Analysis Tools
cardiovascular system
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• adult homozygotes exhibit no differences in basal heart rate or basal cardiac function (% fractional shortening) relative to wild-type mice
• no evidence of ventricular hypertrophy or cardiac failure is observed
• isolated hearts and isolated ventricular myocytes display normal baseline diastolic and contractile performance relative to wild-type controls
• in response to isoproterenol infusion, isolated mutant hearts and ventricular myocytes exhibit an increase in myocardial contractility and relaxation similar to that in wild-type controls, suggesting normal sensitivity to beta-adrenergic receptor stimulation
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