Phenotypes associated with this allele

• Allele Symbol: Rax^tm1Mjam
• Allele Name: targeted mutation 1, Milan Jamrich
• Allele ID: MGI:2152531
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rax^tm1Mjam/Rax^tm1Mjam	Not Specified	MGI:2175689

Genotype
MGI:2175689

hm1

• Allelic Composition: Rax^tm1Mjam/Rax^tm1Mjam
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality ( J:97314 )

vision/eye

abnormal eye development ( J:40830 )

• developmental abnormalities visible as early as E9.0 and E10.5

abnormal optic cup morphology ( J:40830 )

• no visible signs of optic cup formation at E10.5

absent optic vesicle ( J:40830 )

• optic vesicle does not form

anophthalmia ( J:40830 , J:97314 , J:111944 )

• no eyes at E13.5 (J:40830)

nervous system

delayed neural tube closure ( J:97314 )

• delayed anterior neural tube closure

decreased midbrain size ( J:40830 )

• reduced size of midbrain

abnormal forebrain morphology ( J:40830 )

• the variability in this phenotype ranges from an absence of a ventral forebrain to the complete absence of a forebrain

abnormal hypothalamus morphology ( J:111944 )

absent forebrain ( J:40830 )

• severely affected embryos have no forebrain

craniofacial

absent optic pit ( J:40830 , J:97314 )

• no optic depressions (sulci) in the neural tube at E9.0 (J:40830)

• optic pit fails to form (J:97314)

abnormal palate morphology ( J:111944 )

• absent

cleft palate ( J:97314 )

• display a spectrum of craniofacial defects including severe ventral and dorsal clefts of the palate

digestive/alimentary system

abnormal palate morphology ( J:111944 )

• absent

cleft palate ( J:97314 )

• display a spectrum of craniofacial defects including severe ventral and dorsal clefts of the palate

embryo

abnormal anterior visceral endoderm cell migration ( J:40830 )

delayed neural tube closure ( J:97314 )

• delayed anterior neural tube closure

cellular

abnormal anterior visceral endoderm cell migration ( J:40830 )

growth/size/body

abnormal palate morphology ( J:111944 )

• absent

cleft palate ( J:97314 )

• display a spectrum of craniofacial defects including severe ventral and dorsal clefts of the palate