ( J:93530 )

mortality/aging

mortality/aging ( J:93530 )

N	• the embryonic lethality seen in Pten^tm1Mak heterozygotes is completely rescued

neoplasm

increased tumor incidence ( J:93530 )

• develop the same tumor types at the same frequency as Pten^tm1Mak heterozygotes, including neoplastic lesions in the breast, endometrium, prostate, adrenal gland, and lymphoid organs; tumor stage, grade, and metastatic potential are similar to that in Pten^tm1Mak heterozygotes

increased adrenal gland tumor incidence ( J:93530 )

increased lymphoma incidence ( J:93530 )

increased endometrial carcinoma incidence ( J:93530 )

reproductive system

increased endometrial carcinoma incidence ( J:93530 )

Allelic Composition	Grb2^tm1Paw/Grb2⁺ Tg(MMTV-PyVT)634Mul/?
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grb2^tm1Paw mutation (0 available); any Grb2 mutation (43 available)
Tg(MMTV-PyVT)634Mul mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased mammary adenocarcinoma incidence ( J:51424 )

• delayed onset of mammary tumorigenesis compared to wild-type Grb2 mice carrying transgene

integument

increased mammary adenocarcinoma incidence ( J:51424 )

• delayed onset of mammary tumorigenesis compared to wild-type Grb2 mice carrying transgene

endocrine/exocrine glands

increased mammary adenocarcinoma incidence ( J:51424 )

• delayed onset of mammary tumorigenesis compared to wild-type Grb2 mice carrying transgene

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24