Analysis Tools
mortality/aging
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• most homozygotes die within a few days of birth
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nervous system
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• anterior callosal axons fail to cross the midline
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• postmitotic hippocampal cells are generated but fail to differentiate properly and to migrate to correct positions, resulting in abnormal hippocampal morphogenesis
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• although hippocampal neural precursor cells are specified and proliferate, many of them fail to exit the cell cycle
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• at E18.5, the mutant hippocampal ventricular zone is thicker than normal, consistent with an increase in proliferating BrdU-labeled cells in this region
• by E18.5, many BrdU-labeled postmitotic cells migrate out of the ventricular zone but fail to position themselves properly and form the distinctive structures of Ammon's horn and the dentate gyrus
• although postmitotic cells are initially able to acquire certain identities of neurons or glial cells, further neuronal differentiation into the various subclasses of hippocampal neurons (such as pyramidal cells, granular cells, and interneurons) is impaired in the absence of significant apoptosis
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• the choroid plexus of lateral and third ventricles is absent
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• entirely absent at E18.5
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• absence of morphologically distinguishable structures at E18.5
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• absent at E18.5
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• entirely absent at E18.5
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homeostasis/metabolism
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• moribund homozygotes appear cyanotic, suggesting defects in respiratory control centers
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cellular
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• anterior callosal axons fail to cross the midline
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• postmitotic hippocampal cells are generated but fail to differentiate properly and to migrate to correct positions, resulting in abnormal hippocampal morphogenesis
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• although hippocampal neural precursor cells are specified and proliferate, many of them fail to exit the cell cycle
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