Phenotypes associated with this allele

• Allele Symbol: Map2^tm1Noh
• Allele Name: targeted mutation 1, Nobutaka Hirokawa
• Allele ID: MGI:2152587
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Map2^tm1Noh/Map2^tm1Noh	involves: C57BL/6	MGI:3575396
cx2	Map1b^tm1Noh/Map1b^tm1Noh Map2^tm1Noh/Map2^tm1Noh	involves: C57BL/6	MGI:3575397

Genotype
MGI:3575396

hm1

• Allelic Composition: Map2^tm1Noh/Map2^tm1Noh
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

decreased body weight ( J:78263 )

• although mice were viable, fertile, and grew normally, body weights were reduced 10-20%

nervous system

abnormal hippocampus morphology ( J:78263 )

• apical dendrites of hippocampal neurons were significantly shorter than normal

abnormal Purkinje cell morphology ( J:78263 )

• microtubule density was 23% less in Purkinje cell dendrites

• cross bridges between microtubules were thinner

Genotype
MGI:3575397

cx2

• Allelic Composition: Map1b^tm1Noh/Map1b^tm1Noh; Map2^tm1Noh/Map2^tm1Noh
• Genetic Background: involves: C57BL/6

mortality/aging

perinatal lethality, complete penetrance ( J:71900 )

• no survival beyond the expected time of birth

• body size was normal however

nervous system

abnormal brain commissure morphology ( J:71900 )

• various fiber tracts are hypoplastic

abnormal corpus callosum morphology ( J:71900 )

• increased size

• does not connect the cerebral hemispheres

decreased anterior commissure size ( J:71900 )

abnormal inferior olivary complex morphology ( J:71900 )

• abnormal folding of the inferior olivary complex

abnormal hippocampus layer morphology ( J:71900 )

• layering in hippocampus and other parts of the brain similar to that in cerebral cortex

abnormal cerebral cortex morphology ( J:71900 )

abnormal stratification in cerebral cortex ( J:71900 )

• molecular layer of cerebral cortex thinner than in wild-type and other layers are unclear or diffuse

abnormal nervous system development ( J:71900 )

• retarded outgrowth of spinal nerves at embryonic day E12

• delayed generation of neurons in more superficial layers of central nervous system

abnormal neuron morphology ( J:71900 )

• neurite lengths in culture shorter than normal

• microtubules of neurons more dispersed with less tendancy to form bundles

• spacing between microtubules is reduced