Phenotypes associated with this allele

• Allele Symbol: Psmb9^tm1Stl
• Allele Name: targeted mutation 1, Susumu Tonegawa
• Allele ID: MGI:2152729
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Psmb9^tm1Stl/Psmb9^tm1Stl	involves: 129P2/OlaHsd * C57BL/6	MGI:3512777
cx2	Psmb9^tm1Stl/Psmb9^tm1Stl Trp53^tm1Brd/Trp53^tm1Brd	involves: 129P2/OlaHsd * C57BL/6	MGI:3512781

Genotype
MGI:3512777

hm1

• Allelic Composition: Psmb9^tm1Stl/Psmb9^tm1Stl
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased hepatocellular carcinoma incidence ( J:73945 )

• low incidence of spontaneous hepatocellular carcinomas in both sexes

increased leiomyosarcoma incidence ( J:73945 )

• prone to uterine neoplasms

• the number of animals developing overt tumors increases after 6 months of age, mostly leiomyosarcomas

increased lung tumor incidence ( J:73945 )

• low incidence of severe lung tumors seen in both sexes

liver/biliary system

increased hepatocellular carcinoma incidence ( J:73945 )

• low incidence of spontaneous hepatocellular carcinomas in both sexes

hematopoietic system

decreased CD8-positive, alpha-beta T cell number ( J:21549 )

• by 36% in blood

• by 22% in spleen

• by 49% in thymus

abnormal CD8-positive, alpha-beta cytotoxic T cell morphology ( J:21549 )

• 5-6 fold lower levels of cytotoxic T lymphocyte precursors after infection with influenza A virus but not Sendai virus

muscle

increased leiomyosarcoma incidence ( J:73945 )

• prone to uterine neoplasms

• the number of animals developing overt tumors increases after 6 months of age, mostly leiomyosarcomas

immune system

decreased CD8-positive, alpha-beta T cell number ( J:21549 )

• by 36% in blood

• by 22% in spleen

• by 49% in thymus

abnormal CD8-positive, alpha-beta cytotoxic T cell morphology ( J:21549 )

• 5-6 fold lower levels of cytotoxic T lymphocyte precursors after infection with influenza A virus but not Sendai virus

abnormal immune system physiology ( J:21549 )

• splenic lymphoblasts and peritoneal exudates cells are less efficient stimulators of CD8+ T cells

increased susceptibility to Orthomyxoviridae infection ( J:21549 )

• 5-6 fold lower levels of cytotoxic T lymphocyte precursors after infection with influenza A virus but not Sendai virus

respiratory system

increased lung tumor incidence ( J:73945 )

• low incidence of severe lung tumors seen in both sexes

Genotype
MGI:3512781

cx2

• Allelic Composition: Psmb9^tm1Stl/Psmb9^tm1Stl; Trp53^tm1Brd/Trp53^tm1Brd
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

neoplasm

increased tumor incidence ( J:67509 )

• 89% of mice develop tumors

• somewhat decreased survival compared to singly homozygous Trp53^tm1Brd

increased lymphoma incidence ( J:67509 )

• mostly

increased sarcoma incidence ( J:67509 )

• with lesser frequency than lymphomas