Phenotypes associated with this allele

• Allele Symbol: Npr2^cn-2J
• Allele Name: achondroplasia 2 Jackson
• Allele ID: MGI:2152891
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Npr2^cn-2J/Npr2^cn-2J	B6;CBACa A^w-J/A-Npr2^cn-2J/GrsrJ	MGI:4838146
hm2	Npr2^cn-2J/Npr2^cn-2J	B6;CBACa-A^w-J/A-Kcnj6^wv/+	MGI:2183025

Genotype
MGI:4838146

hm1

• Allelic Composition: Npr2^cn-2J/Npr2^cn-2J
• Genetic Background: B6;CBACa A^w-J/A-Npr2^cn-2J/GrsrJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Npr2^cn-2J/Npr2^cn-2J mice have domed heads and shortened long bones and tail compared to controls

reproductive system

abnormal female meiosis ( J:164870 )

♀ • while oocytes in late antral follicles are usually maintained at the germinal vesicle stage with arrested meiosis, 80% of those in homozygotes have already resumed meiosis

cellular

abnormal female meiosis ( J:164870 )

♀ • while oocytes in late antral follicles are usually maintained at the germinal vesicle stage with arrested meiosis, 80% of those in homozygotes have already resumed meiosis

Genotype
MGI:2183025

hm2

• Allelic Composition: Npr2^cn-2J/Npr2^cn-2J
• Genetic Background: B6;CBACa-A^w-J/A-Kcnj6^wv/+

craniofacial

round head ( J:72465 )

• round head

limbs/digits/tail

short femur ( J:72465 )

• short, thick femurs

increased diameter of femur ( J:72465 )

skeleton

skeleton phenotype ( J:72465 )

N • relatively normal vertebrae

short femur ( J:72465 )

• short, thick femurs

increased diameter of femur ( J:72465 )

disorganized long bone epiphyseal plate ( J:72465 )

• disorganized growth plates

splayed ribs ( J:72465 )

• one animal exhibited splayed ribs

growth/size/body

round head ( J:72465 )

• round head

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
achondroplasia		DOID:4480	OMIM:100800	J:72465