Analysis Tools
immune system
|
• increased splenocyte proliferation after stimulation
|
|
• T cells hypersensitive to T cell receptor agonists
|
|
• production is increased
|
|
• Il2 production is reduced
|
|
• Il4 production is reduced about 2 fold per cell
|
|
• TNF-alpha production is increased more than 2-fold
|
|
• abnormal recruitment of leukocytes into inflamed tissue
|
neoplasm
|
• lung cancer metastasis about 50% of controls and never causes cardiac hypertrophy
|
|
• tumor growth much slower (3.4g at 28-30 weeks as opposed to 15g in controls)
|
|
• 50% reduction in the incidence of mammary tumors at 24 weeks of age rather than at 16 weeks as in controls
• male tumor development at 10-13 months of age rather than at 6-9 months
• tumor foci development is normal
|
renal/urinary system
|
• age related reduction in cellularity of the kidney glomerulus
|
behavior/neurological
 |
• deficiencies in nurturing behavior
|
homeostasis/metabolism
|
• mice exhibit lack N-linked beta1,6-branched glycans
• however, mice exhibit normal levels of O-man-linked beta1,6-branched glycans
|
hematopoietic system
|
• increased splenocyte proliferation after stimulation
|
|
• T cells hypersensitive to T cell receptor agonists
|
