Analysis Tools
mortality/aging
|
• 50% of homozygotes fail to thrive and die within 3 days of birth; survival improves to 80% when the larger wild-type and heterozygous littermates are removed
|
growth/size/body
|
• homozygotes are smaller than wild-type or heterozygous littermates
|
|
• newborns are 40-60% smaller than wild-type and heterozygous littermates and during 6-month observation grew but maintained a body weight of 40-60% that of controls; Xrcc5-null mice are proportional dwarfs
|
|
• growth retardation is noted first at E15.5 and size difference is significant at E17.5, increasing to ~40% at birth
|
cellular
|
• after exposure to ionizing radiation, bone marrow cells display less colony formation compared to wild-type
|
|
• cells from null mice show a reduced ability to rejoin DNA double-strand breaks than wild-type
|
immune system
|
• thymus has over 100-fold less cells than wild-type
|
|
• class switching recombination (CSR)-induced Smu internal deletion is impaired
|
|
• spleen contains over 50-fold less cells than wild-type
|
|
• B cell proliferation and apoptosis following LSP or Il-4 treatment was severely impaired even in cells that had undergone several rounds of cell division
|
behavior/neurological
 |
• Xrcc-deficient females are unable to sustain their pups which die in a few days unless nursed by a foster mother
|
hematopoietic system
|
• thymus has over 100-fold less cells than wild-type
|
|
• class switching recombination (CSR)-induced Smu internal deletion is impaired
|
|
• bone marrow reduced lymphoid cellularity compared to wild-type
|
|
• spleen contains over 50-fold less cells than wild-type
|
reproductive system
homeostasis/metabolism
|
• cells from null mice show a reduced ability to rejoin DNA double-strand breaks than wild-type
|
endocrine/exocrine glands
|
• thymus has over 100-fold less cells than wild-type
|
