All Phenotypes Stil<tm1Mku> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Stil^tm1Mku/Stil^tm1Mku	Not Specified	MGI:3036864
cx2	Ptch1^tm1Zim/Ptch1^tm1Zim Stil^tm1Mku/Stil^tm1Mku	involves: 129 * C57BL/6 * CD-1	MGI:3036865

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:55887 )

• homozygotes die around E10.5

cellular

abnormal apoptosis ( J:55887 )

• extensive apoptosis in the dorsal midline in the neural folds and in somites

embryo

abnormal left-right axis patterning ( J:55887 )

• heart looping is randomized rather than being exclusively to the right

embryonic growth retardation ( J:55887 )

• reduced size and retarded development was apparent by E7.5-E8.5

abnormal neural tube morphology ( J:55887 )

absent floor plate ( J:55887 )

• failure of floor plate development

delayed neural tube closure ( J:55887 )

• delay or failure of the neural tube to close

notochord degeneration ( J:55887 )

nervous system

abnormal neural tube morphology ( J:55887 )

absent floor plate ( J:55887 )

• failure of floor plate development

delayed neural tube closure ( J:55887 )

• delay or failure of the neural tube to close

holoprosencephaly ( J:55887 )

• lack of any midline separation at the anterior end of the cranial neural folds

growth/size/body

embryonic growth retardation ( J:55887 )

• reduced size and retarded development was apparent by E7.5-E8.5

Allelic Composition	Ptch1^tm1Zim/Ptch1^tm1Zim Stil^tm1Mku/Stil^tm1Mku
Genetic Background	involves: 129 * C57BL/6 * CD-1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptch1^tm1Zim mutation (2 available); any Ptch1 mutation (115 available)
Stil^tm1Mku mutation (0 available); any Stil mutation (45 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:72500 )

• homozygotes die around E9.5

• phenotype is identical to that of mice homozygous only for Sil^tm1Mku

cellular

abnormal apoptosis ( J:72500 )

• extensive apoptosis in the dorsal midline in the neural folds and in somites

• phenotype is identical to that of mice homozygous only for Sil^tm1Mku

nervous system

holoprosencephaly ( J:72500 )

• lack of any midline separation at the anterior end of the cranial neural folds

• phenotype is identical to that of mice homozygous only for Sil^tm1Mku

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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