Phenotypes associated with this allele

• Allele Symbol: Adora2a^tm1Map
• Allele Name: targeted mutation 1, Marc Parmentier
• Allele ID: MGI:2152583
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Adora2a^tm1Map/Adora2a^tm1Map	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3839779
hm2	Adora2a^tm1Map/Adora2a^tm1Map	involves: 129S1/Sv * 129X1/SvJ * CD-1	MGI:3613490

Genotype
MGI:3839779

hm1

• Allelic Composition: Adora2a^tm1Map/Adora2a^tm1Map
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased interleukin-10 secretion ( J:147023 )

• production is suppressed in response to E coli and adenosine

Genotype
MGI:3613490

hm2

• Allelic Composition: Adora2a^tm1Map/Adora2a^tm1Map
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

behavior/neurological

impaired behavioral response to alcohol ( J:97386 )

• homozygotes display no significant differences in acute clearance of ethanol relative to wild-type mice, indicating normal alcohol metabolism

• however, male homozygotes exhibit attenuated ethanol withdrawal-induced seizures, as shown by a significant reduction in handling-induced convulsion scores during acute ethanol withdrawal

decreased exploration in new environment ( J:42276 )

• homozygotes do not display motor/vestibular abnormalities; however, they do exhibit reduced horizontal and vertical exploratory behavior in the open field test

abnormal liquid preference ( J:104141 )

• when given ad libitum access to caffeine (0.3 g/l) and water in a two-bottle paradigm for 12 consecutive days, male homozygotes drink more water and less caffeinated solution than wild-type males, indicating a reduced appetite for caffeine

increased aggression towards male mice ( J:42276 )

• when placed in the same cage, male homozygotes bite each other more frequently than wild-type controls

• resident male homozygotes are much more aggressive towards intruders than wild-type controls; no differences are observed among females

increased anxiety-related response ( J:42276 )

• homozygotes display increased anxiety, spending more time in the closed arms of the elevated plus-maze and in the black compartment of the two-compartment test

abnormal locomotor activation ( J:42276 )

• homozygotes fail to exhibit locomotor stimulation in response to caffeine which normally stimulates exploratory behavior

hypoalgesia ( J:42276 )

• homozygotes display hypoalgesia in response to acute thermal stimuli

increased thermal nociceptive threshold ( J:42276 )

• in the hot-plate test, homozygotes exhibit significantly prolonged latencies for rearing and escape jumping, whereas licking latency remains unaffected

• in the tail-flick test, homozygotes show a 2-fold increase in mean latency relative to wild-type mice

cardiovascular system

abnormal cardiovascular system physiology ( J:42276 )

• in response to A2a-selective agonist CGS 21680, homozygotes fail to exhibit the immediate hypotensive and tachycardic responses observed in wild-type mice

increased heart rate ( J:42276 )

• homozygotes anesthetized by carotid artery catheterization exhibit a significant increase in basal mean heart rate relative to wild-type mice

increased systemic arterial blood pressure ( J:42276 )

• homozygotes anesthetized by carotid artery catheterization exhibit a significant increase in basal mean blood pressure relative to wild-type mice

hematopoietic system

increased platelet aggregation ( J:42276 )

• homozygotes display increased platelet aggregation

homeostasis/metabolism

increased platelet aggregation ( J:42276 )

• homozygotes display increased platelet aggregation

growth/size/body

increased body mass index ( J:42276 )

• at 3 months or older, homozygotes of both sexes exhibit a significantly increased body mass relative to wild-type mice